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85 And 119486/79. They are a novel type of antibiotic having both the wide antibacterial spectrum and high safety of penicillin and cephem antibiotics belonging to beta -lactam antibiotics, as well as the potent antibacterial activity and high beta -lactamase stability of carbapenem antibiotics.Sodium-(5R, 6S)-6-[-1-hydroxyethyl]-7-oxo-3- [-2-tetrahydrofuryl]-4-thia-1-azabicyclo [3.2.0] hept-2-ene-2-carboxylate 5/2 hydrate (faropenem sodium, hereinafter referred to as compound 1) is currently used as an oral drug for various infectious diseases and is reported to show potent antibacterial activity against not only methicillin-sensitive Staphylococcus aureus, Streptococcus pyrogenes and Streptococcus pneumoniae but also gram-positive bacteria for which conventional beta -lactam drugs have proved ineffective such as penicillin-resistant pneumococci, oral staphylococci and enterococci, also showing a wide antibacterial spectrum covering gram-negative bacteria such as Haemophilus influenzae and anaerobic bacteria such as the genus Bacteroides, which activity is due to its novel skeleton penem ring (Kagaku Ryoho no Ryoiki The Field of Chemotherapy, Vol.

他们是一种新型的抗生素都具有广泛的抗菌谱和高度的安全青霉素和cephem抗生素,属于β-内酰胺类抗生素,以及作为强大的抗菌活性和高β-内酰胺酶稳定的碳青霉烯类antibiotics.sodium -( 5 R , 6 S )-6 -[ - 1 -羟乙基] - 7 -氧- 3 - [ - 2 - t etrahydrofuryl] - 4 -硫杂- 1 -氮杂双环[ 3 。2.0]庚- 2 -节能- 2 -羧酸5 / 2水合物(法罗培南钠,以下简称为化合物1 )是目前用来作为口服药物,为各种传染病和报道,以显示强大的抗菌活性,不仅对甲氧敏感的金黄色葡萄球菌,链球菌pyrogenes和肺炎链球菌,但也克阳性菌为常规β-内酰胺类药物已证明无效,如青霉素耐药pneumococci ,口腔葡萄球菌和肠球菌,也显示出广泛的抗菌谱,包括革兰阴性菌如流感嗜血杆菌和厌氧菌如属杆菌,这活动是由于其新颖的骨架青霉烯环((化学ryoho没有ryoiki领域的化疗),第13卷,第10号,第74-80 , 1997年)。

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