乙二酸

Eleven novel 2-alkylthio-5-(5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine-5-yl)-1,3,4-oxadiazole derivatives (5) and six novel 2-alkylthio-5-(5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine-5-yl)-1,3,4-thia- diazole derivatives (8) have been designed and synthesized by using 5-amino-3-ethoxycarbonyl-1H-1,2,4-triazole as a starting material.

以5-氨基－1H-1，2，4-三唑－3-羧酸乙酯为起始原料，设计合成了11个新型的2-取代硫醚－5-（5，7-二甲基－1，2，4-三唑并[1，5-a]嘧啶基）-1，3，4-恶二唑类化合物(5)和6个新型的2-取代硫醚－5-（5，7-二甲基－1，2，4-三唑并[1，5-a]嘧啶基）-1，3，4-噻二唑类化合物(8)。

Project Background and Conditions: The company started research new chemical products in 1998. After two years of efforts, a series of pharmaceutical intermediate sulfathiazole leave instructions, including : 3- methyl sulfathiazole leave instructions, 2- sulfathiazole leave instructions ethanoic acid, 2- acetyl sulfathiazole leave instructions, 2-thiofuran amino ethane ,2-thiofuran acetic, 3,4,5- tighter nitrobenzene have been successfully developed. 2-thiofuran amino ethane are the precursors raw materials of series antibiotic analgesic.

二、项目建设背景及条件：1998年公司开始研究开发高新精细化工产品，经过两年的努力，已成功研制出噻吩系列医药中间体，包括：3-甲基噻吩、2-噻吩乙酸、2-乙酰噻吩、2-噻吩乙胺、2-噻吩乙醇、3，4，5-三氯硝基苯等。2-噻吩乙胺系列噻吩产品使用于血小板及血栓有关的心脏血管病及消炎镇痛等如氯吡格雷、兴孢噻吩钠、兴孢西丁、噻吩洛酸等十几种新药的前体原料，是国家政策鼓励发展和有自主知识产权的项目。

The anion UV cured water soluble prepolymer was synthesized with toluene diisocyanate, dihydroxy compound, dihydroxyalkyl carboxylic acid, and polyurethane acrylate. The structure of the prepolymer was characterized by infrared spectroscopy.

采用甲苯二异氰酸酯、聚酯二元醇、二羟甲基丙酸和丙烯酸羟乙酯合成水性阴离子型聚氨酯丙烯酸酯，用傅立叶红外光谱证实了该聚合物的结构。

Two synthetic routes starting from 1,3-dihydroxyacetone and formamidine acetate as well as imidazole-4,5-dicarboxylic acid as starting material were investigated, and the reductive reaction of ethyl imidazole-4-carboxylate was also investigated.

本文对以1，3-二羟基丙酮和醋酸甲脒为原料和以4，5-二羧酸咪唑为原料合成4(5)-羟甲基咪唑的两条工艺进行了研究并优化，同时对4(5)-羧酸咪唑乙酯的还原反应进行了探索性实验。

Dihydroxyacetone; formamidine acetate; imidazole-4,5-dicarboxylic acid; optimizing process; ethyl imidazole-4-carboxylate; reductive reaction; 4(5)-hydroxymethylimidazole

关键字或关键词组： 1，3-二羟基丙酮；醋酸甲脒；4，5-二羧酸咪唑；工艺优化；4(5)-羧酸咪唑乙酯；还原反应；4(5)-羟甲基咪唑

In the presence of catalytic rhodium acetate, ethyl 2-diazo-3-oxo-per fluoroalkanoates, reacted readily with nitriles to give a series of 5-fluoroalkyl substituted 1, 3oxazoles with high regio-selectivity through a metal carbenoid intermediate. The reactions of carbenoids with noncyclic vinyl ethers or cyclic vinyl ethers afforded dihydrofuroates in good to excellent yields. Interestingly, only vinyl C-H insertion compound was obtained concerning of the reaction of carbenoids with 2, 5dimethylfuran due to the steric hindrance of methyl group

醋酸铑分解2-重氮-3-氧代-全氟羧酸乙酯形成的金属卡宾作为1，3-偶极体，可以与一系列芳基或烷基取代的腈反应，高度区域选择性地生成一系列4-乙氧羰基-5-氟烷基取代的噁唑化合物；也可以与富电子的链状和环状的烯基醚反应，以优良的产率得到一系列氟烷基取代的二氢呋喃类化合物；而与2，5-二甲基呋喃的反应，由于甲基的位阻作用，只得到金属卡宾对呋喃3-位烯基碳氢键插入产物。

The resin which was synthesized by the materials of hydroxy silicone oil , 1, 6-hexamethylene diisocyanate, tolylene diisocyanate, pentaerythritol triarylate and 2-hydroxy ethyl acrylate is able to cure rapidly at room temperature by UV.

本实验采用溶液聚合的方法，以端羟基硅油、甲苯二异氰酸酯、六亚甲基二异氰酸酯、丙烯酸—2—羟基乙酯和季戊四醇三丙烯酸酯为原料制备出了新型能够进行快速固化、高效的三官能度封端的光固化反应体系。

A new type of polyaspartic esters secondary amine called PAE-b was prepared from prime amine 4,4'-methylenebis and dialkyl maleates via a Michael Addition Reaction.

通过伯胺4，4'-二氨基环己基甲烷与马来酸二乙酯的Michael加成反应，合成1种新型聚天门冬氨酸酯仲胺。

In this research, liposoluble chlorogenic laurate was synthesized by the acylation with lauroy chloride in the existence of alkali catalyst in non-water phase, and yellowish CGL powders with a yield of 81.24% were obtained under the optimal synthesis conditions determined via single-factor tests and orthogonal experiments, that is, carrying out the acylation at 35℃ for 8h with a n:n: n ratio of 1:1:1.5 and with dimethylformamide as the solvating agent and the thinner.

文中对绿原酸进行了改性，即在碱性催化剂催化的条件下使其与月桂酰氯进行非水相的酯化反应，得到了脂溶性的绿原酸月桂酸酯。经过单因素及正交试验，确定了最佳合成条件为：以N，N-二甲基甲酰胺作为溶解、稀释剂，绿原酸／月桂酰氯／三乙胺的摩尔比为1：1：1.5，温度控制在35℃，反应时间8h。

In this dissertation, preparation of polysubstituted ethene and heterocyclic compounds based on 2-hydroxyalkyl phenyl selenides andα-phenylselenopropionic acid reagents were further investigated as follow: Firstly, O-ethyl-O-vinyl phosphonates were prepared in a one-pot, two-step transformation by Mitsunobu reaction of 2-hydroxyalkyl phenyl selenides with monoethyl esters of phosphonic acid in the presence of diethyl azodicarboxylate and triphenyl phosphine (PPh3) followed by oxidation-eliminatio...

中文摘要：本文主要进一步探索了2-羟基烷基苯基硒醚、α-苯硒基丙酸试剂在制备多取代乙烯和杂环化合物反应中的应用，具体研究内容和结果如下：一、在偶氮二羧酸乙酯和三苯膦(PPh3)存在下，苯基-2-羟基烷基硒醚和O-乙基膦酸单酯发生Mitsunobu反应，无需分离和纯化反应中间体，直接使用30 %的双氧水进行氧化-消除反应，提供了&两步、一锅&合成O-乙基-O-乙烯基膦酸酯的新方法，该方法反应条件温和，操作简便，产物收率良好(76-82 %)。

Lugalbanda was a god and shepherd king of Uruk where he was worshipped for over a thousand years.

Lugalbanda 是神和被崇拜了一千年多 Uruk古埃及喜克索王朝国王。

I am coming just now,' and went on perfuming himself with Hunut, then he came and sat.

我来只是现在，'歼灭战perfuming自己与胡努特，那麼，他来到和SAT 。