乙二酰胺

For the synthesis of NHC precursors, there are also several routes: condensation of glyoxal, amines and paraformaldehyde; alkylation of imidazole or monosubstituted imidazole with alkyl halide; annulation of ortho esters and 1,2-diamines; ring closure of hydrazines or amides with acetic anhydride; reduction of thiones with Na/K in THF.

关于N-杂环卡宾前体的合成途径主要有：乙二醛、伯胺和多聚甲醛的缩合反应；卤代烷与咪唑及其取代咪唑的烷基化反应；原甲酸酯与1，2-二胺的成环反应；肼或酰胺与酸酐的环化反应；用Na/K对环硫脲化合物的还原反应。

hydantoin was synthesized from diethyl malonate comprising condensation with 1, 2-dichloroethane, ammonolysis to diamide, Hoffmann degradation to give 5-cyclopropanespirohydantoin, and ring-opening with 40% hydrobromic acid.

以丙二酸二乙酯为原料，先与1， 2-二氯乙烷缩合生成1， 1-环丙烷二羧酸二乙酯，再经氨解生成1， 1-环丙烷二甲酰胺，然后在次氯酸钙溶液中进行Hoffmann降解成环生成5-环丙螺海因，最后在40%氢溴酸中开环得到5-溴乙基海因。

Lysergic acid diethylamide, LSD, LSD-25, or acid, is a semisynthetic psychedelic drug of the tryptamine family.

麦角酸二乙酰胺， LSD ， LSD-25，或者酸，是半合成吲哚乙胺类致幻剂。

In this paper the antitumour action of 17 phosphoramide nitrogen mustard compounds were studied.

本文研究了17种磷酰胺氮芥类化合物，发現N-双(2-氯乙基)-N'-N-二乙撐基磷酰胺(以下均簡称AT-222)具有較强的抗癌作用。

Amino-6-methoxy Benzothiazole 99%、2-Amino Benzothiazole 99%、Veratraldehyde 99%、Veratric Acid 99%、1,2- Dimethoxy Benzene 99%、6-Nitroveratric Acid 97%、2,5-Dichlorobenzoic Acid 99%、4-Chloro-3-Nitrobenzoic Acid 99%、 3-Nitrobenzole Acid 98%、p-Methoxybenzoie Acid 99%、Anisole 99.5%、p-Methoxyacetophenonc 99%、(2'-Chloroethyl) Benzene 99%、(2'-Bromoethyl) Benzene 99%、N,N-Diethyi-m-Toiuamide 99%、Aminoacetonitrile Hydrochloride 98%、 Alkyl Diphenyl Phosphate Estrel 98%、5-Chloro-2-benzothiazolone 99%、6-bromo-2-naphthol 98%、6-Nitro-Veretric Acid Estrel 97%、4-chloro phenoxyaeetic 99

2-氨基-6-甲氧基苯骈噻唑、2-氨基苯骈噻唑、藜芦醛、藜芦酸、藜芦醚、6-硝基藜芦酸、2，5-二氯苯甲酸、3-硝基-4-氯苯甲酸、3-硝基苯甲酸、对甲氧基苯甲酸、苯甲醚、对甲氧基苯乙酮、β-氯代苯乙烷、β-溴代苯乙烷、N，N-二乙基间甲苯甲酰胺、氨基乙腈盐酸盐、磷酸二苯月桂酯、5-氯-2-苯骈噻唑酮、6-溴-2-萘酚、6-硝基藜芦酸甲酯、4-氯苯氧乙酸

This dissertation is mainly focused on the reactivity of methylenecyclopropanes and comprises six parts. 1 The reactions of methylenecyclopropanes with phenylsulfenyl chloride, phenylselenyl chloride and diphenyl diselenide; 2 The coupling reactions of the ring-opening products derivated from methylenecyclopropanes; 3 The palladium-catalyzed ring-enlargement of mono-aryl group substituted methylenecyclopropanes to cyclobutenes. 4 The gold-catalyzed domino ring-opening and ring-closing hydroamination of methylenecyclopropanes with sulfonamides; 5 The Lewis acid-catalyzed reactions of mono-aryl group substituted methylenecyclopropanes with diethyl ketomalonate in the presence of water; 6 The iodobenzene diacetate mediated novel 1,3-dipolar cycloaddition of methylenecyclopropanes, vinylidenecyclopropanes, and methylenecyclobutane with phthalhydrazine.

本论文主要研究了亚甲基环丙烷类化合物的一些化学反应性能，共由以下六部分组成：1、亚甲基环丙烷类化合物与苯硫氯、苯硒氯及二苯基二硒的反应；2、亚甲基环丙烷类化合物开环产物的偶联反应；3、单芳基取代的亚甲基环丙烷类化合物在钯催化剂作用下的扩环反应；4、金化合物催化磺酰胺对亚甲基环丙烷类化合物的串联开环关环氨氢化反应；5、路易斯酸催化亚甲基环丙烷类化合物与丙酮二羧酸二乙酯在有水存在下的反应；6、醋酸碘苯促进的亚甲基环丙烷类化合物、亚乙烯基环丙烷类化合物及亚甲基环丁烷类化合物与邻苯二甲酰肼的新型1，3-偶极环加成反应。

Bis-imidazoline was prepared from triethylene tetraamine and N,N-dimethylformamide dimethyl acetal at 85℃ for 2 h with toluene as solvent, with a yield of 90.4%. The reaction of bis-imidazoline with 1,2-dibromoethane and potassium carbonate in acetonitrile provided with a monobromide salt yield of 78.7%. Hydrolysis of monobromide salt under aqueous causic solution formed 1,4,7,10-tetraazzcyclododecane in a 74.2% yield.

用甲苯作溶剂，使三乙烯四胺和N，N-二甲基甲酰胺二甲基缩醛在85℃反应2 h，得到中间体双咪唑啉，产率90.4%，在乙腈溶剂中，碳酸钾存在下，双咪唑啉和1，2-二溴乙烷进行扩环反应，得到环状中间体一溴盐，产率78.7%，一溴盐经碱性水解2 h，得到1，4，7，10-四氮杂十二烷，产率74.2%。

Results Eleven compounds were obtained and identified as sarcodonin A, scabronine B, 3β-hydroxy-5α, 8a-epidioxyergosta-6, 22-dien,(22E, 24R)-ergosta-7, 22-diene-3β, 5α, 6β-triol,(22E, 24R)-ergosta-7, 22-diene-3β-ol, benzoic acid, 4-hydroxylben-zaldehyde, 4-monopropanoylbenzenediol, ethy1-β-D-glucopyranoside, thioacetic anhydride,(2S, 2'R, 3S, 4R)-2-(2-hydroxyoctadecanoylamino) docosane-1, 3, 4-triol.

结果共分离鉴定了11个化合物，分别是：sarcodonin A、scabronine B、3β羟－5α，5α-过氧麦角甾－6，22-二烯－3β-醇、(22E，24R)-麦角甾－7，22-二烯－3β，5α，6β三醇、(22E，24R)-麦角甾－7，22-二烯－3β-醇、苯甲酸、对羟基苯甲醛、对羟基苯甲酸乙酯、乙基－β-D-吡喃葡萄糖苷、硫代乙酸酐、（25，2'R，3S，4R）-2-（2-羟基－十八碳酰胺）二十二碳烷－l，3，4-三醇。

Could keep above 95% in the fixed beds. In order to achieve high stereo-selectivity with yeast, ethyl acetoacetate was used as the model substrate,and a novel approach was proposed to selectively inhibit R-enzymes in yeast before reaction.

以乙酰乙酸乙酯为模型底物，以丙烯酸、乙醚、二甲基亚砜、丙烯酰胺、正己烷等有机溶剂选择性地抑制酵母中R型酶，提高反应立体选择性。

In this research, liposoluble chlorogenic laurate was synthesized by the acylation with lauroy chloride in the existence of alkali catalyst in non-water phase, and yellowish CGL powders with a yield of 81.24% were obtained under the optimal synthesis conditions determined via single-factor tests and orthogonal experiments, that is, carrying out the acylation at 35℃ for 8h with a n:n: n ratio of 1:1:1.5 and with dimethylformamide as the solvating agent and the thinner.

文中对绿原酸进行了改性，即在碱性催化剂催化的条件下使其与月桂酰氯进行非水相的酯化反应，得到了脂溶性的绿原酸月桂酸酯。经过单因素及正交试验，确定了最佳合成条件为：以N，N-二甲基甲酰胺作为溶解、稀释剂，绿原酸／月桂酰氯／三乙胺的摩尔比为1：1：1.5，温度控制在35℃，反应时间8h。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。