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乌拉坦

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In contrast, the Smad7 transgenic animals had an increased incidence of lung carcinogenesis when subjected to urethane treatment.

同时,在Smad7转基因小鼠模型中,乌拉坦诱导的肺癌发生率明显高于对照组,提示在呼吸道上皮细胞中阻断TGF-b信号通路能够促进肺癌的发生发展。

AIM To observe the dynamic changes of cardiac autonomic nervous function in rabbits under different depth of urethane anesthesia.

目的观察乌拉坦不同麻醉深度下家兔心脏自主神经功能的变化特征。

The effects of intracerebralventricular injection of nitric oxide donor and nitric oxide synthase inhibitor on the spontaneous discharge of magnocellular neurons of paraventricular nucleus of hypothalamus were investigated in urethane anaesthetized adult SD rats by using microelectrode extracellularly recording method.

乌拉坦麻醉的成年SD大鼠上,用玻璃微电极细胞外记录的方法,观察了脑室内注射一氧化氮供体及一氧化氮合酶抑制剂对室旁核大细胞自发电活动的作用。

METHODS: The rats in the two groups were anaesthetized by intraperitoneal injection of 10 g/L urethane (1 g/kg) and the chest was opened to insert a tube into the ascending aorta for perfusion with 200 mL of the mixture containing glutaric dialdehyde and paraformaldehyde for fixation.

两组大鼠给予质量浓度为10 g/L的乌拉坦1 g/kg腹腔内注射,麻醉后开胸,升主动脉插管,戊二醛与多聚甲醛混合固定液200 mL灌流固定,取嗅球,振荡切片,锇酸后固定,平板包埋,光镜下选取嗅球各层,制备超薄切片,透射电镜下对比观察。

Measure microcirculation both in brain pial and parenchyma with Laser Doppler Flowmetry.

实验时将大鼠以10%乌拉坦腹腔注射麻醉(0.01mL/g体质量),头顶部矢状缝两侧钻孔后分别置入激光多普勒微循环电极,测定软脑膜及脑实质血流。

The induction effects of SO 2 inhalation on micronuclei formation in the polychromatophilic erythroblasts of mouse bone marrow and protection effect of Seabuckthorn seed oil were studied in vivo.

结果表明:(1)短期与长期 SO2 吸入均可引起小鼠骨髓 PCE细胞微核率和微核细胞率显著升高,且有明确的剂量-效应关系;(2 )随着吸入的 SO2 浓度的增高,不仅单微核细胞率,而且双微核细胞率均显著升高;(3) SO2对阳性致突变剂乌拉坦诱发微核的作用有显著抑制效应;(4 )沙棘油对 SO2 诱发 PCE微核的效应有防护作用。

Study Design: All tests were conducted on polyurethane foam sternal models.

研究设计:所有的试验均在聚乌拉坦泡沫胶胸骨模型上进行。

Methods The rabbits were anesthetized and removed the heart. The left atrium was isolated and fixed on the atrial perfusion system and paced by electrical stimulation. Atrial pulse pressure was measured via a pressure transducer connected to the intra-atrial catheter and recorded on a physiograph.

方法将大耳白兔耳缘静脉注射乌拉坦(20 mg/kg)麻醉后,立即开胸取出心脏,剥离左心房迅速固定在心房灌流装置上,并给予适宜的电刺激使心房搏动,利用生理记录仪持续记录相关药液影响下的心房搏动压的变化,并读取每搏输出量。

N=6.1.Sham operated group: which were administrated with 10% glucose injection(2ml/kg) abdomently. One hour later, w ire narcotized with Urethane, then,one side femoral vein was separated.

假手术组:术前1h腹腔注射10%GS注射液2ml/kg,然后用乌拉坦(1.0g/kg)麻醉后分离一侧股静脉,由股静脉注入NS0.1ml/kg。

Sixty-two artificially respired rabbits were anesthetized with urethae.Intranuclear microinjection was adopted.Microinjection of TRH into Lc-Sc induced a marked increase in respiratory frequency and significant elevation of blood pressure.The above mentioned effects of TRH into Lc-Sc on RF could be blocked by preinjection of α2 or β receptor antagonist into RVLM respectively.

实验选用62只行乌拉坦静脉麻醉和人工呼吸的家兔,采用脑内核团微量注射的方法,将TRH微量注入蓝斑复合核,使呼吸频率明显增快,平均动脉血压升高;在延髓头端腹外侧区分别预注射α2或β受体阻断剂,使TRH在蓝斑复合核的呼吸增频效应明显减弱,其升压效应可被延髓头端腹外侧区分别预注射α或β受体阻断剂拮抗。

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