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Objective: The purpose of our studies are gaining a better insight into the effect of genistein on mesangial cell"s phenotype change and ECM expression plus degradation under DN circumstances.We add genistein with different concentrations in high glucose cultured rat mesangial cells;feed DM rats with the single concentration genistein for different days;to explore the expression of SMemb,the mark of mesangial cell"s hypertrophy phenotype change;to examine the synthesis of Fn as well as the change of the balance between MMP-2 and TIMP-l;to comprehend its effect on renal pathological changes of DM rats and some related factors;trying toexplore the possible mechanisms.Through these studies,we will have some information about the experimental value of genistein in DN field.

目的:为了研究金雀异黄素对DN环境下大鼠MC肥大表型转换标志物SMemb和ECM分泌及降解的影响,我们拟在细胞水平以不同浓度的金雀异黄素作用于高糖培养下大鼠MC,在动物水平以同一浓度的金雀异黄素作用于DM大鼠不同时间,观察细胞表型转换标志物SMemb、ECM主要成分Fn、ECM降解酶系统基质金属蛋白酶—2(MMP-2)/基质金属蛋白酶抑制剂—1(TIMP-1)表达的变化,同时观察金雀异黄素对DM大鼠肾脏病理及影响肾脏病进展的糖脂代谢紊乱的影响,并进一步探讨金雀异黄素发挥作用的可能机制;为明确金雀异黄素在DN治疗中的地位及意义提供实验依据。

It showed that main constituents are linalool, geraniol, farnesol , safrole, citral, t-anethole , decanal and lauric aldehyde respectively and with high cont.

从它们的利用部位花、果、叶和根中,可提取芳香油,主要成分分别为芳樟醇、香叶醇、金合欢醇、黄樟素、柠檬醛、茴香醚及癸醛、十二碳醛等,含量相当高,为重要调香原料,有的作药用,颇具发展种植和开发利用价值。

These rocks were originally formed by molten residues, and contain the main components of quartz and feldspar.

这些岩石最初形成的熔融残留物,并且包含的主要成分是石英和长石。

Relative content of-Anethole was increased accompanying increased duration, while Fenchone was decreased.

为 0.92 ml·(100g)-1。精油主要成分反式茴香脑的相对含量随着蒸馏时间的延长而不断上升,小茴香酮的相对含量都随着蒸馏时间的延长而不断下降。

To investigate the effect of high temperature treatment on essential oil in fennel ,fruit of fennel was held at three temperature(40 ℃,60 ℃,80 ℃) and 25 ℃ for 7 days,then extracted essential oil and identified components by GC/MS.

结果表明:随着温度的升高,精油含量与主要成分的相对含量均呈先升高再降低的趋势,其中精油含量依次为0.93、3.04和3.17和1.51ml。

Fennel seeds of different areas were differ in contend and major component relative contents of essential oil.

我国不同来源茴香在精油含量及主要成分的相对含量上均存在一定的差异。

Acid electrode main component of skin medicine acidic oxides such as silica, titanium dioxide, ferric oxide and so on.

酸性焊条药皮的主要成分为酸性氧化物,如二氧化硅、二氧化钛、三氧化二铁等。

ConclusionThe main components of volatile oil of resin and basilar leaves in the Ferula lehmanni Boiss are tuaiacol, terpenoids. Multisulfides have not been determined.

大果阿魏树脂、基生叶的挥发油主要成分是:愈创木醇、萜类化合物,未检出多硫化物。

Methane is inflammable and explosion hazard gas as the basis of mash gas, firedamp and rock gas .

甲烷作为瓦斯、天然气、沼气等的主要成分,是易燃易爆气体。

A rectangle cake of rice is formed, and then a slice of raw fish or other topping

吃天妇罗时要蘸着一种特制的油,这种油的主要成分是酱油。

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According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm~150rpm时取得最大值,此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世,形体几无变化。

When I was in school, the rabbi explained everythingin the Bible two different ways.

当我上学的时候,老师解释《圣经》用两种不同的方法。