主要

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗(来源：A44B8787C论文网www.abclunwen.com)功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

This paper is composed of six chapters. In the Introduction, the author outlines reasons for topic selection, scope of anil approach to research, major findings and key themes of each chapter. Chapter Ⅰ.

本文共有六章，结构安排与主要内容如下：导论，阐述了本文选题的缘由、研究对象与研究方法，阐述了本文的研究思路，概括了各章的主要内容和基本观点。

The transcripts of XSox1 are detected in the animal pole at cleavage and blastrula stages and mainly in the central nervous system and the developing eye at neurula stages.

原位杂交结果显示，在早期卵裂阶段和囊胚期，Sox1基因主要在动物极表达；从神经板期开始，Sox1基因主要在中枢神经系统和眼原基中表达。

Glycogen: A polysaccharide,(C6H 10O 5) n, that is the main form of carbohydrate storage in animals and occurs primarily in the liver and muscle tissue. It is readily converted to glucose as needed by the body to satisfy its energy needs. Also called animal starch

肝糖：糖原，(C6H 10O 5) n，构成碳水化合物贮存在动物体组织中的主要形式，主要存在于肝和肌肉，可备来转化成葡萄糖以补充身体所需能量也作 animal starch

Mitochondria are not only the major source of energy metabolism, but also the source of superoxide anion production in cell.

线粒体不仅是细胞内能量的主要来源，而且是细胞内自由基的主要产生地。

Data obtained by thin-sections analysis, cathodoluminescence emission analysis and SEM/EDX show that carbonate cements seem to be the uppermost cements composed of ferroan sparry calcite and ankerite and are distributed mostly in the depth interval of 100 m below the unconformity, with their contents increasing with the depth.

通过薄片观察、阴极发光、扫描电镜/能谱分析，认为碳酸盐胶结物是研究区砂岩最主要的胶结物成分，其主要类型为方解石和铁白云石，垂向上含量随深度增加而增加，多集中分布在白垩系和侏罗系之间的不整合面之下约100 m的范围之内。

However, the grape is easy to suffer from some plant diseases in the production process, such as frosty mildew、white rot、anthrax、anthracnose and so on.

葡萄是河北省主要的农副产品之一，河北涿鹿为长城葡萄酒酿酒公司提供了主要的原材料。

Based on the three dimensional surface data of the face and skull, methods of geometric analysis on them are presented through these parameters with their numerical calculating methods under the landmarks of the anthropologist and anthropometrist are proposed,which is the foundation of the statistical model that will be used in the field; 4Geometric analysis methods that based on the approximation coefficients of spherical harmonic functions are proposed.

以三维面皮和颅骨数据为基础，分别给出了基于公安法医学标志点和人体测量学标志点的几何分析主要途径和方法，确定了几何分析的主要参量，并给出了相关的计算方法，为建立颅面统计模型奠定基础； 4基于球面调和函数的颅面形态学的几何分析方法。

The decrease in farming land and the increase in forestry and grass land resulted from adjustment of agricultural structure and the implementation of Three North Shelter Belt and other anti-desertification projects , while the degradation of pasture resulted from unreasonable human being activities and pasture tenure.

耕地面积减少和林草地面积增加主要是由于农业生产结构的调整和"三北"防护林工程及其他治沙工程的实施，而草原持续退化主要是不合理的人为活动和草原使用"责、权、利"不明确等因素共同造成的。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。