主动脉的

The accentuation of vascular sensitivity to α2-AR agonist may be one of the mechanisms of abdominal aorta hyperreactivity.

对α2-AR之激动剂敏感性上调可能是高位SCT大鼠腹主动脉高反应性的原因，而α1-AR在血管高反应性中不起作用。

Objective:To explore the diagnosis and treatment of aneurysm of sinus of Valsalva.

目的：探讨主动脉窦瘤的诊断及治疗方法。

Rat AAA model was made by perfusion PPE elastase through the abdominal aorta, and the specimen was obtained on postoperativeday 3, 7, 14, 28, respectively. Specific elastic fiber staining was used to observe the disruption of elastic fiber in aortic wall. Immunohistochemistry staining of CD68 was applied to observe the microphage infiltration. The in tisu hybridization and western blot of MCP-1 and MMP-2 were used to study the expression of mRNA and protein. Thus we can analyze the facilitated function of MCP-1 gene to the microphage adherence and infiltration on the earlier AAA.

采用经腹主动脉腔内导管灌注的方法制成大鼠AAA模型，分别于术后3天、1周、2周、3周、4周获取各组大鼠腹主动脉标本，行弹力纤维特殊染色观察动脉壁弹力纤维的破坏情况；行CD68免疫组织化学染色观察动脉壁中巨噬细胞的浸润；行MCP-1及MMP-2的原位分子杂交、Western蛋白质印迹观察二者的mRNA表达和蛋白表达；分析MCP-1基因促进巨噬细胞的黏附、浸润在早期AAA发病中的作用。

After administration of L-N〓-nitro-Arginine, a specific antagonist of NOS, it was found that the basal and stimulated NO release of blood vessels (aorta, internal carotid, renal and mensenteric artery) was decreased further. The increase of coronary blood flow stimulated by Ach was also reduced further, while the platelet aggregation degree and erythrocyte aggregation index increased significantly. Pathological examination indicated that aortic endothelium was destroyed, the blood vessels in cerebral, cardiac and renal tissues were hypertrophied further and some were almost occluded. The above fin dings resulted in SHR feeded with L-NNA having high incidence of stroke rate and high degree of renal cirrhosis when compared to control SHR. The infarct and hemorrhagic focuci in cerebral tissues, infarct focuci in cardiac tissues, atrophy and hyalinedegeneration of renal glomeruli and degeneration even necrosis of renal tubuli in renal tissues were al so found. The increase ratio of brain and heart to body weight and decrease ratio of kidney to body wei ght further demonstrated that the cerebral, cardiac and renal injuries were aggravated.

在上述结果的基础上进一步给予SHR NOS特异性拮抗剂左旋亚硝基精氨酸后，血管(胸主、颈内、肾及肠系膜动脉)NO基础释放及激动剂刺激释放进一步减少，Ach刺激冠脉流量的增加和胸主动脉内膜NOS活性也进一步减少，血小板聚集程度及红细胞聚集指数显著上升，病理切片显示胸主动脉内皮细胞破坏明显，脑心肾组织内的血管进一步增厚甚至几乎阻塞，导致饲L-NNA的SHR缺血性及出血性脑卒中发生率显著高于对照SHR，脑体重比显著升高；心肌内出现明显的缺血梗塞疤痕灶，心体重比显著升高；肾小球明显萎缩、玻璃样变性，肾小管也变性甚至坏死，使肾硬化程度显著增加呈颗粒性固缩肾，肾体重比也显著减少。

Results AE from CM had vasodilating effect on the contracti on of mesentery blood capillary in guinea pigs and the contraction of rat thoracic aortic ring induced by l0μmol/L phenylephrine, even under the condition of pre-treating with glibenclamide (1μmol/L) or propranolol (3μmol/L). When the endothelium of the rat thoracic aortic ring was removed, AE from CM had not vasodilating effect hut constrictive effect. AE from CM could also increase the contents of NO, NOS and cNOS in the aortic tissue and had no obvious effect on the NO content in plasma and iNOS in aortic tissue of rats.

结果 桑白皮丙酮提取物有抑制去甲肾上腺素收缩豚鼠肠系膜微血管的作用，抑制苯肾上腺素(10μmol/L)收缩离体大鼠胸主动脉环的作用，预加优降糖或普蔡洛尔(3μmol／L)后仍然有松弛作用；大鼠胸主动脉环去内皮后药物无松弛作用，反而起收缩作用；显著升高血管的NO和NOS、cNOS含量，对大鼠血浆的NO和血管iNOS的含量影响不大。

Sometimes individuals with Marfan syndrome who have had repair of the upper portion of the aorta have enlargement of other parts of their aortas.

有时候个人与马凡氏综合征是那些已修复的上层部分的主动脉有扩大的其他部分，他们的主动脉。

RESULTS Expression rate of MHCI antigen of cultured smooth muscle cells and fibroblast was（88.7±4.3）%,（84.8±2.0）%respectively;and that of the revived smooth muscle cells and fibroblasts of aortic homografts after cryopreservation was（89.4±3.5）%,（81.9±2.7）%respectively.

结果 正常培养的大鼠主动脉平滑肌细和成纤维细胞MHCⅠ类抗原表达的阳性率分别为（88.7±4.3）%和（84.8±2.0）%；液氮低温保存的大鼠主动脉平滑肌和成纤维细胞在复苏后MHCⅠ类抗原表达的阳性率分别为（89.4±3.5）%和（81.9±2.7）%。

RESULTS Expression rate of MHCI antigen of cult ured smooth muscle cells and fibroblast was (88.7±4.3)%,(84.8±2.0)%respectively; and th at of the revived smooth muscle cells and fibroblasts of aortic homografts after cryoprese rvation was (89.4±3.5)%,(81.9±2.7)%respectively.

结果正 常培养的大鼠主动脉平滑肌细和成纤维细胞MHC Ⅰ类抗原表达的阳性率分别为(88.7±4.3)％和(84.8±2.0)％；液氮低温保存的大鼠主动脉平滑肌和成纤维细胞在复苏后MHC Ⅰ类抗原表达的阳性率分别为(89.4±3.5)％和(81.9±2.7)％。

Congenital aortic stenosis occurs due to improper development of the aortic valve in the first 8 weeks of fetal growth.

主动脉狭窄的发生是由于在胎儿生长发育的前8周里主动脉瓣的不正常的发育。

"Because of the possible risks associated with aortic valve replacement in the elderly, almost 60 percent of patients with symptoms related to aortic stenosis are not referred to surgery," says lead researcher James S.

&因为主动脉瓣膜置换在高龄患者中可能存在的风险的，几乎有60%的显示主动脉狭窄的征兆患者不能进行外科手术，&这项研究的负责人James S。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。