主动脉瓣闭锁不全

These women, ages 61, 72 and 74 years, receiving long-term pergolide therapy for Parkinson's disease or restless legs syndrome, had valvular abnormalities strikingly similar to those induced by fenfluramine, ergot derivatives, or carcinoid. All three had severe, unexplained tricuspid regurgitation; two had predominantly right-sided congestive heart failure; and two had moderate aortic and mitral valve regurgitation. Histology revealed surface fibroproliferative lesions with preserved underlying valve architecture. Carcinoid was excluded, and none of the patients had taken anorectic drugs or ergots other than pergolide.

这3位妇女年龄分别为61、72及74岁，都长期服用pergolide来治疗帕金森氏症或睡眠脚动症，而且也都有不明原因的严重三尖瓣闭锁不全，就像因fenfluramine、麦角衍生物，或类癌肿瘤所引起的瓣膜异常情形一样；其中2位主要有右心衰竭，2位有中度的主动脉及二尖瓣的闭锁不全，组织学检查显现表面有纤维增生性的损伤，但瓣膜的结构仍然还在；类癌是被排除在外的，而且这3位妇女除了pergolide之外，都不曾服用过厌食剂或麦角类药物。

Valvular heart disease, usually aortic and mitral insufficiency, can complicate a variety of systemic diseases.

瓣膜性心脏病，以主动脉瓣及二尖瓣闭锁不全为最常见，可使各种全身性疾病变得复杂。

Valvular heart disease , usually aortic and mitral insufficiency, can complicate a variety of systemic disease s

瓣膜性心脏病，以主动脉瓣及二尖瓣闭锁不全为最常见，可使各种全身性疾病变得复杂。

The arterial pulse pressure in aortic insufficiency is widened.

主动脉瓣闭锁不全时脉搏压变宽。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。