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METHODS: The vasodilatory effects of pinacidil and nifedipine were studied on rat aorta rings precontracted with 10 μmol·L -1 norepinephrine or 80 mmol·L -1 potassium chloride respectively.

大鼠离体主动脉环以10μmol·L-1去甲肾上腺素或80mmol·L-1KCl预收缩后,分别以不同浓度的吡那地尔和硝苯地平对抗。

Results: Nitrendipine could relax concentration-dependently the arterial rings of the rat U-Ⅱ precontracted arteries -log

结果:尼群地平可浓度依赖性舒张大鼠U-Ⅱ预收缩的肺主动脉环[-log(EC50)=5.86±0.30, Emax=(73.73±15.40)%,以30nmol/L U-Ⅱ的收缩幅度为100%]。

Dilatiry of AS on rat thoracic aorta strips precontracted by noradremaline(1μmol/L)and KCl(30mmol/L)were proved.

结果 AS松弛去甲肾上腺素(1μmol/L)和氯化钾(30mmol/L)预收缩的大鼠胸主动脉条,其EC 50 分别(35.9±3.1)和(36.7±3.1)μmol/L。

Our results indicated that (1)SO_2 derivatives could dose-dependently relax the isolated aorta rings with or without endothelium precontracted by NE, no difference was found for the rings with and without endothelium;(2)Levels of cAMP and 6-Keto(PGI_2) in isolated aortic rings were increased by SO_2 derivatives in a dose-dependent way, which were independent of endothelium;(3)SO_2 derivatives decreased cGMP levels in the rings, but not significantly; The decrease of cGMP levels was also independent of endothelium;(4)No changes of TXB_2 in rings with or without endothelium were observed;(5)Whether presence or absence of endothelium, cAMP/cGMP and 6-Keto/TXB_2 ratios were increased significantly.

结果:①SO_2衍生物对去甲肾上腺素预收缩的内皮完整和去除内皮的大鼠胸主动脉血管环均呈浓度依赖性舒张作用,且其张力变化在内皮完整与去内皮的血管环之间无显著性差异;②SO_2衍生物可引起血管组织中cAMP、6-Keto(即PGI_2)含量剂量依赖性增加,其增加程度与内皮无关;③SO_2衍生物对血管环cGMP含量呈降低趋势但在统计学上无显著意义,且对去除内皮血管无显著影响;④SO_2衍生物对去内皮或内皮完整血管环的TXB_2含量均无明显影响;⑤无论是否去除内皮,SO_2衍生物均可引起cAMP/cGMP和6-Keto/TXB_2比值显著升高。

Acclimatization 1.73±1.82** 0.61±0.06 0.98** P<0.01 vs normoxic rats.After the aorta preparations were precontracted with NE at the concentration of 0.62 μmol/L, a ccumulative vasodilative effects of ACh were tested.

与常氧对照组相比,急性低氧和间断低氧习服后,大鼠主动脉对ACh各浓度(10- 9~10-5 mol/L)引起的舒张反应显著减弱(P<0.01),其最大舒张分别为常氧对照组的87.3%和79.7%,其EC50值分别为1.34和1.73 μmol/L,分别为常氧对照组EC50值0.20 μmol/L的6.7和8.6倍(表2)。

AS is a disease process akin to atherosclerosis in which calcification and tissue remodelling play a crucial role.

主动脉瓣狭窄的病变过程与动脉粥样硬化相类似,钙化和组织重建都是关键的病变机制。

Imple, rapid, and effective method of producing aortocaval shunts in the rat.

D大鼠腹主动脉-下腔静脉分流术致肺动脉高压模型的建立。

Methods. Six 1-month-old cales underwent left-sided thoracotomies, exposing the anterior thoracic spine and aorta.

6头1个月大的小牛行左侧开胸,显露胸椎前方和主动脉

However,aortie fatty streaks were strongly related to ante一mortem levels of both total and low一density liPopro一tein eholesterol(:=0.67,p.0001 for eaeh assoei一ation),independently of raee,sex,and age,andwere inversely eorrel...

主动脉脂肪条纹与死前总胆固醇及低密度脂蛋白胆固醇水平密切相关r=0.67,P(0.000一,二者同,与种族、性别、年龄无关,而与高密度脂蛋白胆固醇对低密度及极低密度脂蛋白胆固醇之比成负相关r二一。

In the same scanning plane, a cross-section of the ascending aorta is seen.

在同一平面上也可看到升主动脉的横切面。

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