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Endothelin, recently isolated from culture supernatant of porcine aortic endothelial cells, is a novel potent vasoconstrictive substance.

内皮素是最近从猪主动脉内皮细胞培养上清液分离出的一种由21个氨基酸组成的新的强缩血管物质。

METHODS: Differences of the vasodilating action of Ipt in big artery and small artery were studied using isolated rat tai l artery helical strips and aortic rings, and the effects of Ipt on potassium cu rrents in smooth muscle cells derived from rat tail artery were observed by usin g patch clamp technique.

采用大鼠尾动脉螺旋状血管条和主动脉离体血管环两种组织,对比观察盐酸埃他卡林对大、小动脉扩张作用的药理学特性,并且利用膜片钳技术观察盐酸埃他卡林对大鼠尾动脉平滑肌细胞钾电流的影响。

L-1 (10-7mol . L-1) noradrenaline induced contraction of rat aortic strip was taken as criterion. Compound I5 was shown to be a potent potassium channel activator. Compound II8 exhibited calcium antagonistic activity and showed potent vasodilating activity.

引起的大鼠主动脉条收缩有较好的抑制作用,其中化合物 I5的钾离子开放活性与尼可地尔相当,化合物 II8显示有钙离子通道拮抗活性,并有较强的扩血管活性。

Isolation and characterization of vasoformative endothelial cells from the rat aorta.

瞬间热处理大鼠主动脉内皮细胞分离培养法。解剖学杂志,2004,27(5):

Aim: To study the effects of angiotensin receptor antaganist-valsartan on vascular hypertrophy、vasomotion function and aorta vascular smooth muscle cell EGF precursor mRNA expression in spontaneously hypertensive rats.

目的:本文探讨血管紧张素受体拮抗剂-缬沙坦对自发性高血压大鼠血管结构、功能以及主动脉血管平滑肌表皮生长因子前体 mRNA表达的影响。

This is a woundless, nonenzymatic method of obtaining highly purified primary endothelial cells of the rat aorta, especially practical for isolation and culture of small vascular endothelial cells.

此方法无损伤、不需要酶消化,能比较容易的获得高纯度大鼠原代主动脉内皮细胞,适用于细小血管内皮细胞的分离与培养。

Methods A total of 36 patients with advanced renal cancer were definitely diagnosed by IVP, US, CT or MRI examination. A 5F Yashiro catheter was introduced into the femoral artery with Seldinger's technique under local anesthesia, abdominal aortagraphy and renal arteriography in both sides of kidneys were performed routinely to display the blood supplying arteries of tumor, thereafter, renal embolization was performed under superselective catherization for chemotherapeutic embolizing. Then the clinical effect was observed, the amount of blood loss and the operation time were recorded. All these results were compared with that of randomly selected 17 patients before surgical operation with advanced renal cancer admitted during the recent 3 years but without embolization.

36例中晚期肾癌患者,均经临床检查、静脉肾盂造影、B超、CT或MRI检查而确诊;采用Seldinger's技术,局部麻醉下经一侧股动脉穿刺插管,引入5F Yashiro导管,常规行腹主动脉及双肾动脉造影,以显示肿瘤的供血动脉,再将导管超选择插管或尽可能接近肿瘤病灶,进行化疗栓塞,观察其临床改善情况,计算术中失血量及手术时间,并与随机抽取我院近3年所做的17例术前未行肿瘤供血动脉栓塞的肾癌患者进行对照。

By setting up a rabbit HHcy and AS model induced by homomethionin diet,to observe the influence of Guanxinkang on the levelof blood fat, tHcy in blood plasma and the expression of MCP-1,VCAM-1, Bcl-2,MMP-2in endotheliocyte of aorta in model rabbit with HHcy. 30 masculine Zelanian albinorabbit have been selected for the experiment.

通过高蛋氨酸饮食建立兔高同型半胱氨酸血症和动脉粥样硬化模型,观察中药冠心康复方对HHcy模型兔血脂、血浆Hcy、胸主动脉内皮细胞中MCP-1、VCAM-1、Bcl-2、MMP-2表达水平的影响。

A large blood volume could be obtained by abdominal aorta approach, which leads to less haemolysis and no hurt to organs, no gas embolism or haemostasis caused by inappropriate operation.

主动脉采血法适用于取血量大的实验,不易溶血,不损伤器官,不会出现因操作不当造成的气栓与瘀血,有利于病理组织学检查。

In addition, the team found that ERK5-SUMOylation was increased in the aortas of diabetic mice.

同时,研究组发现ERK5-SUMO结合物在糖尿病大鼠的主动脉中含量增加。

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