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The spinal cord ischemia-reperfusion model was made by clamping the infrarenal aortic in rabbits.

采用肾下腹主动脉阻断法,建立脊髓缺血再灌注损伤模型。

METHODS Spinal cord ischemia was induced by occluding infrarenal abdominal aorta.

采用腹主动脉肾下段夹闭法建立兔脊髓缺血模型。

BACKGROUND: Long-term data describing small abdominal aortic aneurysms and increasing infrarenal aortic diameters and their relationship to future surgical repair, total mortality, and incident cardiovascular disease events, particularly among women, are sparse.

背景:描述较小腹主动脉瘤的长期资料和逐渐增加的肾下主动脉直径,以及它们与将来实行外科手术修补、总死亡率、易发心血管事件之间的关系,尤其是在女性中的资料更是稀少。

Results The pathological characters with mild, moderate and severe spinal cord ischemia/reperfusion injury can be simulated by declamping after 30 min, 45 min and 60 min infrarenal aortic cross-clamping.

结果:阻断腹主动脉血流30、45,60min后开放表现出轻、中、重不同程度缺血再灌注损伤脊髓的病理变化特点。

BACKGROUND: Long-term data describing small abdominal aortic aneurysms and increasing infrarenal aortic diameters and their relationship to future surgical repair, total mortality, and incident cardiovascular disease events, particularly among women, are sparse.

摘要翻译:背景:描述较小腹主动脉瘤的长期资料和逐渐增加的肾下主动脉直径,以及它们与将来实行外科手术修补、总死亡率、易发心血管事件之间的关系,尤其是在女性中的资料更是稀少。

METHODS:Hind limbs ischemia was made by clamping infrarenal aorta with a microvascular clip and lung injury was made by following reperfusion. Lung tissue was obtained from the animals subjected to sham operation, 4 h ischemia without reperfusion and 4 h, 8 h, 16 h, 24 h, 48 h reperfusion following 4 h ischemia. The levels of HO-1 mRNA and protein were measured at different times by Northern blot and Western blot.

采用夹闭大鼠腹主动脉下段造成双下肢缺血和再灌注性肺损伤模型,分别采集假手术组,缺血4 h组及缺血4 h再灌注4、8、16、24、48 h组肺组织标本,以Northern印迹、Western印迹及免疫组化分析,观察HO-1表达的变化。

Methods:Twenty-three patients with CAOD awaiting bypass operation were observed as research group.Thirty-one patients undergoing elective open repair of an infrarenal abdominal aortic aneurysm were observed as control group. Clamping and declamping arterial for anastomoses were served as ischemia reperfusion injury. LDH, CK, MB as indicators of skeletal injury before operation and first 3 days after operation were detected.

以接受旁路手术治疗的23例慢性下肢动脉闭塞患者为试验组,以接受腹主动脉原位置换的31例腹主动脉瘤患者为对照组,以术中阻断及开放血管为急性IRI因素,以乳酸脱氢酶、肌酸激酶、肌红蛋白为检测指标,研究两组骨骼肌对急性IRI的反应。

METHODS 24 patients diagnosed coarctation of aorta or interrupted aortic arch with congenital heart defects, aged 6 to 197 days average (78±58)days,weighed 2.3 to 5.6 kg average (4.0±0.8)kg,were randomly divided into DHCA group(n=15) and SACP group(n=9).Continuous SACP was established via the innominate artery cannulation after reaching target temperature, the flow rate was kept 15-30 ml/.

主动脉缩窄或主动脉弓中断合并心内畸形患儿24例,其中男20例,女4例,年龄6~197 (78±58)d,体重2.3~5.6(4.0±0.8)kg,随机分为DHCA组(15例)和SACP组(9例),后者在降至目标温度后经无名动脉顺行插管行持续性SACP,灌注流量15~30 ml/。

RESULTSThe branches of aortic arch are the left and right innominate artery in pate of mini-pig.

结果小型猪主动脉弓部向头颈部分支为左、右无名动脉;双侧颈内动脉均来自右无名动脉,故右无名动脉对脑底供血十分重要;双侧有沿脊柱向尾侧走行的折返动脉;胸主动脉背侧由胸6至胸14平面共发出8条肋间动脉,为胸腰脊髓的主要供血动脉;无腰大动脉。

To maintain the hemodynamics, the inotropic agents and/or intraaortic balloon pump were used.

使用正性肌力药物和/或主动脉内球囊反搏维持循环。

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