中间体

Methods 4-Hydroxybenzonitrile (2) as the starting material was transformed to 4-hydroxy-thiobenzamide (3) via thioformylation. And ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate (4), which was synthesized via cyclization from 3, was treated with hexamethylenetetramine to generate the intermediate ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate (5). The target compound febuxostat (1) was obtained from 5 by etherification, cyanidation, hydrolysis.

以羟基苯腈为原料，经硫代甲酰化得到对羟基硫代苯甲酰胺(3)，3经环合得到2-（4-羟基苯基）－4-甲基－噻唑－5-羧酸乙酯(4)，4与乌洛托品反应，得到中间体2-（3-甲酰基－4-羟基苯基）－4-甲基－噻唑－5-羧酸乙酯(5)，之后再经醚化、氰化、水解得到目标产物(1)。

The company,Humate International Limited,is one of professional manufacturers and suppliers of Humate series,chemical materials and intermediates in China.

天津休美特国际贸易有限公司是中国腐植酸系列产品，草酸，硫氢化钠，硫化钠等化工原料和中间体的专业生产供应商之一。

Pyrocatechol and hydroquinone, as important raw material intermediates in fine chemical industries, are used in many fields.

邻、对苯二酚是重要的精细化工原料中间体，用途非常广泛，市场的需求量很大。

That is because of their high activity,whichoften acted as an intermediate or initiator in many chemical reactions.

这主要是因为这些物种具有高活性，时常是许多化学反应的中间体或引发剂。

Use solvent and reagent is innocuity safety.

所用的试剂安全无毒，得到的产品的纯度高、品质优，符合GMP、药品注册管理办法和中国药典2005版的要求，可作为食品添加剂中间体和单体药原料使用。

Operation covering all types of organic chemical raw materials, inorganic chemical raw materials and pharmaceutical intermediates.

经营范围涉及各类有机化工原料、无机化工原料及医药中间体等。

This should include all package inserts and examples of the immediate container labels.

这应包括所有的包装说明书以及中间体容器标签的样品。

Corresponding reactants, products, intermediates, and interconversion transition states are located on the reaction potential energy profiles.

得到了详细标注反应物、产物、中间体和过渡态的势能面示意图。

The invention pertains to the technical field of medial intermediate compound synthesis, in particular to method to prepare 4-acetylenyl phenylformic acid.

本发明属于药物中间体合成技术领域，具体涉及一种4-乙炔基苯甲酸的制备方法。

The drug, including a total of three intermediate, higher technology and technology products.

该药物共包括三个中间体，产品工艺科技含量较高。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。