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Anencephaly, the single most common open neural tube defect, is characterized by the absence of the cerebral hemispheres and the lack of bony calarium aboe the orbits Fig.

无脑畸形,最常见的单一的开放性神经管缺损,其特点是无大脑半球且没有眼眶以上的骨性颅盖(图10-37A-B和图10-37C)。胎儿有正常的中脑和后颅窝,但大脑半球未正常发育。

But the latent period for reaching the platform above the water in Morris Water Maze of the Mn-exposed group was not different from that of control group. There was a significant increase in the areas,glial fibrillary acid proteinimmunoreactivity and the average proportional densities of GFAP-positive elements in nucleus caudate and accumbens in the high Mn-exposed group, and a significant reduction in the tyrosine hydroxylase immunoreactivity and average proportional densities of TH-positive elements in substantia nigra,ventral tegmentum area of midbrain and nucleus caudate in the high Mn-exposed group.

2高剂量染锰组尾状核和伏隔核的面积、胶质细胞纤维酸蛋白免疫反应强度及反应阳性产物的平均相对密度均较对照组显著升高;(3)高剂量组仔鼠黑质、中脑腹侧被盖区和尾状核的酷氨酸氢氧化酶免疫反应强度及其反应阳性产物的平均相对密度均比对照组明显下降。

There was a significant increase in the areas,glial fibrillary acid proteinimmunoreactivity and the average proportional densities of GFAP-positive elements in nucleus caudate and accumbens in the high Mn-exposed group, and a significant reduction in the tyrosine hydroxylase immunoreactivity and average proportional densities of TH-positive elements in substantia nigra,ventral tegmentum area of midbrain and nucleus caudate in the high Mn-exposed group.

2高剂量染锰组尾状核和伏隔核的面积、胶质细胞纤维酸蛋白免疫反应强度及反应阳性产物的平均相对密度均较对照组显著升高;(3)高剂量组仔鼠黑质、中脑腹侧被盖区和尾状核的酷氨酸氢氧化酶免疫反应强度及其反应阳性产物的平均相对密度均比对照组明显下降。

Under the light microscope, the earliest TH-positivc cells at embryonic day 13 are localized at the ventral part of rostral midbrain. Later appearing TH-positive cells join the earlier ones dorsally and caudally.

最早的TH阳性细胞首先于胚胎13天在中脑吻端的腹侧出现;随后出现的TH阳性细胞从尾端和背侧逐渐加入早先出现的TH细胞。

To observe the influence of tumor necrosis factora on differentiation of rat mesencephalic neural stem cells,the numbers of neurons,astrocytes and oligodendrocytes generated from NSCs were analyzed after differentiation for 3 days by using i m munocytoche mistry technique.

为观察肿瘤坏死因子对神经干细胞分化的影响,本研究应用体外扩增的新生大鼠中脑NSCs,使用免疫组织化学技术,观察了肿瘤坏死因子一。对NSC、分化及其后代细胞的影响。

Neurogenesis and development of the central nervous system in the embryo stage of swimming crabs, Portunus trituberculatus, were studied by the histological method.

应用组织学方法研究三疣梭子蟹胚胎期中枢神经系统的发生和发育,光学显微镜下镜检切片,在第二期卵内无节幼体阶段开始观察到脑;第二期卵内状幼体阶段,前脑由视神经层、侧原脑和中央原脑组成,与位于食道两侧的中脑和后脑形成完整的脑。

MR findings in addition to the primary ascular insult may include prominence of the cortical sulci and perimesencephalic cistern but some patients demonstrate absence of such generalized sulcal prominence.

除了原发的血管病变以外,MRI所见包括脑沟和中脑池的增大,但是一些病人没有脑池或者脑沟的扩大。

Microinjection of glucocorticoid or mineralocorticoid (40 or 10 ng/0.1 ul/site) into the rVLM bilaterally caused an increase in BP, HR and the pressor response induced by the dPAG stimulation in the normotensive rat, respectively. Dose-dependence of both drugs was observed on the above effects in three directions. Nevertheless, there was no effect of both drugs on the tachycardiac response induced by the dPAG stimulation.

二、分别微量注射糖、盐皮质激素(40或10ng/0.1μl/site)至双侧rVLM,可引起正常血压大鼠的BP升高,HR加快,以及电刺激中脑中央周围灰质背侧区诱发的防御性升压反应增强,并均呈现出剂量-效应依赖性关系,而对电刺激dPAG诱发的加快心率反应无明显改变作用。

The distribution pattern of mGnRH in the brain during regressed stage was similar to that during recrudescing stage.

退化期和再发育期蛙脑中mGnRH的分布规律基本相同:即端脑-嗅球、视前-交叉区、下丘脑-正中隆起的mGnRH含量彼此相近;而上丘脑-中脑及小脑-延脑的mGnRH含量为0。

At 24 h, Ang1 was expressed mainly in the lens, optic cup, mesencephalon, ventral part of hindbrain, and myotomes in the somites, while zfTie2 was mainly expressed in intersomitic vessels including dorsal aorta and axial veins, and sprouting vessels from the dorsal aorta in the trunk. VEGF was expressed mainly in the lens, optic cup, mesencephalon and myotomes in the somites, while zfFlk1 was mainly expressed in intersomitic vessels including dorsal aorta and axial veins, and sprouting vessels from the dorsal aorta in the trunk.

结果从受精卵胚胎发育第12小时可见血管内皮细胞生长因子和血管发生素1及其相应受体flk1和Tie2的表达;在受精卵胚胎发育的第16小时,血管内皮细胞生长因子和血管发生素1主要在头部和尾部胚芽表达;第24小时在眼球、视窝、中脑、后脑的腹前侧和肌节中表达,Tie2和Flk1主要在肌间背部动脉血管、躯干新生血管芽和轴向静脉中表达。

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