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BACKGROUND: A series of studies have demonstrated that ventral mesencephalic dopamine precursors may differentiate into considerable dopaminergic neurons available for cell transplantation for Parkinson's disease.

摘要背景:一系列研究表明,腹侧中脑多巴胺能前体细胞可在体外经人工诱导分化为大量多巴胺能神经元,有望用于移植治疗帕金森病,但是其分子特征尚不明了。

CONCLUSION摘要: EGB761 can protect embryonic rat mesencephalic DAergic neurons against MPP+induced apoptotic death in a dosedependent manner.

结论摘要:EGB761对MPP+诱导的胚胎大鼠中脑原代培养细胞损伤具有保护功能,且此功能有随剂量的增大而增加的趋向。

Objective To investigate the degeneration of dopaminergic neurons induced by MPP+ in mouse mesencephalic dissociated culture and establish the cell model for parkinson'[KG-*3]s disease research in vitro.

目的: 探讨1-甲基-4-苯基-四氢吡啶离子对小鼠胚胎中脑原代培养多巴胺能神经元的毒性作用及其机制。

Parkinson's disease is one of aging diseases, of which progressive degeneration of the mesencephalic dopaminergic neuron is its pathologic hallmark.

帕金森氏病(Parkinson's disease,PD)是以中脑多巴胺神经元进行性退变为主要病理特征的老年性疾病。

Methods: 1. A model of Transwell has been developed for the co-culture nearly pure microglia cells and dopaminergic neurons.

研究方法 1、用原代培养的方法建立小胶质细胞与中脑多巴胺能神经元体外培养的Transwell细胞模型。

To observe the influence of tumor necrosis factora on differentiation of rat mesencephalic neural stem cells,the numbers of neurons,astrocytes and oligodendrocytes generated from NSCs were analyzed after differentiation for 3 days by using i m munocytoche mistry technique.

为观察肿瘤坏死因子对神经干细胞分化的影响,本研究应用体外扩增的新生大鼠中脑NSCs,使用免疫组织化学技术,观察了肿瘤坏死因子一。对NSC、分化及其后代细胞的影响。

Given that one has such a sensitive belief in P, then it must be the case that the brain-in-a-vat skeptical world is, modally speaking, far out, for if it weren't, then this would affect the sensitivity of the subject's beliefs in ordinary propositions like P.

假定某人有这样一个语境敏感的信念P,那么,必然的是瓮中脑世界太远,因为如果不是太远那么这会影响诸如P这样的日常命题之相信的敏感性。

MRI showed brain atrophy in 11 cases,delayed myelinization in 8 cases,periventricular leukomalacia in 6 cases,abnomal signals of the basal ganglia in 5 cases,brain malaria in 5 cases,cortical infarction in 3 cases and congenital deformation in 4 cases,no abnormal finding in 3 cases.

中脑萎缩11例,脑白质髓鞘发育延迟8例,脑室周围白质软化灶6例,基底节异常信号5例,脑软化灶5例,皮层梗死病灶3例,先天畸形4例。3例患者MRI检未见明确异常。

Results: Of the 22 cases, the draining veins, which were observed through MR brain surface anatomy scanning, were highly coincidence with the findings in the operation. The myodynamia of the one case whose myodynamia was grade 0 preoperation was grade IV one month after operation, the one case whose myodynamia was grade II preoperation was grade IV two weeks after operation, the one case whose myodynamia was grade III preoperation was grade IV three months after operation, and the patient recovered normal eight months later, the two cases whose myodynamia was grade IV total recovery after 2 months .

结果:22例患者的术前磁共振脑表面成像中脑表面回流静脉与术中所见高度一致。1例肌力0级患者术1月恢复至 IV 级,1例 II 级患者术后2周恢复至 IV 级,1例 III 级患者术3月恢复至 IV 级,随访8月患者对侧肢体肌力恢复正常,2例 IV 级患者术后2月完全恢复。

N The CSF may be normal in some cases of neurosyphilis, so that lumbar puncture does not ,with certainty, exclude the diagnosis.

n 在一些神经梅毒中脑脊液可能是正常,脑脊液检查不能排除神经梅毒。

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