中枢周的

Anorectic effects of GLP-1 are most apparent when the peptide is administered directly into the central nervous system, but suppression of food intake has also been noted in some cases with peripheral administration.

研究显示，GLP抑制食欲的作用在GLP-1被注射到中枢神经系统的时候是最明显的，但是外周摄取GLP-1也能起到抑制食欲效果。

These results suggest that the activate spleen-energy method can achieve appetitive purpose by not only affecting the gastrointestinal tract function in periphery, but also regulating the process of ingestion in brain. The basic research about ingestion indicate: one hand, after food enters the gastro-intestinal tract, the endocrine cell of the intestinal tract is activated and secrete many kinds of brains intestines peptide, the level of the brain intestines peptide in blood as the periphery signal spreads to the central nervous system regions that control digest and feeding behavior. On the other hand, it has been shown that dorsal parabranchial neurons, containing CCK-8S, extend fibers to the VMH and are involved in the inhibition of feeding .

关于摄食控制的基础研究表明，一方面食物进入胃肠道后，激活肠道的内分泌细胞，分泌多种脑肠肽如CCK-8S，这些脑肠肽在血中的水平作为外周信号可通过"肠—脑轴"传入中枢神经系统介导消化和摄食行为的部位，影响摄食中枢神经元的活动调节动物的摄食行为；另一方面中枢神经元可合成释放内源性的神经肽直接作用于摄食中枢神经元调节摄食，如中枢鳃旁体神经元的神经纤维就可延伸到达VMH，并且合成释放内源性的CCK-8S。

ChAc is an Ach's biological synthesizing enzyme and special mark of every cholinergic neuron.

ChAc是乙酰胆碱的生物合成酶，也是胆碱能神经元的特异标志酶，存在于所有胆碱能神经元，ChAc免疫反应活性被用于鉴别中枢和外周的胆碱能神经元。

Extensive sprouting of sensory afferents and hyperalgesia induced by conditional expression of nerve growth factor in the adult spinal cord.

传统观点认为，蓝斑核是介导吗啡戒断反应的主要部位，但大量研究表明，作为联系外周神经和高位中枢纽带的脊髓在吗啡戒断反应中发挥重要作用[18-20]。

GDNF has been reported to exhibit trophic actions on various neurons of central nervous system and peripheral nervous system .

GDNF对中枢及外周的多种神经元有神经营养作用，与目前已知的神经营养因子相比，GDNF对受到损伤的多巴胺能神经元和运动神经元的促存活作用最为显著。

And they systematically studied the effect of the activate spleen-energy law on digestive and absorptive function, it is confirmed that the activate spleen-energy law have significant regulation effect on the action and secretion of gastrointestinal tract. Recently, we established the juvenile rat model with anorexia by imitating the major cause of children and found that the CCK-8S concentration in hypothalamus and periphery blood of the anorexy model was obviously increased .We also found the appestat that the spontaneous discharge frequency of LHA neurons was decreased and the spontaneous discharge frequency of VMH neurons was increased.

近几年，我们采用病因模拟法成功建立了幼龄大鼠厌食模型并发现该模型下丘脑和外周CCK-8S水平显著增高，食欲中枢——下丘脑外侧区神经元自发放电频率减低和下丘脑腹内侧区神经元自发放电频率增加，临床治疗小儿厌食有可靠疗效的运脾复方不仅可调节外周血中与摄食有关的肽类激素水平，如降低CCK-8S水平，而且能调节下丘脑食欲中枢神经元的自发放电频率。

The results were compared among 4 groups. Results:①OCB positive rate was 37% in MS patients, which was lower than other reports, 24% in central nervous system infectious diseases group,5% in central nervous system non-infectious diseases group and 0 in peripheral nervous system diseases group,respectively.②OCB positive rate in conventional MS was 56%, which was higher than that in neuromyelitis optica.

结果①多发性硬化组OCB阳性率为37%，中枢神经系统感染组为24%，中枢神经系统非感染性疾病组为5%，外周神经系统疾病组为0；多发性硬化组的OCB阳性率比其他各组高，但低于国外报道的阳性率；②多发性硬化患者中传统型多发性硬化组OCB阳性率为56%，高于视神经脊髓炎组的11%。

These results suggest that the activate spleen-energy method can achieve appetitive purpose by not only affecting the gastrointestinal tract function in periphery, but also regulating the process of ingestion in brain. The basic research about ingestion indicate: one hand, after food enters the gastro-intestinal tract, the endocrine cell of the intestinal tract is activated and secrete many kinds of brains intestines peptide, the level of the brain intestines peptide in blood as the periphery signal spreads to the central nervous system regions that control digest and feeding behavior. On the other hand, it has been shown that dorsal parabranchial neurons, containing CCK-8S, extend fibers to the VMH and are involved in the inhibition of feeding .

关于摄食控制的基础研究表明，一方面食物进入胃肠道后，激活肠道的内分泌细胞，分泌多种脑肠肽如CCK-8S，这些脑肠肽在血中的水平作为外周信号可通过&肠—脑轴&传入中枢神经系统介导消化和摄食行为的部位，影响摄食中枢神经元的活动调节动物的摄食行为；另一方面中枢神经元可合成释放内源性的神经肽直接作用于摄食中枢神经元调节摄食，如中枢鳃旁体神经元的神经纤维就可延伸到达VMH，并且合成释放内源性的CCK-8S。

Objective : To measure the differences of total T cell percentages of peripheral blood, peripheral immune organs and central immune organs of maters of interspecific, intraspecific embryo implantation and pseudopregnant mice at corresponding time, and to analyze the effects of these differences on interspecific embryo implantation.

目的：研究种间胚胎植入期母体外周血、外周免疫器官、中枢免疫器官中总T细胞的百分比变化，并探讨这种变化对种间胚胎植入的影响。

To sdudy the clinical and radiological features and the therapeutic efficacy of cavernous angiomas in central nervous system.

中枢神经系统海绵状血管瘤鲍伟民周良辅姜观富摘要目的：分析总结中枢神经系统海绵状血管瘤的临床和放射学特点及治疗效果。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐