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The 20S catalytic core of the 26S proteasome has the shape of a barrel made of four rings which are composed of seven differentαsubunitsα_1-α_7 at two outer rings and seven differentβsubunitsβ_1-β_7 at two inner rings at which the catalytic sites locate. Three of theβsubunits contain proteolyses sites, which are sequestered in the hollow interior of the 20S particle. Substrates enter the 20S through a narrow channel formed by theβsubunits, whose N-termini, depending on their conformation, can either obstruct or allow substrate entry and thus function as a gate. This entry channel is narrow and only permits passage of unfolded, linearized polypeptides.

哺乳动物26S蛋白酶体是由一个20S催化颗粒(catalytic particle,CP)和两个19S调节颗粒(regulatory particle,RP)组成的ATP(adenosine-triphosphate,ATP)依赖性蛋白水解酶复合体。20S CP是26S蛋白酶体的催化核心,它是由4个圆环堆叠形成的桶状复合物,其中两侧外环每个环是由α_1-α_7亚基组成,两个内环每个环是由β_1-β_7亚基组成,4个环的中央形成一个狭窄的内腔。2个β内环形成了20S CP的催化中心空腔,其内壁为催化活性位点所在地;外侧α环中心的孔道是底物到达催化中心空腔的通道,一般被α亚基上的N末端所封闭,阻止胞内非目的靶蛋白进入20S CP内被降解破坏。

Since the multiple scattering should be considered, the scattering problem of many-cylinders is more complicated than single cylinder. By using scattering matrix method to solve the scattering problem of many-cylinders, first we have to express the incident fieldand scattered field by special function(for example, Bessel function and Hankel function)under cylindrical coordinate, then use the addition theorem of special function to get a linear system of equations to relate the incident field coefficients and scattered field coefficients. The incident and scattered field coefficients for every cylinder can be solved from the linear equations by matching electromagnetic boundary condition pointwisely.

单颗圆柱散射体的散射场解析解很早就被解出,而多个圆柱阵列的散射场问题因为涉及到入射光在圆柱与圆柱间的多重散射,故散射行为较单颗圆柱的散射复杂,因此圆柱阵列的多重散射问题需要利用加法定理来处理;散射矩阵法的主要精神即是先用圆柱座标下的特殊函数对平面波和圆柱散射体的内外域电磁场做无穷级数展开,再藉由特殊函数的加法定理将所有圆柱散射体的展开中心移到同一个展开中心,最后可以得到一组连结整个散射系统的入射电磁场系数及散射电磁场系数的线性方程组,将该组线性方程配合电磁场在散射体边界的连续条件,便可分别求出圆柱阵列中各个圆柱体的内部电磁场与外部散射场,再利用线性叠加原理即可求得整个圆柱系统的全域电磁场分布。

The quality of interior environment in nursing home residents will become one of the attention-getting subjects due to the gradual increase of aging populations This paper directs at the research of nursing home's interior environment factors in Tainan We use the standard of international practice to analyze the intrinsical data of environmental monitoring and establish the characteristics which from environmental physical reaction of nursing home The research items are air environments (PM10 CO CO2 formaldehyde TVOC) temperate environments and light environment (illumination average brightness daylight factor) etc There are the inductive conclusions of this research: 1 In basic medicine the clinical diagnosis means the theory and technique about physical examination with patients The definition of clinical diagnosis in architecture should be the diagnosis of building preserve and improve the feasible way to extend building's service life and assure the residents of the healthy quality of interior environment The object of clinical diagnosis in architecture is not only to ensure the use of structure and environment quality but also keep the structure and environment quality in sustainable; therefore creating an efficient system of preserving plan is needed 2 It is an accurate and technical circumstance which about improving remedying and reconstructing the problems of structure space This circumstance includes finding questions ensuring causation ascertaining ultimate strength evaluating environment quality estimating the necessary of restoration and implementing on a suitable way Furthermore when reconstructing and ameliorating the appearance of structure space it should be respected and the memories of it should be preserved 3 In clinical diagnosis of environment quality of space the question of physical environment and the deficiencies of structure must be separated The structure space of construction and the high quality of space should be inspected strictly then observed the crucial reason that can find out any invisible and hidden causes The diagnosis of construction is to observe the reason of destroyed structure The environmental diagnosis of indoor and outdoor is to find out the crucial reason that influences health 4 In order to decrease the iterant problems the construction and environment of space should be diagnosed However the destruction by natural strength and artificial using by human are important causes that can affect the service life of construction Searching the cause of disease just like curing the patient which includes inspection diagnosis cure and prevention We tested the thermal conductivity of siding material in this research and then found out the roof east vertical face and west vertical face have most radiant heat especially the construction of RC The characteristics of opaquely outer casing have relations with the thermal conductivity of wall to wiz the ability of heat insulation Therefore increasing the efficiency of heat insulation and decreasing the endoergic factor of insolation are very important to temperate environments

而随著国内老年人人口逐渐增加,逐渐迈向高龄化之同时,对於高龄者使用空间之室内环境品质相关议题之探讨,亦成为未来我们需加以关注之议题之一。主要为针对台南某安养中心室内环境因子进行检测调查工作,利用现场室内环境测定以取得有效的实测数据;再藉由汇整相关国际评估基准,并进行实测数据比对分析,建立老人安养中心对物理环境反应之特性。并以前期相关研究文献回顾与老人安养中心实测案例现场的实验,来了解不同空间物理环境特性之影响,并将结果回馈实际建筑及室内设计之用。调查工作项目包含:空气环境之PM10、CO、CO2、甲醛、TVOC;温热环境之室内温度、相对湿度、人体PMV、PPD;光环境之照度、均齐度、昼光率等因子调查。本研究结果可归纳以下几点结论: 1 所谓临床诊断医学乃相对於基础医学而言,是指实际与病人接触的医疗及护理行为中牵涉到的理论和技术;而建筑的临床诊断的定义应为建筑本体与室内外诊断、维护及改善所有可行的方式来延长建筑物的寿命,并确保人与室内环境空间品质的健康。建筑临床诊断目的为确保结构体与环境品质能继续使用,而能维持所需要的效能及承受能力。一个有效的维护计画体系是必须建立的 2 在建筑空间之问题改善、治疗与修复执行中,是一个精确与技术性的事项,其中包含找出问题、确定原因、评估结构应力强度、评估环境品质、评估修复与改善必要性、选择及执行一个适当的过程。其改善与修复也必须尊重建筑空间原有色彩与形貌,并保留原有记忆及文化。 3 在临床诊断中空间环境品质中,物理性环境问题与结构构件缺陷必须分别判断,诊断建筑空间之结构与空间舒适品质必须详细观察其症结性问题,才能发现任何隐藏及有潜伏性缺陷的原因。建筑本体诊断是观察出建筑本体之破坏原因,而是内外空间环境诊断目的在於的找出影响健康因素之症结性问题。 4 建筑本体与空间环境之预防评估目的为降低与抑制问题的再发生。然而,自然力的破坏与人为使用因素皆是影响建筑生命期之主要因素,找出病源问题就如同医生对病人的处理,包含了侦查、诊断、治疗以及预防。 5 本研究以外墙材料热传导率测试结果发现,屋面与东西向立面是承受辐射热最多的地方,尤以 RC 的建筑更甚,不透明部分的外壳能特性主要与壁体的热传透率即隔热能力有关,但是承受来自日射的吸热影响,因此增加隔热性能与降低日射吸热因子是对温热环境是非常重要的。

It is related that the large button with the high sculpture and the thick edge, but the thickness of button, sculpture, edge and other part of back are so different that the thickness of oxide layer on these different part are not equal.

因这些镜种的背面全部都是以钮为中心往下凹,而镜面的铸态毛坯却是平面;这就形成了镜体中心薄,越往外缘越厚的铸件;为使磨制出的镜面没有铸造缺陷,也为了尽量减少镜体重量,须将镜面中心少磨削、外围多磨削。

The invention concerns an artificial block comprising a central core (1) having first (11) and second (12) opposite surfaces each provided with an anvil-shaped side leg (21, 22) with a table (21A, 22A), two sloping sides (21E, 21G; 22E, 22G) and two side surfaces (21B, 21C; 22B, 22C), the tables of said side legs being arranged parallel to said first and second opposite surfaces of the core, the inclined sides of said side legs resting on third (13) and fourth (14) exposed opposite surfaces of said core, said core having fifth (15) and sixth (16) surfaces each provided with side legs and front legs shaped like a truncated pyramid with four side surfaces and one front surface (33) parallel to said fifth and sixth surfaces of the core and to the side surfaces of the side legs.

一种保护层块料,包括一个中心核体(1),有相对的第一面(11)及第二面(12),每一面上各有一个砧状侧凸起(21,22),这两个侧凸起各有一个台面(21A;22A)、两个斜面(21E,21G;22E,22G)和两个侧面(21B,21C;22B,22C),所述台面相互平行,而且平行于所述中心核体的相对的第一面及第二面,所述侧凸起的斜面支撑于所述核体的相对的可见的第三(13)和第四面(14)。所述核体还有相对的第五(15)和第六面(16),其上各有一个锥台状的前凸起,该前凸起有四个侧面和一个前表面(33),该前表面平行于所述核体的第五和第六面,还平行于侧凸起的侧面。

The metal ions of the dinuclear copper complex of [Cu_2_2Cl_4] are linked by two N~1,N~2 1,2,4-triazole bridges,and the central Cu ions have distorted trigonal bipyramid geometries. The central Cu ion of [CuL22]·H2O has a centrosymmetric and distorted tetragonal-octahedral geometry. The metal ions of the dinuclear manganese complex of [Mn_2L_2_2Cl_2(H_2O)_2] are bridged by two chlorine atoms, and the central Mn ions have distorted tetragonal-octahedral geometries. Part III.

配合物[Cu_2_2Cl_4]是通过配体L的1,2,4-三唑环上两个氮原子(N~1,N~2)桥联形成的双桥双核配合物,每个中心铜离子都具有畸变的三角双锥构型;配合物[CuL22]·H_2O的中心铜离子具有中心对称的畸变八面体构型;配合物[Mn2L2_2Cl_2(H_2O)2]是通过两个氯原子桥联形成的双桥双核配合物,每个中心锰离子都具有畸变的八面体构型。

In the rice leaves infected by RDV Yunnan isolate, the distribution of cells full of virus particles formed a belt which was a center of infection and multiplication of virus, around the cells fall of virus particles were some cells with the different extent of lesion as follows: disappearance of membrane system of chloroplasts, there were virus particles in some chloroplasts, and some sine or assembled virions in the mitochodria or cytoplasma but not in nuclei ,and intact subcellular structure in the cell far away from the infected center; In the rice leaves cell infected by Zhejiang isolate, some cells were full of virions, but the distribution of cells didn't form the belt, other cytopathological characters were similar to the cells infected by Yunnan isolate.

RDV云南分离株浸染的水稻叶片中,充满病毒粒体的细胞呈条带状分布,呈现出明显的侵染和增殖中心,在充满病毒粒体的细胞周围,相邻细胞有不同程度的病变,叶绿体膜系统消失,部分叶绿体中含有病毒颖粒,线粒体残体及细胞质中有分散或聚集的病毒粒体,细胞核中未见病毒粒体,离侵染中心较远的细胞中亚细胞结构较完整;RDV浙江分离株侵染的水稻叶片中,部分细胞充满病毒粒体,无明显的条带状分布,其他细胞病理特征与RDV云南分离株侵染的水稻叶片相似。

We can compute three dimensionalvelocity distribution on a planar domain of flow field based on conventional ParticleImage Velocimetryand 3D reconstruction theory of stereophotogrammetry.

在流场空间两个不完全交叠的体积元(映射为两个摄影机象平面上以同名点为中心的两个相同大小的判读小区域)中的示踪粒子的统计性质都能同样表征这两个体积元公共中心的流体运动的假设下,PIV技术与体视三维重建理论的结合,可以将原PIV技术中二维统计平均的概念扩展为三维统计平均,并且在确定体积元公共中心位置之后,直接实现空间流体体元的三维位移重建。

This chapter starts with the determination of primary sense of under. Then it focuses on how its spatial senses are extended from the central image schema to its transformations by metonymy. Next, this part also focuses on how its metaphorical senses are extended in terms of the central image schema and transformations by metaphor. In these analyses, this thesis summarizes four kinds of relations: the relation of UP-DOWN, the relation of HIGH-LOW, COVERING relation or the relation of IN-OUT and the relation of SOURCE-PATH-GOAL. Lots of metaphorical senses of under are derived from these basic spatial relations. In this thesis, the relations between the senses derived from central image schema and those derived from its transformations are explored at length. The relations between the spatial senses derived from central image schema and transformations and the metaphorical senses derived from them are also explored at length. The above analyses demonstrate that the sense extension of the spatial preposition is motivated by image schema, which also provides the root for metonymic and metaphorical extension. The semantic network of under is diagramed finally.

论文首先确定了under的首要意义;然后集中探讨了它的空间意义如何从中心意象图式,通过转喻形成许多变体,从而得以延伸;接着分析了它的隐喻意义如何从中心意象图式及其变体通过隐喻而得以延伸,在此分析中,本论文总结了四种关系:上—下关系﹑高—低关系﹑覆盖关系或里—外关系和起点—路径—目标关系,under的很多隐喻意义源于这些基本的空间关系;本论文还对源于中心意象图式的空间意义与源于其变体的空间意义的关系进行了详细的剖析;对源于中心意象图式与其变体的空间意义及其延伸的隐喻意义之间的关系,也同样进行了详细的剖析;通过分析论证了,意象图式是空间介词义项扩展的源泉,同时也为转喻和隐喻提供了基础;最后得出under的语义网络。

The disc type counter current chromatographic separation column comprises at least a or a plurality of discs provided with designing slots, clapboards at two sides of each disc, the cylinder rotating axis, an upper flange and a lower flange; the cylinder rotating axis is hollow and passes through the center of the upper flange, the lower flange, the discs and the clapboards; the inner edge and the outer edge of the upper flange, the lower flange, the discs and the clapboards are provided with a plurality of bolt pieces that fix the upper flange, the lower flange, the discs and the clapboards together.

一种多功能高效逆流色谱仪,它由盘式逆流色谱分离柱、配重体、行星架、柱体自转轴、行星轮、中心轮、中心公转轴、电机、传动装置、速度控制装置和保温机箱组成;所述的盘式逆流色谱分离柱,它包括有至少一个或多个设槽的圆盘、每个圆盘两侧的隔板、柱体自转轴和上法兰、下法兰;所述的柱体自转轴为空心,贯穿在上法兰、下法兰、圆盘及隔板的中心;在上法兰、下法兰、圆盘及隔板的内外边缘设有多个螺栓部件,将上、下法兰、圆盘及隔板固定在一起。

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推荐网络例句

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm~150rpm时取得最大值,此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世,形体几无变化。

When I was in school, the rabbi explained everythingin the Bible two different ways.

当我上学的时候,老师解释《圣经》用两种不同的方法。