中心体

Spinal neurological involvement was defined by the neurological examination findings suggestive of spinal localization such as paraparesis, sensory deficits indicating a spinal level and sphincter and/or sexual dysfunction or a combination of them.

本研究收集了自1984年以来我院神经白塞病中心收治的所有白塞病脊髓受累患者；所有患者均符合国际白塞病研究小组确定的白塞病诊断标准；同时，通过检查有无脊髓定位体征如截瘫、感觉平面、括约肌和/或性功能障碍等，来确定患者是否有脊髓受累。

Cases 1-5 who presented with spastic paraparesis and other prominent upper motor neurone signs showed high signal on T1-weighted images in the centrum semiovale, corona radiata and posterior limb of the internal capsule which corresponded to the large myelinated fibres of the corticospinal tract Fig.

病例1~5患者表现为下肢痉挛性轻瘫和其他一些明显的上运动神经元症状体征，在T1像上于半卵圆中心、放射冠、内囊后肢处的皮质脊髓束大有髓纤维走行区均可见高信号病灶（图1），在T2、PdWI像上也可见自放射冠延伸至大脑脚的高信号病灶。

The structure of the compound 〓(1) consists of a pentanuclear molecule which is center-symmetric. One W atom is coordinated by four S atoms and two Cu atom. As expected, the Fe atoms are sandwiched between two staggered pentadiene rings. The most interesting aspect of the structure is that Fe-C-P-Cu-P-Cconstitutes a distorted hexagon and Fe-Cu-W-Cu-Fe is nearly in a line.

结构是以W原子为对称中心含有五个金属原子的线型结构，W原子与四个μ〓-S和两个Cu原子配位；Fe原子在两个戊二烯环中间形成一个三明治夹心结构；Fe〓-C〓-P〓-Cu〓-P〓-C〓-构成扭曲的六边形，由于两边1，1'-双二茂铁配体的作用导致Cu-S键的拉长。

The results were as follows: Compared with control group, the weight and the relative weight of thymuses, bursas of Fabricius and spleens of experiment group increased significantly(P＜0.05) or extremely significantly(P＜0.01). In experiment group, the cortex of thymic lobule, bursa nodule and Periarterial Lymphatic Sheaths thicken obviously; the volume of bursa nodule, splenic nodule and ellipsoid augmented, and the germinal center of splenic nodule were obvious; the thymic corpuscle increased; the plica of bursas of Fabricius developed well and the degenerating of it retarded.

结果表明：试验组鸡胸腺、腔上囊、脾的重量和器官指数均高于对照组，差异显著(P＜0.05)或极显著(P＜0.01)；试验组的胸腺小叶皮质增厚，胸腺小体增多；腔上囊皱襞发达，腔上囊小结体积大，皮质较厚，退化延缓；脾的动脉周围淋巴鞘增厚，脾小结体积大，生发中心明显，椭球增大。

A little of the diaylsed solution was dilluted with distilled water (1:4) and applied to metallic sample plate following negative staining with sodium phosphotungstate solution. The sample was freeze-dried and examined by transmission electron microscopy 1.4 IFvs size and size distribution measured 1.5 The shape morphology of IFvs 1.6 Measureing the encapsulation efficiency and loading capacity of Liposomal Gd-DTPA A sample volume of 5ml was sent to analyze (Zhongshan University Analytical Center, Guangzhou).

1.6 Gd-DTPA脂质体包封率及载药量的测定取5ml前述离心后所得上清液送交中山大学分析测试中心，采用高频电感耦合等离子发射光谱法测定离心液中Gd-DTPA含量，用加入总的Gd-DTPA量减去离心液中的Gd-DTPA含量即得包封量。

The conductive coordinative polymolecular compounds,which contain thetransition metal ions〓and〓as central metal ions,transition metal ionsor rare earth ions as counter cations and〓or〓as ligand,have been synthesized.

合成出以过渡金属〓、〓、〓、〓和〓作为中心金属离子、过渡金属或稀土离子作为抗衡阳离子、有机小分子〓或〓作为配体的导电性配位高分子化合物，它们均为能在空气中稳定存在且难溶和难熔的无定形粉末状固体。

On its own, polysomy 17 was not associated with HER-2 overexpression on IHC or increased HER2 mRNA levels by RT-PCR. Moreover, and in contrast with HER2 gene amplification, polysomy 17 was not associated with high tumor grade, hormone receptor negativity, or reduced disease-free survival.Conclusion: Polysomy 17 affects HER-2 testing in breast cancer and is a major cause of equivocal results by FISH.

不过，在J Clin Oncol同期配发的一篇述评中，美国波士顿大学医学中心的罗森伯格指出，当务之急不是直接进行这样的研究，而是应该对已有研究的IHC、FISH和有效率数据进行回顾或再分析，以明确是否无HER2扩增的17号染色体多体肿瘤被归入不同类别(HER2阴性、阳性)，并由此导致关于HER2靶向治疗疗效的结果不一致。

Heavy Scintillator PbWO〓 is the scintillating material to be used in the new generation of particle physics experiments at the large hadron collider in CERN. The scintillant properties of PbWO〓 are very sensitive to its structure.

重闪烁体PbWO〓是用于欧洲核子中心正在建造的大型强子对撞机LHC上的紧凑型μ子螺线管探测器的探测材料，它的发光性质和其微结构有着密切的关系。

Second, residues in the reactive site of the inhibitor were replaced by the consensus substrate recognition sequence of furin, namely, Arg at P_1, Lys at P_2, Arg at P_4 and Arg at P_6. In addition, the P_7 residue Asp was substituted with Ala to avoid possible electrostatic interference with furin inhibition. Finally, the extra N and C terminal residues beyond the doubly conjugated disulfide loops were further truncated. However, all resultant synthetic peptides were found to be temporary inhibitors of furin and kexin during a prolonged incubation, with the scissile peptide bond between P1 and P'1 cleaved to different extents by the enzymes.

高活性、低分子量的furin酶抑制剂有可能发展成为新型的抗细菌内毒素和抗病毒感染的药物，我们以绿豆胰蛋白酶抑制剂Lys片段长链22肽为模板，设计了一系列能抑制furin和kexin活性的突变体，采用如下三种方法逐步优化：一、去除Lys片段长链三对二硫键中的一对，用Ser替换Cys，减少可能存在的二硫键错误配对；二、抑制剂的活性中心根据furin底物的专一性逐步改变，即P1、P2、P4和P6位分别变为Arg、Lys、Arg和Arg，同时为了避免P7 Asp和P6 Arg之间可能存在的相互作用，将P7位Asp替换为Ala；三、将两对二硫键形成的双环的外面5个氨基酸残基去除。

The reactions of pyridine-2-carbaldehyde semicarbazone with transition metal Ni(II,Cosalts afford two pyridine-2-carbaldehyde semicarbazone transition metal compounds.

配合物[CoL2]·(ClO4)2·H2O(3)，分子式C14H18Cl2CoN8O11，Mr=604.19，属三斜晶系，空间群P-1，晶胞参数：a=9.984(3) A， b=11.082(4) A， c=12.196(5) A ，Dc=1.769Mg/m3，α=112.954(4)°，β=110.050(4)°，γ=94.017(3)°，V=1134.4(7) A3， Z=2，μ=1.067mm-1， F(000)=614，结构偏离因子R=0.0501 和ωR=0.1028，配合物(3)的中心金属离子采取六配位的变形八面体。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了