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It has been proposed that extra centrosomes generate CIN by promoting multipolar anaphase, a highly abnormal division that produces three or more aneuploid daughter cells.

人们长期所持的一个观点是,额外的中心体通过诱导混乱的多极纺锤体组装和非对称的细胞分裂来促使染色体错误分离。

3H-TdR pulse labeling and autoradiograph results and Gimsa stained results suggest that the DNA synthesis, chromosome condensation are not affected in HAP42 multinulceuse cells.

以α-Tubulin和人类自身抗中心体免疫血清进行免疫荧光染色发现多核细胞中有单极纺锤体的形成,γ-tubulin分布比对照细胞弥散,着色较弱。

Moreover, it targets to the second mother centriole in late S or G2 phase during centrosome duplication, with a timing later than ninein but earlier than dynactin.

中心体复制时,Nudel 在S/G2 的晚期才定位到新生的中心粒上,它比ninein 晚但比dynactin 要早些。

Reduction of the diploid number of chromosomes by one half during meiosis, resulting in the haploid number.

星状体在细胞浆内形成的星状结构,在有丝分裂期间有棱形纤维环绕中心体

This domain is present in proteins associated with cilia,flagella,the centrosome,and the Golgi complex,and possesses a microtubule-binding function.

含有这个结构域的蛋白通常与纤毛、鞭毛、中心体、以及高尔基体有关,并具有结合微管的功能。

After prolonged exposure to ANE, the accumulation of hyperploid cells, micronucleated or multinucleated cells were noted concomitantly with centrosome amplification.

另外,长时间的作用下多倍体,多核或微核细胞之有明显的增多,同时也发现常之中心体

Futhermore, using indirect immunofluorescence to determine the centrin localization in trochophore cell and we found that many cluster centrin spots locate at cytoplasm.

我们用间接免疫荧光还检测了单环刺螠担轮幼虫分散的单细胞的Centrin表达,结果显示,除在中心体中有定位外,在纤毛基体中有Centrin定位。

We found that the centrosome loses its function as a microtubule organizing center during development of rodent hippocampal neurons.

我们发现在臼齿动物海马神经元形成过程中中心体失去了其作为微管组装中心的功能。

Centrosome A structure found in all eukaryotic cells, except fungi, that forms the SPINDLE during cell division.

中心体:在除真菌以外的所有真核细胞中存在一种结构,在细胞分裂时可以形成纺锤体。

To define the mechanism underlying this mitotic defect, we generated cells that differ only in their centrosome number.

相反,额外中心体癌细胞仅仅是经过一个过渡性的多极纺锤体阶段,在这个阶段,&异常动粒微管附着体&会积累。

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