个体化

Wavefront measurement and iris registration were performed in the upright position with Wavescan aberrometer,and another iris registration was performed in the supine position during the operation with VISX Star S4 IR.

方法选择接受双眼CustomVueTM个体化角膜屈光手术的近视患者86例172眼，术前应用Wavesan像差测量仪在坐位时进行虹膜识别，术中应用VISX Star S4 IR进行卧位时虹膜定位，记录眼球旋转及瞳孔中心移位。

Conclusion］Philos plate for proxima humeral fracture using acromial anterior lateral deltoid splitting approach possesses such advantages as better individuation,less disturbance of the blood supply,stable fixation of the fracture.

1%。［结论］肩峰下前外侧经三角肌分离入路运用Philos接骨板具有个体化强、血运破坏少、固定可靠等优点，是治疗肱骨近端骨折的一种新方法。

According to different ages and MDI, we could provide a suit of personal aimful specific training progrom with plenfful pictures and suggestions on nutrition.

根据小儿不同年龄、不同智能发育指数，给家长打印出图文并茂针对性强的个体化有目的的具体训练方案及营养指导建议。

DCs acquired by our reformed methods express both CD83 and CD 14 molecules highly, and have a higher density than other domestic reports. The higher TNF in DCs culture medium of HC patient suggests DCs in patient still have antigen presenting ability and by optimization the culture medium would improve its presenting ability and have a potential value in design and application individual vaccine. Although antigens pulsed DCs have a decrescent antigen presenting ability but BCG HSP70 could induce its mature and improve its presenting ability. Suggests BCG HSP70 would be a useful mature inducer. Lymphocytes primed by DCs based HC vaccine have the specific cytotoxicity against HCC lines. The CTL after freezing and anabiotic could prophylaxis and therapy HC xenograft on nude mouse. The results also suggests that CD4〓 lymphocytes play a important role in HC with a good differentiation and would be useful in treatment this kind of HC. After being activated by Peptide LLNQHACAV of hAFP and apoptotic HCCs pulsed DCs respectively, the culture medium of activated lymphocytes both contains a high level Th1 cytokines IL-12 and TNF. Primed lymphocytes appeared a characteristic of NK cells. DCs not only inhibited the growth of human HCC and other cancer cells in vitro but also prevented the growth of HC xenograft on nude mouse in vivo. There are at least three kinds of mechanism playing important role in DC based vaccine ,there are inhibition of DCs, HC specific CTL and cytokines pathway.

诱导出的DC共同表达CD83和CD14分子，CD83分子表达明显高于国内报道；肝癌患者DC培养上清中TNF水平高于健康人，提示肝癌患者DC仍具一定的抗原呈递能力，适当调控可使其行使APC功能，以期在肝癌个体化疫苗中发挥作用；DC负载肝癌可溶性抗原后，抗原呈递能力降低，BCG HSP70可促进DC成熟，增加其抗原呈递能力，预示BCG HSP70有可能成为促进DC活化和成熟的另一重要分子；肝癌DC疫苗在体外诱导肝癌特异性淋巴细胞，活化的淋巴细胞在体外对肝癌细胞的杀伤以特异性CTL为主，同时分泌较高水平Th1型细胞因子IL-12和TNF，并抑制4种肝癌细胞生长；冷冻复苏后的肝癌特异性淋巴细胞可以预防和抑制人肝癌裸鼠皮下移植瘤，提示DC负载肝癌可溶性抗原后诱发的MHC-Ⅱ类限制性CD4〓T细胞有可能在分化程度高的肝癌治疗中发挥作用；用DC和HLA-A2〓DC分别负载凋亡肝癌细胞和hAFP218-226位LLNQHACAV HLA-A2限制性九肽，在体外诱导肝癌特异性淋巴细胞，活化后的CTL细胞分泌较高水平的Th1型细胞因子IL-12和TNF，并具较强杀伤活性，此CTL同时具备NK细胞特征；DC对肿瘤细胞的抑制作用可能是通过吞噬实现的，Fas-L在DC抑制中也起一定作用；DC对人肝癌裸鼠皮下移植瘤的抑制率为97％；在肝癌DC疫苗的作用中，至少联合3种以上机制，即通过DC的直接作用、肝癌特异性CTL和细胞因子途径直接或间接地杀伤和抑制肝癌细胞。

These findings underscore the need of individualized antiplatelet treatment regimens in diabetic patients.

这些结果都强调了对于糖尿病患者抗血小板治疗方案的个体化需要。

It is significantly important to applicate gene polymorphism to the theoretical foundation and clinical research on hypertension individual drug treatment.

应用基因多态性探讨高血压个体化治疗方案的基础与临床研究具有重要的意义。

Background and Purpose— Most acute ischemic stroke patients arrie after the 3-hour time window for recombinant tissue plasminogen actiator administration.

中风的时间窗已经延长至9小时，而且在不久的将来可能会更加延长，随着神经影像的发展，个体化治疗将真正成为现实。

Hepatic vascular exclusion with preservation of the caval flow for liver resection.

原发性肝癌要按个体化采用以手术为主的综合治疗。

Crania drilling hematoma evacuation drainage is easy and effective in the treat-ment of intracranial hamatoma but its clinical application should differ from person to person and personalized plan is required.

颅骨钻孔血肿清除引流术是治疗颅内血肿的一种简单有效的方法，但临床实施该技术要因人而宜，讲求个体化方案。

Key words: upper eyelid; dermatolysis; blepharoplasty; individuation

上睑；皮肤松弛；睑成形术；个体化

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。