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Over the past year, the group evaluated the seven-year follow-up results of therapeutic effects of all-trans retinoic acid and arsenic trioxide (As2O3) combined treatment in newly diagnosed acute promyelocytic leukemia. We also studied the mechanism of therapeutic effects of Imatinib and As4S4 combined treatment in CML cell line and animal model. These two papers were published on PNAS.

过去的一年中,本课题组总结完成了全反式维甲酸和三氧化二砷联合治疗初发急性早幼粒细胞白血病的七年临床随访资料的疗效评估;在慢性粒细胞性白血病,完成了应用As4S4和STI571联合治疗作用的细胞、分子和整体动物水平的机制研究,这两部分工作均已发表于PNAS。

In animal and protoctist cells the centrosome contains two short barrel-shaped structures, the CENTRIOLES, but these are not directly involved in spindle formation.

在动物和原生生物的细胞中,中心体包含两个短的圆筒状的小体-中心粒,但它们和纺锤体的形成并没有直接的关系。

It was confirmed by Log-rank test that the cardiac allografts in group B and group C all survived longer than those in group A significantly (p.01). The survival time of the cardiac allografts in group C was also longer than those in groups B (p.05), which suggested that the recipients which pretreatment with SPC and CP was more efficient than that with CsA.(2)TGF-β1 is expressed as buffy granules in cardiac muscle and blood vessel dissepiment.

对数秩检验(log-rank test)证实,B组移植心脏的存活时间较A组明显延长,差异具有极显著性(P.01);C组移植心脏的存活时间较A组也明显延长,差异极其显著(P.01);将B、C两组移植心脏的存活时间进行比较时表明二者之间仍具有显著性差异(P.05),说明SPC和CP联合预处理对移植心脏的存活时间的延长效果优于应用免疫抑制剂CsA组。2)TGF-β1阳性表现为心肌细胞浆及血管壁内出现棕黄色颗粒。

This experiment selects material E14d SD the big mouse SVZ nerve stemcell as well as P7d the SD big mouse internal ear stem cell, does nothave the blood serum complete culture medium raise through D-MEM/F12to cause its massive multiplication, a part carries on Nestin, NF,CNP, GFAP, MAP-2, Myosin, the P27 immunity group, proved the raise thenerve stem cell has many to the split up ON potential; Another partdyes EGFP after the extension to carry on the guinea pig internal earto transplant, after two weeks fills the class to take the cochleafixed slice observation, discovered has the stem cell ball group inthe internal ear survival, proved the nerve stem cellheterotransplantation the possibility and for transplants the stemcell migration differentiation repair hair cell damage the thoroughresearch accumulation experiment experience.

本实验取材E14d SD大鼠SVZ神经干细胞以及P7d SD大鼠内耳干细胞,通过D-MEM/F12无血清完全培养基培养使其大量增殖,一部分进行Nestin、NF、CNP、GFAP、MAP-2、Myosin、P27免疫组化,证明培养的神经干细胞具有多向分化的潜能;另一部分通过转染EGFP后进行豚鼠内耳移植,两周后灌流取耳蜗固定切片观察,发现有干细胞球团在内耳存活,证明神经干细胞异体移植的可能性并为移植干细胞迁移分化修复毛细胞损伤的深入研究积累实验经验。

Bate G B,et al.Microdissection and microcloning from the short arm of human chromosome 2,Mol[J].Cell Biol,1986,6:3826~3830.[4] Guan X Y,et al.Chromosome microdissection identifies cryptic sites of DNA sequence amplification in human ovarian carcinoma[J].

染色体微切割、微分离及微克隆技术在细胞遗传学和分子生物学之间架起一座新的桥梁,结合其他先进技术和方法,将加速这两门学科的更深层次的发展[33]。

DISCUSSION The copper response has been deeply studied so far with two bacteria, E. coli and Enterococcus hirae (33, 37, 39), but the elucidation of the copper systems in M. xanthus will provide a missing piece in the complicated puzzle of bacterial adaptation to this metal under natural environmental conditions: how do cells handle different copper concentrations during a complete life cycle?

讨论 铜的反应一直深入研究,所以到目前为止,有两名细菌,大肠杆菌和肠球菌平江( 33 , 37 , 39 ),但澄清铜系统米细菌将提供一个一块失踪,在纷繁复杂的拼图细菌适应这下金属的自然环境条件:怎么处理细胞不同铜浓度,在一个完整的生命周期?

"Here we have two variants that have no impact on pigmentation and only affect the risk of basal cell carcinoma," Kari Stefansson, Decode's chief executive, who led the study, said in a telephone interview.

解码基因机构主任、这项研究的领导人凯里-斯蒂芬森Kari Stefansson)在一次电话采访中说:我们发现的这两个基因变异对色素沉着并无作用,仅仅影响患皮肤基底细胞癌的风险。

Methods firstly, twenty female wistar rats were divided into 2 groups at random. each rat in des group (a0) was subcutaneously implanted with des encapsulated in silastic tube. each rat in control group (b0) was implanted with blank silastic tube. after 8 weeks, all the animals were sacrificed for weight of the pituitary gland, serum prolactin level, prl-immunoreactive cell count and cyclin d1 expression in prolactinoma.

首先将20只雌性wistar大鼠分为皮下植入含des硅胶管的des组(a0组)及皮下植入空白硅胶管的空白对照组(b0组)。8周后处死所有大鼠,观察并比较两组大鼠的血清prl水平、垂体质量、垂体中prl蛋白分布及细胞周期素d1 (cyclin d1)的表达。

Hamm and Leeuwenhoek were the first scientists to observe human sperm cells using an improved microscope in 1677 (more than 1000 years after Muhammad ).

公元1677年,两位科学家翰姆和列恩福克首先使用改进后的显微镜观察人类的精子细胞(在穆罕默德年代的1000多年之后)。

Pasteur agreed with these views, but could not convince two very powerful and influential German chemists, Justus Von Liebig and Friedrich Wohler.

这两个科学家认为,糖的消耗是由即将死去的酵母细胞所分泌的物质引起的。

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We have no common name for a mime of Sophron or Xenarchus and a Socratic Conversation; and we should still be without one even if the imitation in the two instances were in trimeters or elegiacs or some other kind of verse--though it is the way with people to tack on 'poet' to the name of a metre, and talk of elegiac-poets and epic-poets, thinking that they call them poets not by reason of the imitative nature of their work, but indiscriminately by reason of the metre they write in.

索夫农 、森那库斯和苏格拉底式的对话采用的模仿没有一个公共的名称;三音步诗、挽歌体或其他类型的诗的模仿也没有——人们把&诗人&这一名词和格律名称结合到一起,称之为挽歌体诗人或者史诗诗人,他们被称为诗人,似乎只是因为遵守格律写作,而非他们作品的模仿本质。

The relationship between communicative competence and grammar teaching should be that of the ends and the means.

交际能力和语法的关系应该是目标与途径的关系。

This is not paper type of business,it's people business,with such huge money involved.

这不是纸上谈兵式的交易,这是人与人的业务,而且涉及金额巨大。