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Oligodendrogliomas provide a unique model to study the molecular basis of chemoresistance, as there are two distinct genetic subtypes with significant differences in chemosensitivity.

少突胶质细胞瘤提供了一种独一无二的模型来研究药物抵抗的分子基础,因为其中存在了两种在药物敏感性方面有显著差异的独特基因亚型。

However, alkylating agents, such as cyclophosphamide, and the topoisomerase II inhibitors, doxorubicin and epirubicin, are associated with two types of cytogenetically distinct leukemias after adjuvant chemotherapy.

然而,烷化剂如环磷酰胺、拓扑异构酶II抑制剂、阿霉素、表阿霉素都与辅助化疗后的两种细胞遗传学不同的白血病的发生相关。

The big difference between these two alternatie ways that tumour cells use to inactiate tumour suppressor genes is that, while the reersal of genetic alterations is technically almost unfeasible in clinical scenarios, the function of these epigenetically inactiated suppressor genes is easily reactiated by pharmacological means.

这两种改变方式最大的不同之处在于肿瘤细胞利用失活的肿瘤抑制基因,而在同时相反的遗传学改变在临床方案上是很难实施的技术。

Porcine hemoglobin polymer is made in imitation as the substtitute for blood product. Pseudorabies virus is chosen as the enveloped DNA model virus and the Porcine Parvovirus is chosen as the nonenveloped DNA model virus. Complete DNA sequences of these two kinds of virus are analyzed and specific fragments are selected as examinable targets. Establish a new method based on real time PCR combined with cell infection assay to evaluate virus clearance efficiency in blood product.A new method is established to remove the virus from blood product.

本研究以戊二醛聚合猪血红蛋白模拟血液制品,选取PRV、PPV分别作为血液制品中有包膜DNA指示病毒和无包膜DNA指示病毒,针对特定两种指示病毒PRV、PPV,进行了生物信息学分析,选取特定片段作为扩增靶点进行检测,建立了一种基于实时荧光定量PCR技术的检测方法,联合病毒的细胞感染力实验,用以评价血液制品中指示病毒的灭活去除效率。

Widely separated and loosely clustered irregular but branched glands embedded in broad zones of cellular myofibromatous stroma to those possessing crowded, markedly complex, branching glands separated by sparse intersecting fascicles of fibromuscular tissue.

显微镜下的特点是双相增生,两种成份,子宫内膜腺体和细胞呈非典型性增生,还有子宫肌瘤样间质成份,子宫肌瘤样间质成份弥漫分隔松散的,成片状排列,但不规则的分技状子宫内膜样腺体,这些腺体也可以呈拥挤的,明显复杂性增生。

The increases in the cell density in the sutures of the treated groups were higher as compared to the two controlled groups for 3 7 14days indicating that cellular hyperplasia in the expanded sutures were accelerated by the protraction .The cell density in the palatomaxillary sutures and in the frontomaxillary sutures differed in increase ways at the two time points of 21th day and 28th day suggested that the mode of bone formation in the circummaxillary sutures is different from one another..5 The expression of Proliferating Cell Nuclear Antigen were always higher than the controls in the course of this study,which i

而在21、28天时间点两个骨缝与对照组相比在相同时间点增长程度明显不相一致,提示我们不同的上领骨周围骨缝在前牵引作用下改建方式过程可能不一。5、在上领前牵引作用下,上领骨的额领缝内的PCNA的阳性表达一直高于对照组,提示前牵引促进上领骨周围骨缝内细胞增殖活动增强。

Observation and comparison of two groups' wound healing time, and wound tissue's pathology Score , hydroxyproline content of wound surface granulation ,microphagocyte ratio of wound exudate in healing process.

分别对两组患者的创面愈合时间、愈合过程中创面组织的病理评分、创面肉芽组织羟脯氨酸(hydroxyproline,Hyp)含量及创面渗出液的巨噬细胞比率进行观察比较。

CD44~+CD24~ cells in MCF-7 increased after cultured in serum-free medium. The cancer stem-like cells in MCF-7 grew as clonal nonadherent spherical clusters. The percentage of CD44~+CD24~ cells reached up to 29.23% after cultured 3 weeks in serum-free medium.

结论SP检测与CD44~+CD24~细胞检测是目前乳腺癌干细胞检测的两种常用方法,但两者用于同一种乳腺癌细胞系中的检测结果并不一致,均有一定的局限性。

The sample particles studied in this project include human red blood cells, osmotically swollen into a micro-sphere, with and without treating with N-ethylmaleimide, and at different temperatures, as well as liposomes with different DOPC/cholesterol ratio (1:1 vs.1:3) For spherical RBCs, smaller deformation were observed in samples at room temperature with NEM treatment and samples at 42 ℃without NEM treatment, compared with the deformation of the control set, namely, RBCs at room temperature without NEM treatment.

这可能是由於42 ℃为红血球细胞骨架Spectrin的型态转换温度,Spectrin由tetramer转换成dimer。推测此温度及药物作用下对Spectrin的型态转换可能造成类似的效果。同时以自行合成DOPC/胆固醇比例(1:1)及(3:1)之微脂粒重覆上述之形变实验,发现两种组合比例微脂粒形变率的差异在误差范围内。

The results are: 1 the stricture of the capillaries of stria vascularis was observed in most cochleae of rickety rats and, segmental deletions of the outer hair cells on the first turn of cochlea were found in a small number of rickety rats; 2 the perilymphatic ionized calcium concentration significantly re- duced and the threshold of CAP (Compound Action Poten- tials of the eighth nerve) significantly rose in rickety rats in comparison with those of normal control; 3 gentamicin results in an increase of the perilymphatic ionized calcium concentra- tion in rickety rats; 4 the cochleae of the rickety rats appeared to be less vulnerable to the ototoxicity of gentamicin than the normal one.

研究包括两个方面,其一是&佝偻病的感觉神经性耳聋及其对庆大霉素耳毒性作用的耐受性&,系用大白鼠建立维生素D缺乏性佝偻病动物模型,发现:(1)佝偻病大白鼠耳蜗血管纹毛细血管狭窄,少数动物耳蜗底回外毛细胞有节段性缺失;(2)佝偻病大白鼠的耳蜗鼓阶外淋巴钙离子浓度降低,CAP(听神经复合动作电位,以下简称CAP)听阈提高;(3)庆大霉素可使佝偻病大白鼠耳蜗外淋巴钙离子浓度上升;(4)佝偻病大白鼠耳蜗在功能和形态上都比正常者更能耐受庆大霉素的耳毒性损害。

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We have no common name for a mime of Sophron or Xenarchus and a Socratic Conversation; and we should still be without one even if the imitation in the two instances were in trimeters or elegiacs or some other kind of verse--though it is the way with people to tack on 'poet' to the name of a metre, and talk of elegiac-poets and epic-poets, thinking that they call them poets not by reason of the imitative nature of their work, but indiscriminately by reason of the metre they write in.

索夫农 、森那库斯和苏格拉底式的对话采用的模仿没有一个公共的名称;三音步诗、挽歌体或其他类型的诗的模仿也没有——人们把&诗人&这一名词和格律名称结合到一起,称之为挽歌体诗人或者史诗诗人,他们被称为诗人,似乎只是因为遵守格律写作,而非他们作品的模仿本质。

The relationship between communicative competence and grammar teaching should be that of the ends and the means.

交际能力和语法的关系应该是目标与途径的关系。

This is not paper type of business,it's people business,with such huge money involved.

这不是纸上谈兵式的交易,这是人与人的业务,而且涉及金额巨大。