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The effects of narciclasine isolated from Narcissus tazetta bulb on the growth of two model microorganisms, E.coli and Ceteuisiae fermentum, were studied in this paper. The results revealed that the growth of Ceteuisiae fermentum was obviously inhibited by 20μ.g/mL NCS. The inhibition was about 51%. However, the inhibition of NCS to E.coli growth was hardly observed.

本文以两种模式微生物—大肠杆菌和啤酒酵母为实验材料,对从水仙鳞茎中提取的生物碱Nareiclasine在两种模式微生物生长中的作用进行了比较研究,结果发现在20μg/mL NCS处理下,酵母细胞生长受到明显抑制,抑制率达到51%,而大肠杆菌生长则不受影响。

There are four kind of isoforms of endothelin in human and other mammals named ET-1, ET-2, ET-3 and ET-β, which are slightly different in construction and pharmacological effect. In human beings, ET-1 is the dominative subtypes. ET-1 remains in blood at a low level about 5ng per liter on physical state. It is synthesized, stored, released and metabolized locally. The half-life of ET-1 is about 1 hour. ET-1 is the most potent vasoconstrictive factor till now, and it is more functional in vein than in artery. In vascular bed, there are two kind of ET receptors. Type A mainly located in smooth muscle cells, whereas type B in endothelial cells. The latter can stimulate intimal hyperplasia via a parasecretion way and activate some oncogenes such as c-fos and c-myc and then enhance their expression. These alterations result in constriction of blood vessels, thus the SMC steps into proliferate state from silent state.

人及哺乳动物体内有四种结构及药理学性质略有差异的异物体,分别为ET-1、ET-2、ET-3、ET-β,而在人主要是ET-1,在生理条件下,ET-1在血浆中含量较低,约为5ng〓,故ET-1不是一个循环激素,而是局部合成释放,局部起作用的活性物质,半衰期约1小时,ET-1是目前已知的最强的血管收缩剂,对静脉的作用比动脉强,在血管床,ET受体有A、B两型,A型主要分布在平滑肌细胞,B型主要分布在内皮细胞,它可以通过旁分泌途径刺激内膜增生,具有有丝分裂原效应,可以激活某些癌基因如C-fos、C-myc使其表达增强引起血管收缩,使静止期SMC进入增殖期,还可以通过信号传导途径,与bFGF、GTF-β、PDGF等生长因子协同作用,起共有丝分裂原作用。

Erve growth factor can combine with its" receptor (one of tyrosine protein kinase receptor coded by proto - oncogene tyrosine kinase, TrkA), Causing the molecule of receptors to gather on the cell surface, and the tyrosine protein in cytoplasmic domain may be activated, three tyrosine base in the kinase domain of its" receptor and two tyrosine base at other domain be phosphated, thus, phosphated tyrosine receptor kinase became the bracket which absorb all kinds of connective proteins and kinases.

GF与其酪氨酸受体激酶受体(由原癌基因trk编码的一种酪氨酸蛋白激酶受体,TrkA)相结合,引起受体分子在细胞表面发生二聚体化,然后受体细胞内结构上酪氨酸活性被激活,使受体自身结构中位于激酶结构域的三个酪氨酸残基及在此结构域外的两个酪氨酸残基发生自身磷酸化,这样,磷酸化的酪氨酸受体激酶A便成为吸收各种连接蛋白质和酶的支架。

In order to trace the male cytoplasm transmission during double fertilization process, the mature gametophyte, zygote, proembryo and primary endosperm in Pelargonium hortorum Bailey and Rhododendron mucronulatum Turcz were investigated using transmission electron microscope and DNA staining technique.

本研究应用透射电镜及DNA荧光技术对天竺葵和杜鹃的成熟配子体以及在受精以后雄性细胞器的存在和分布进行了系统的细胞学研究,阐明了这两种植物中雌性生殖单位的超微结构特点及雄性和雌性细胞中质体和线粒体在受精作用中的传递。

Two key advantages of functionalized carbon nanotubes are their strong ability to translocate through plasma membranes and low toxicity, allowing their application in drug and gene transfer system.

功能化的CNTs的两个关键优势在于它具有很强的细胞穿透能力和较低的细胞毒性,使其在药物和基因转运领域中的应用成为可能。

These two peptides can help functional proteins rapidly translocate into cells both in vitro and in vivo in a non-invasive manner, and preserve their biological actions in several cell and animal models.

这两个胜肽链在试管与活体可以以不具侵略性( non-invasive )的方式携带开展型态的功能性蛋白质快速的进入细胞内,并且在许多的细胞与动物实验中均可以保留它们的生物功能。

Two known genes lie within the implicated genetic interval. One is FTO (a locus associated with fat mass and obesity), which has been implicated in nucleic acid demethylation and is highly expressed in the arcuate nucleus of the hypothalamus; the other, called fantom, or FTM (KIAA1005 or RPGRIP1L), begins transcription at a location only 200 base pairs upstream from the 5' end of FTO. FTM is a structural component of the ciliary body, present on all cells, that plays a role in a wide range of cellular and organ functions.9 Elements of the cilium are mutant in Bardet Biedl syndrome, which includes obesity among its characteristic phenotypes.10

有两个已知的基因存在于基因间隔中,一个是FTO(与脂肪体积和肥胖相关的基因位点),它在核酸脱甲基中发挥作用并且在下丘脑弓状核中高表达,另一个称作FTM,其在FTO 5'-末端的上游序列仅200个碱基对中开始转录,FTM是睫状体的结构组成部分,在所有细胞中都要表达,并在细胞和器官功能中发挥广泛的作用。

AIM To study the direct effect of amiloride on recombinant human protein kinase CK2 holoenzyme and its kinetics. METHODS Recombinant human protein kinase CK2 α and β subunits were cloned,expressed and purified by gene engineering.

蛋白激酶CK2是一种真核细胞内普遍存在的信使非依赖性丝氨酸蛋白激酶,是由两个催化亚基和两个调节亚基组成的异源四聚体(α2 β2 、α′2 β2 或αα′β2 ) [1,2 ] 。

Marston, MD, from the University of North Carolina School of Medicine in Chapel Hill, and colleagues."Dermagraft is a bioengineered dermal substitute that laboratory data suggest has two principal modes of action. It provides living, human dermal fibroblasts that deposit matrix proteins and facilitate angiogenesis. It also provides a preformed collagen matrix, receptors, and bound growth factors that facilitate the migration of the patients' epithelial cells that close the wound."

Marston医师及同事表示,针对治疗慢性溃疡的生理失能的患者,还需要更多有效的疗法,而人工皮肤就是一种生物工程皮肤代用品,这一项实验室数据显示两种最重要的功能模式,它提供活体人类皮肤纤维组织母细胞,储存母体蛋白质并促进血管新生,另外它也提供预先形成的胶原母体、接受器及束缚成长因子,帮助病患的上皮细胞移动,使伤口愈合。

Prostratin and the DPP as early as the 1990s were from the rain forests and arid regions of the two resin plant extract, when scientists discovered through research, Prostratin have two effects, first of all, it can to reduce the secretion of cells by HIV Body so that the AIDS infection rate of decline Secondly, it can be extracted hidden in immune cells within the AIDS virus.

Prostratin和DPP早在上世纪九十年代分别从雨林和干旱地区的两种树脂类植物中提取出来,当时科学家通过研究发现,Prostratin有两种功效,首先,它能促使体细胞减少分泌艾滋病病毒受体,使艾滋病感染率下降;其次,它可以逼出隐藏在免疫细胞内的艾滋病病毒。

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The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了,排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意,我建议我们在价格上大家各让一半。

After an hour and no pup, look for continued contractions and arching of the back with no pup as a sign of trouble.

一个小时后,并没有任何的PUP ,寻找继续收缩和拱的背面没有任何的PUP作为一个注册的麻烦。