两细胞的

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗(来源：A44B8787C论文网www.abclunwen.com)功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

Review articles only; ear; acoustic; hearing loss; deafness; ototoxicity; otorhinolaryngeal; vestibulocochlear; cochlea; sound; bioacoustics; organ of Corti; semicircular canals; cochlear implants; binaural; monaural; tympanic; malleus; incus; stapes; ear drum; geniculate; inner ear hair cells; outer hair cells; round window; oval window

唯一综述；听觉；声学的；听力损失聋的；耳毒性；otorhinolaryngeal；前庭蜗；耳蜗；声音；生物声学的；柯替氏器；半规管；耳蜗植入管；两耳的；单耳的；鼓膜的；锤骨；砧骨；镫骨；耳鼓；膝状的；内耳毛细胞；外毛细胞；圆窗；卵圆窗

Ear; acoustic; hearing loss; deafness; ototoxicity; otorhinolaryngeal; vestibulocochlear; cochlea; sound; bioacoustics; organ of Corti; semicircular canals; cochlear implants; binaural; monaural; tympanic; malleus; incus; stapes; ear drum; geniculate; inner ear hair cells; outer hair cells; round window; oval window

听觉；声学的；听力损失；聋的；耳毒性；otorhinolaryngeal；前庭蜗；耳蜗；声音；生物声学的；柯替氏器；半规管；耳蜗植入管；两耳的；单耳的；鼓膜的；锤骨；砧骨；stapes；耳鼓；膝状的；内耳毛细胞；外毛细胞；圆窗；卵圆窗

These results indicated that the two weedicide could not only damage cytomembrane construct and increase cytomembrane permeability which can lead to lose the water in cell .hut also affect the capability of plant to transfer materials and resulted in the plants dead finally.

这表明，这两种除草剂在各自作用的植物体内部即能破坏植物细胞的膜结构，引起原生质电解液外漏，导致细胞失水，同时还影响植物的运输机能，进而影响植物的结构，最终导致植物的死亡。

Under inhibit tumor fall increment andalert confession The objective of this experiment is to prove the antitumor effect and its mechanism in vivo of Erysimum cheiranthoides. In this study we observe the ratio of inhibitory of mice bearing S180 and the effect of prolonging lives of mice bearing H22;the effect on immune function of mice bearing S180;the phagocytosis of MO cells; measuring serum TNF of mice bearing S180 with ELISA; the expression level of p53 in tumor tissue with ICH and the change of tumor cells shape with pathology test.

实验采用S_(180)、H_(22)两种瘤株，以昆明利，小鼠为研究对象，对体内的抑瘤作用、生命延长作用进行研究；对S_(180)荷瘤小鼠免疫功能影响的研究；采用碳粒廓清法研究该药对巨噬细胞吞噬功能影响的研究；采用ELISA法检测S_(180)荷瘤小鼠外周血TNF含量；采用免疫组化法测定S_(180)小鼠瘤组织中p53蛋白的含量并观察瘤细胞的病理形态。

Its biological characteristic express two ways: increase wall of micrangium"s permeability and conjugate vascular endothelial cell"s specificreceptor, anxo-act vascular endothelial cell cleavage and proliferation, so lead to formate neogenetic vascular.

VEGF的生物学特性主要表现在两方面：增加微血管的通透性和特异性的与血管内皮细胞受体结合，促进血管内皮细胞的分裂和增殖，进而导致新生血管的生成。

Comparison from the Germany isolate, phocine distemper virus type Ⅱ(PDV-2) and vaccine strain, the major difference is the long signal peptide domain while the mature protein exhibit high identity, and all of the 13 serine residues, four potential asparagine glycosylation sites and two hydrophobic regions supposed to affect the fusion function are completely identical. These data supports the view that F protein is more conservative than H protein in CDV.

三、犬瘟热病毒中国分离株囊膜糖蛋白基因免疫小鼠诱发的抗体应答经一系列步骤将CDV-YZ0101株的两囊膜糖蛋白基因定向导入真核表达载体pcDNA3.1中，DNA测序和酶切分析筛选阳性重组质粒克隆pcDNA-H和pcDNA-F，以重组质粒DNA和脂质体共转染COS-7细胞，用间接免疫荧光试验证实转染的COS-7细胞的胞浆中分别表达了CDV的H和F蛋白。

Methods 16 adult female S-D mice with regular estrous cycles 4 days of were used in the experiment.Apigenin was fed by gavage to 8 mice in experimental group at doses of 10mg/100g.b.w in metestrus,and repurified water(2ml/mouse) were fed to 8 control rats.Two vaginal smears twice a day(8am,5pm)during on month, periodic variation of vagina epilhelial cell were observed for a whold month.

选取16只性周期规律（4日为一个性周期）的S-D雌性大鼠，随即分为两组，芹菜素灌胃组和三蒸水灌胃组，每组8只，于间情Ⅱ期给实验组大鼠用芹菜素（10mg/100g体重）一次性灌胃，对照组大鼠给三蒸水（2ml/只）灌胃，然后每日早晚两次做阴道涂片，连续一个月观测阴道上皮细胞的周期性变化。

The team found that there is a two-week window, or critical period, about a month after these new cells hatch during which they act like the neurons of a newborn baby. The researchers cued the new cells with a pattern of electrical activation that mimics the sequence that takes place in the brain of a mouse as it learns about a special spot (such as a corner in its cage where it may receive food or a shock).

该小组发现这些新细胞孵育期有两周的窗口期，或关键期，大约一个月后就孵育出新生的神经元，，因为获悉了一个特殊的位点（例如在大脑的某一角落是接受食物或惊吓的位点），研究人员开始模拟发生在老鼠脑细胞的新细胞的生长电活动的顺序模式。

We have no common name for a mime of Sophron or Xenarchus and a Socratic Conversation; and we should still be without one even if the imitation in the two instances were in trimeters or elegiacs or some other kind of verse--though it is the way with people to tack on 'poet' to the name of a metre, and talk of elegiac-poets and epic-poets, thinking that they call them poets not by reason of the imitative nature of their work, but indiscriminately by reason of the metre they write in.

索夫农 、森那库斯和苏格拉底式的对话采用的模仿没有一个公共的名称；三音步诗、挽歌体或其他类型的诗的模仿也没有——人们把&诗人&这一名词和格律名称结合到一起，称之为挽歌体诗人或者史诗诗人，他们被称为诗人，似乎只是因为遵守格律写作，而非他们作品的模仿本质。

The relationship between communicative competence and grammar teaching should be that of the ends and the means.

交际能力和语法的关系应该是目标与途径的关系。