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Objective To determine the correlation of the genotype and the phenotype for two novel mutations in phenyla lanine hydroxylase gene, and to study the expression of one of the mutated genes.

目的 观察新发现的两种苯丙氨酸羟化酶基因突变与临床表现型的关系,对其中一个位点进行基因表达的研究。

To be acquainted with the status of hepatitis B infection and abnormal rate of alanine transferase in general population in Dongguan.

了解东莞市体检人群中乙肝病毒感染情况与血清丙氨酸氨基转移酶的异常率。

Objective To be acquainted with the status of hepatitis B infection and abnormal rate of alanine transferase in general population in Dongguan.

摘 要]目的:了解东莞市体检人群中乙肝病毒感染情况与血清丙氨酸氨基转移酶的异常率。

Key Words:Population;Hepatitis B virus;Alanine transferase

关键词]人群;乙型肝炎病毒;丙氨酸氨基转移酶

By orthogonal experiment and diversity analysis, 1.0g/L zinc powder and 20g/L sodium glutamate added to conversion-solu...

通过正交实验和方差分析,确定在转化液中添加1.0g/L锌粉和20g/L谷氨酸钠作为效应物,L-苯丙氨酸积累浓度提高55%,该两种效应物对PAL的稳定性增加显著。

Objective To compare two methods of phenylketonuria screening for newborn.

目的 比较筛查新生儿苯丙酮尿症的2种检测苯丙氨酸的方法―细菌抑制法和荧光法。

And based on this principle,fluorescence detection system for neonatal phenylketonuria screening is designed.

如果在婴儿出生早期没有得到及时诊断和治疗,在发育过程中,高浓度的苯丙氨酸会严重损害婴儿的神经系统,将导致病儿不可逆的智力障碍,所以对其早期筛查尤为重要[1~3]。

Phenylalanine dehydrogenase (EC 1.4.1.20) is employed for the determination of Phenylketonuria in the clinic.

丙氨酸脱氢酶(Phenylalanine dehydrogenase,EC 1.4.1.20,简称PheDH)是临床苯丙酮尿症的检测用酶。

Hexokinse is inhibited by glucose 6-phosphate which builds up after PFKis inhibited.Pyruvate kinase is activated by fructose 1,6-bisphosphate but allosterically inhibited by ATP and alanine. Like PFK,it is also regulated hormonally by glucagon.

己糖既没被 PFK 受到抑制后积累的葡萄糖 6-磷酸激活,但受到 ATP 和丙氨酸的别构抑制;像 PFK 一样,它也受到胰高血糖素的调节。

MethodsHepatocyte injury model was induced by CCl4 and the injured hepatocytes were incubated with rat serum obtained after oral administration of CWC. The hepatocyte proliferation rate and alanine aminotransferase concentration in cell culture medium were determined. 446 patients with chronic hepatitis were divided into experimental group and control group treated by Hu Gan Tablets, HGT) randomly. With physical sign, symptom and hepatic function as main indices, the therapeutic effect of CWC on patients with chronic hepatitis was evaluated.

方法以SD大鼠为供体制备复方五仁醇胶囊含药血清,CCl4诱导大鼠原代培养肝细胞损伤模型,采用血清药理学方法考察含药血清对损伤肝细胞增值和培养上清液中丙氨酸氨基转移酶的影响;将446例慢性乙型肝炎患者随机分成治疗组和对照组,以临床症状、体征、肝功能为主要指标,考察复方五仁醇胶囊的治疗效果。

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