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丙氨酸

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Respectively, glutamic acid derivatized β-CD has been synthesized with epoxy chloropropane as the intermediate, a water-insoluble yellow liquid was got after the acetylating of the by using acetic anhydride, which was used as a novel gas chromatographic CSP; A water-soluble β-CD polymer cross-linked with epoxy chloropropane has been synthesized, and the derivatives of β-CD polymer were synthesized by its alkylating and acetylating. The different β-CD derivatives were coated on silica capillary columns by dynamic method, the chromatographic properties and retention behaviors of the fused silica capillary columns were studied, the results showed that the β-CD derivatives had good stereoselectivity and separation results to some compounds, especially to various positional isomers and enantiomers.

本文还分别以环氧氯丙烷为中间体,合成了七{2,6-二-O-[3-(1,3-二羟基丙氨酸)]}-β-环糊精,再用醋酸酐将其乙酰化,得到了一种淡黄色粘稠液体,合成了一种新型的环糊精衍生物;以环氧氯丙烷作交联剂合成了一种水溶性的β-环糊精聚合物,再将其烷基化和酰基化,合成了β-环糊精聚合物的不同衍生物,用动态法将不同类型的β-环糊精衍生物涂渍在石英毛细管柱上,通过对所制备柱柱性能的测试和对一系列化合物的分离和保留行为的研究,结果表明所合成的β-环糊精衍生物对各类化合物,特别是对位置异构体和对映异构体具有较好的分离效果,显示了很强的立体选择性。

In this thesis, the method of the synthesis of the common intermediate compoundof this style has been further studied. It is confirmed a procedure for esterifying the alanine.

本论文对该类化合物的常用中间体(1)的合成方法进行了改进性试验,避免了使用苄酯或叔丁基酯进行丙氨酸酯化,减少了反应的复杂性,简化了后处理方法。

MethodShengneng reagent and Shenneng control serum Ⅰ,Ⅱ(Lot NO.3229, Lot NO.4339) and patients' serum were used to evaluate the precision, linearity, accuracy and the schlepped polluting rate of 7180 biochemistry autoanalyzer by detecting these items as alanine aminotransferase, total protein, calcium, glucose, creatine Cre) and triglycerides.Hitachi 7600 autoanalyzer was used as the control analyzer to evaluate the correlation.

采用上海申能试剂,申能质控血清Ⅰ、Ⅱ(批号NO.3229,NO.4339)和病人血清,选定包括丙氨酸胺基转移酶、总蛋白、葡萄糖、钙、肌酐、甘油三酯在内的六个项目对7180进行精密度、线性、准确度及携带污染率的评价,并且与日立7600型生化仪进行相关性评价。

MethodShengneng reagent and Shenneng control serum Ⅰ,Ⅱ(Lot NO.3229, Lot NO.4339) and patients' serum were used to evaluate the precision, linearity, accuracy and the schlepped polluting rate of 7180 biochemistry autoanalyzer by detecting these items as alanine aminotransferase, total protein, calcium, glucose, creatine Cre) and triglycerides.

采用上海申能试剂,申能质控血清Ⅰ、Ⅱ(批号NO.3229,NO.4339)和病人血清,选定包括丙氨酸胺基转移酶、总蛋白、葡萄糖、钙、肌酐、甘油三酯在内的六

Human fibroblast interferon mRNA was prepared from poly I:C-cycloheximide superinduced human diploid cells by phenol-octanol exhaustion method followed by oligo-cellulose chromatography.

其主要实验根据是:超诱导细胞mRNA含量明显高于正常细胞;干扰素mRNA在非洲鲫鱼卵母细胞内转译的产物具有明显的抗病毒活性;转译时~14C-苯丙氨酸的掺入明显高于正常细胞;种属特异性实验及酶的敏感性实验证明转译产物中存在的抗病毒物质是一种人的干扰素蛋白质。

Her ALTs are three times normal.

她的丙氨酸转化酶指数超过了3倍

Phenylalanine – The main sources are carrots, beetroots, spinach, mint, tomatoes, pineapples and apples.

丙氨酸-的主要来源是胡萝卜, beetroots ,菠菜,薄荷,西红柿,菠萝和苹果。

Six and twelve boors after sepsis, leptin levels in liver homogenate were detected by radioimmunoassay serum alanine aminotransferase and 4 enzymes in liver homogenate. myeloperoxidase, glutathin-S-transferase, xanthine oxidase and superoxide dismutase, all related with synthesis of free radicals, detoxication and purine metabolism, were detected by 96 well spectrophotometry. H-E staining was used to examine the histopathologic changes of liver.

于脓毒症后6 h和12 h,采用放射免疫法测量肝组织匀浆液中Leptin水平,采用96孔分光光度法检测血清丙氨酸氨基转移酶及髓过氧化物酶、谷胱甘肽-S转移酶、黄嘌呤氧化酶、超氧化物歧化酶等4种与自由基合成、解毒和嘌呤生成代谢相关的酶的水平,同时以H-E染色法观察肝组织病理学改变。

Analysis of the relation between serotonin and its receptor in OFC and stress depression(n=8):(1) Microinjection of 5-HT into OFC significantly shortened immobility time, dejections have no great changes; though locomotor、 grooming activitives have little increased, they have no significant difference; rearing scores greatly reduced;(2)microinjection of pCPA into OFC significantly prolong immobility time, dejections have no great changes; locomotor、rearing activities are greatly reduced, but have no significant effect on grooming activity receding;(3)compared with the effect of 5-HT alone, microinjection of spiperone combined with 5-HT into OFC, significantly prolong immobility time and greatly reduced dejections; locomotor、 rearing、 grooming activities are all reduced, but have no significant differences.

眶额叶区5-羟色胺(5-hydroxytryptamine,5-HT)及其受体与应激性抑郁症的关系(n=8):(1)注射5-HT后,大鼠FST不动时间明显降低(P<0.05),粪便数量变化不显著(p>0.05),OFT水平运动、修饰得分虽均有升高,但无显著性差异(P>0.05),垂直活动显著降低(P<0.05);(2)注射色氨酸羟化酶抑制剂-对氯苯丙氨酸后,FST不动时间明显增加(P<0.01),粪便数量无显著性变化(p>0.05),OFT水平、垂直运动显著减少(P<0.05),修饰降低但无显著差异(P>0.05);(3)与5-HT组比较,先注射5-HT_(1A)受体拮抗剂后再注射5-HT,FST中的不动时间明显增加(P<0.01),粪便数量显著减少(p<0.01),但OFT水平、垂直、修饰活动均有所减少,却无显著性差异(P>0.05)。

This proved that the preparation and application of our Ag_2Cr_2O_7 dosimeters are successful; the measured values of absorbed doses are reliable and precise.3、 The dosage distribution of corresponding dosage measured points has been simulated by Monte Carlo method.

所得测量结果与中国计量科学研究院的丙氨酸/ESR剂量计间接比对的相对偏差为-3.0%,表明本论文制备的剂量计是成功的,剂量学性能是可靠的,对吸收剂量的测量结果也是准确的。

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