丙氨酰

Results: The proportion of Gram-negative bacilli rose obviously, so did the opportunistic pathogen's and Yeasts detected rate. Most drug sensitive tests showed the drug-fast rate turned to be high. Escherichia coli, Salmonella and Citrobacter resistant and so on to fluoroquinolones was 57%~97%. These bacteria to imipenem showed excellent activity. Meticillin-resistant-staphylococcus resistant to ciprofloxacin, norfloxacin, clindamycin, tetracycline, erythromycin, cefazolin and ampicillin were 40.9%, 42.4%, 63.6%, 72.2%, 85.9%, 100.0% and 100.0%, respectively Streptococcus and Enterococcus resistant to major β-lactams-penicillin, aminoglycosides, macrolides, tetracyclines and sulfonamides were between 36.0% to 100.0%.

结果：革兰阴性杆菌比例显著升高，条件致病菌和酵母样真菌检出机会显著增多；药敏结果显示多数临床细菌对常用抗生素的耐药趋势在不断上升；大肠埃希菌、沙门菌和枸橼酸杆菌等革兰阴性杆菌对喹诺酮类药物的耐药率达57%~97%，亚胺培南则对阴性杆菌有较高的敏感覆盖率；耐甲氧西林葡萄球菌对环丙沙星、诺氟沙星、氯洁霉素、四环素、红霉素、头孢唑啉和氨苄西林的耐药率分别为40.9%、42.4%、63.6%、70.2%、85.9%、100.0%和100.0%；链球菌和肠球菌对多数β内酰胺类青霉素、氨基糖苷类、大环内酯类、四环素类以及磺胺类药物均呈高度耐药，耐药率在36%~100%。

Methods Naloxone was synthesized starting from oxidation of thebaine, followed by hydrogenation, acylation, cyanidation, O-demethylation, hydrolyzation and N-allylation. The alternative method of O-demethylation, methane sulfonic acid/DL-methionine and hydrobromic acid were investigated.

在以蒂巴因为原料，经氧化、氢化、酰化、氰化、去氧甲基、水解、N-烯丙基化得到纳洛酮的合成路线中，分别采用甲磺酸／DL-甲硫氨酸和氢溴酸代替三溴化硼进行去氧甲基化和后续水解反应。

Methods Compound 3 was got via the formation of the amide from 2-chloro-3-amino-4-methyl pyridine and 2-chloronicotinoyl chloride, and then nevirapine was acquired by the aminolysis of 3 with cyclopropylamine in an autoclave, followed by the intramolecular nucleophilic substitution.

以2-氯－3-氨基－4-甲基吡啶为原料，依次与2-氯烟酰氯缩合成化合物3、再与环丙胺高压氨解、最后发生分子内亲核取代反应，成功合成了奈韦拉平。

Reactive oxygen species scavenger N-2-mercaptopropionyl glycine, protein kinase C antagonist chelerythrine, and mitochondrial KATP channel closer 5-hydroxydecanoate each blocked protection from 2 minutes of acidosis as they did for postconditioning.

活性氧簇清道夫N-2硫丙酰甘氨酸、蛋白激酶C拮抗剂白屈菜红碱、线粒体KATP通道关闭剂5-hydroxydecanoate都可以阻断两分钟的酸中毒和后条件的保护作用。

Positive and negative chronotropic responses were induced by application of isoproterenol and carbamylcholine, respectively.

应用异丙肾上腺素和氨甲酰胆碱可以分别诱导心肌细胞的正性和负性变时作用。

The propanedinitrile is synthesised from ethyl cyanoacetate by amination and elimination reaction.

由氰乙酸乙酯与氨反应生成氰乙酰胺，再经过消除反应制得丙二腈。

The alternative method of O-demethylation,methane sulfonic acid/DL-methionine and hydrobromic acid were investigated.

方法在以蒂巴因为原料，经氧化、氢化、酰化、氰化、去氧甲基、水解、N-烯丙基化得到纳洛酮的合成路线中，分别采用甲磺酸/DL-甲硫氨酸和氢溴酸代替三溴化硼进行去氧甲基化和后续水解反应。

A new fused polycyclic indoline compound was synthesized from aniline,with the key step of Pd-catalyzed tandem cyclization using hydroquinidine as the ligand and molecular oxygen as a green oxidant.

以芳香氨为原料，通过烯丙基化、重排、酰基化及钯催化的氧化环合反应合成了一种新的氮杂三环吲哚啉化合物，其结构经1H NMR，13C NMR，IR及HR-MS表征。

The hydrophobic core serves as a reservoir for water-insoluble drugs.Hence,these nanoparticles can be used as carriers for hydrophobic drugs.For the synthesis of cholesterol-modified glycol chitosan conjugates,a carboxyl group was initially introduced to cholesterol molecule using succinic anhydride,and then covalently coupled with the primary amino group of glycol chitosan in the presence of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride and N-hydroxyl succinimide.

本文采用二步反应将胆固醇接枝到乙二醇壳聚糖，首先将胆固醇进行羧基化，将胆固醇与琥珀酸酐反应生成胆固醇半琥珀酸酯，然后用1-乙基-3-(3-二甲基氨丙基)碳二亚胺盐酸盐与N-羟基琥珀酰亚胺作为偶联剂，将胆固醇半琥珀酸酯的羧基与乙二醇壳聚糖主链的氨基进行反应，得到胆固醇疏水改性乙二醇壳聚糖共聚物。

Three activated carbons having different surface areas, coconut-shell based, pelletized and bamboo-derived, were modified by mixing them with four thermoplastic precursors, poly, hydroxy propyl cellulose, citric acid, and fluorine-containing polyimide followed by heat treatment at 900℃ for 1h.

三种具有不同比表面积的活性炭—椰壳基AC-C、粒状AC-P和竹基AC-B分别与四种热塑性前驱体—聚乙烯醇，羟基丙基纤维素，柠檬酸，含氟聚酰亚氨混合后，在900℃热处理1h。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了