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丙氨酰

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Nine seasickness adaptive proteins were identified by PMF: peroxiredoxinⅠ, peroxiredoxinⅡ, light molecular-weight neurofilament, ubiquitin carboxyl-terminal hydrolase PGP9.5, and glutamine synthetase were highly expressed; carbonic anhydraseⅡ, triosephosphate isomeraseⅠ, phosphoglycerate mutase isozyme B and mitochondrial voltage dependent anion channel were lowly expressed.

获得了9个晕船适应相关蛋白质:硫氧还蛋白过氧化物酶Ⅰ、硫氧还蛋白过氧化物酶Ⅱ、低分子量神经丝蛋白、泛素羧基末端水解酶PGP9.5和谷氨酰胺合成酶上调;碳酸酐酶Ⅱ、磷酸丙糖异构酶Ⅰ、磷酸甘油酸变位酶B和线粒体电压依赖型阴离子通道下调。

The synthesis of the pentacyclic skeleton of Et-743 and the construction of the five chiral centers thereof.1. The core pentacyclic skeleton of phthalascidin was constructed with L-dopa as the starting material via thirteen steps. First, two basic synthons, the C-1 functionalized tetrahydroisoquinoline compounds 8 and N-protected Z-dopa derivative 9, were prepared from L-dopa. They were coupled via amide bond to form the dipeptide compounds 10, which were the first key intermediates. Then the primary hydroxyl groups were transformed into the corresponding amino aldehydes 11 via Swern oxidation. Followed by the intramolecular Pictet-Spengler cyclization, the pentacyclic compounds 12 were synthesized.

五环骨架的构建及五个正确手性中心的确立:1.1我们以L-多巴为起始原料,经过多步官能团保护和转化合成了基本结构单元8然后和苯丙氨酸衍生物9,通过缩合反应生成酰胺中间体10,经Swern氧化得到醛化合物11,然后再次利用分子内改良的Pictet-Spengler反应一步构建c,d两环,得到五环骨架化合物12,最后,实现了21-位羰基向氰基的转化,得到了C-1位官能化的化合物14,化合物14不但具有和Et-743一致的五环骨架,而且分子中五个手性中心立体构型也与其完全相同:其中,3,位和13,位的手性中心由原料L-多巴带入,而1,位,11,位和21,位手性中心则通过不对称诱导而确立。

Four new chiral sulfonamide alcohol s were synthesized from camphor and L-phenylalanine and their application to the enantioselective addition of diethylzinc to benzaldehyde was described.

由天然樟脑和-苯丙氨酸合成了4个新的手性磺酰胺醇,并对其在二乙基锌对苯甲醛的不对称加成中的催化性能进行了研究。

Four new chiral sulfonamide alcohols were synthesized from camphor and L-phenylalanine and their application to the enantioselective addition of diethylzinc to benzaldehyde was described.

由天然樟脑和-苯丙氨酸合成了4个新的手性磺酰胺醇,并对其在二乙基锌对苯甲醛的不对称加成中的催化性能进行了研究。

To the most suitable nitrogen source for the growth of black spot disease of Araliaceae was the complete protein peptone which was stronger than comparison, glutanic acid, asparagine,alanin, potassium nitrate, nitrate of soda, ammonium sulfate, ammonia water, ammonium chloride.

对刺五加黑斑病菌最适合生长的氮源为完全蛋白胨强于对照,强于谷氨酸,强于天门冬酰胺,强于丙氨酸,强于硝酸钾,强于硝酸钠,强于硫酸铵,强于氨水,强于氯化铵。

The results showed that precursor feeding (phenylanine, sodium acetate and benzamide) and mixed sugar as production medium resulted in significant increase of taxol production not only in the one-liquid-phase cultures of Taxus chinensis var. mairei but also in the two-liquid-phase cultures. And the integrated function of precursor feeding and mixed sugar in the two-liquid-phase cultures gave more significant increase of taxol production significant increase of taxol production, which was four times more than that of the control (the one-liquid-phase culture without precursors and mixed sugar).

结果表明前体饲喂(苯丙氨酸,醋酸钠和苯甲酰胺)和蔗糖与麦芽糖配伍作为生产培养基糖源不仅对红豆杉细胞悬浮培养,而且对其两液相培养的紫杉醇产量提高均有明显的促进作用,与对照组相比,在南方红豆杉细胞两液相培养中,采用前体饲喂和蔗糖与麦芽糖配伍作为生产培养基糖源,紫杉醇产量提高4倍多。

The formation of charge transfer complex was studied in the first part. The second part includes the synthesis and characterization of the acrylated unsaturated polyester and the kinetic studies on the Ar-UPE/ triethylene divinyl ether (DVE-3) photocuring system, the rheology and properties of film after photocuring. The third part includes the synthesis and characterization of the urethane modified unsaturated polyester and the kinetic studies on the PU-UPE/DVE-3 photocuring system, the rheology and properties of film after photocuring. The fourth part includes the synthesis and characterization of the vinyl ether end capped polyurethane and the kinetic studies on the VE-PU/DVE3 photocuring system, the rheology and properties of film after photocuring.

整个研究工作分为四个部分:一是电荷转移复合物的研究;二是丙烯酰氧基化不饱和聚酯的合成,表征,Ar-UPE/二缩乙二醇二乙烯基醚(DVE-3)体系光固化动力学研究以及Ar-UPE/DVE-3体系流变性能和光固化后涂膜综合性能的研究;三是氨酯改性的不饱和聚酯的合成,表征,PU-UPE/DVE-3体系光固化动力学研究以及该体系光固化后涂膜综合性能的研究;四是乙烯基醚封端的聚氨酯的合成,表征,VE-PU/马来酸二甲酯体系光固化动力学研究以及VE-PU/DMA体系流变性能和光固化后涂膜综合性能的研究。

A series of novel low molecular weight gelators based on L-alanine group have been obtained. The amphiphiles, 1-3, can gelate many organic solvents with low polarity. The structures of the organogel formed by 1-3 have been 〓 studied by TEM, DSC, XRD and FTIR techniques.

TEM、DSC、XRD和FTIR等方法对这些两亲物形成的有机胶凝聚集体结构表征表明,这类小分子胶凝剂在有机溶剂中形成了反双分子膜,其中N-酰代〓L-丙氨酸和适当长度碳氢尾链(9-13个碳原子)是其胶凝性能必须的结构单元。

It showed that the application of 5′-NT in acute hepatitis, live cancer and osteal diseases were significantly higher than that of controls.

用法国Biomerieux公司(5′-NT)诊断试剂盒测定血清5′-NT酶活性,同时测定患者血清谷丙转氨酶和γ-谷氨酰转肽酶,碱性磷酸酶酶活性的变化。

Serially observed the serum active enzymatic of 5′-NT changing in process of hepatic diseases might be a biological prognostic marker, together with ALT,γ-GGT and ALP, it can be used to distinguish and diagnose most hepatic and osteal diseases.

2联合检测血清5′-核苷酸酶(5′-NT),谷丙转氨酶和γ-谷氨酰转肽酶,碱性磷酸酶酶活性的检测有助于鉴别诊断肝脏疾病、胆道疾病和骨骼疾病。

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