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丙氨酰

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It is broken down via phenylalanine to give acetyl CoA and fumaric acid.

它通过苯丙氨酸降解出乙酰辅酶 A 和反丁烯二酸。

Photo-induced grafting polymerization of acrylamide onto polyetherurethane was studied with benzophenone as sensitizer under irradiation of 365 nm.

本文研究了以二苯酮为光敏剂,在365nm光照下丙烯酰胺在聚醚氨酯表面的接枝聚合。

To detect the marks reflecting the liver functions as follows:①The marks to reflect the capability to synthesize proteins, TPROT, ALB, GLB;②The marks to reflect the injury of the liver cells: AST, ALT, CHE;③The marks to reflect the capability to egest the bile, excrect, and detoxicate: TBILI, DBILI, IBILI, TBA;④The enzymes to reflect the cholestasis: GGT, ALP. Results The results of both the morphological and the pathological studies showed that the degree of the liver cirrhosis was of the terminal stage.

肝功能指标:①反映肝细胞蛋白合成代谢功能的指标:总蛋白TPROT,白蛋白ALB,球蛋白GLB;②肝细胞受损的指标;谷草转氨酶AST,谷丙转氨酶ALT,胆碱脂酶CHE;③反映肝脏胆排泄、分泌及解毒功能的指标:总胆红素TBILI,直接胆红素DBILI,间接胆红素IBILI,总胆汁酸TBA;④胆汁淤积指示酶:谷氨酰转肽酶GGT,碱性磷酸酶ALP。

Methods the all cells were divided into four groups: control group, p-tosyl-l-phenylalanine chloromethyl ketone group, dexamethasone group, cotreatment group.

分组:对照组、对甲苯磺酰-l-苯丙氨酸甲基甲酮组、地塞米松组、tpck+dex组。mtt比色分析法测定细胞生长抑制率,流式细胞术测定细胞凋亡率。

The result of uroscopy of the proband was strong positive. There was a novel deletion mutation of c.876-877 del TC in the coding region of exon 6 of IDS gene, which was a hemizygous mutation. However, the mutation of his mother and sister was a heterozygous mutation. Detection of the exon 6 of IDS gene showed that the mutation was not found among normal controls and other patients with MPS I, IV, and VI other than MPS II. Homology comparison of amino acid sequences from different species showed that the phenylalanine glutamine of the mutation site of c.876-877 del TC located in p.292-293 was highly conserved. The activity of IDS enzyme of the proband was only 2.3 nmol/4 h/mL, which was much lower than normal; but the activity of IDS enzyme of his father, mother and sister was 641.9 nmol/4 h/mL, 95.8 nmol/4h/mL and 103.2 nmol/4h/mL, respectively.

结果显示:先证者尿检呈强阳性;其IDS基因exon 6编码区内存在c.876-877 del TC新缺失突变,为半合子突变,而其母、其姐为杂合突变;正常对照和其他非II型MPS患者的IDS基因exon 6的检测结果均未发现该突变;不同物种氨基酸序列的同源性比对显示: c.876-877 del TC突变所在的位置即p.292-293的苯丙氨酸谷氨酰胺高度保守;酶活性测定的结果显示:先证者的IDS酶活性仅为2.3 nmol/4 h/mL,大大低于正常值,而其父的为641.9 nmol/4 h/mL,其母的血浆酶活性为95.8 nmol/ 4h/mL,其姐的为103.2 nmol/4 h/mL。

(1)PAL is better entrapped by PAG with a T∶C ratio of 8∶30.(2)PAL immobilized by glutaric dialdehyde on Bio-Gel P-300 is better than by CDC.(3)The best one is the dehydration and redehydration method.(4)Immobilized and permeated PAL active yeast cells are resistant to trypsin digestion and retain its PAL activity.

(1)固定化酶活性采用T∶C比为8∶30明显高于8∶19;(2)以戊二醛将PAL固定于Bio-GelP300优于用DCD固定化的酶;(3)质脂体包被中以脱水再加水法对酶活性影响较少,脂类组成以磷脂酰胆碱:胆固醇:磷脂酰丝氨酸比值7∶2∶1最好;(4)固定化PAL活性酵母细胞能较好地抵抗人工肠液中胰蛋白酶的水解作用,亦能明显降低苯丙氨酸的浓度。

The changes of peroxidase and phenylalanine ammonia lyase in several jujube cultivars inoculated with phytoplasmas were analyzed by using spectrophotometer and incontinuous polyacrymide electrophoretic methods.

采用分光光度计和不连续聚丙烯酰胺凝胶电泳,比较分析了不同枣树品种及株系接入病原植原体后,其过氧化物酶及同工酶和苯丙氨酸解氨酶的变化。

Pharmacodynamics experiments indicated that the drug obviously degraded the content of Cholesterol,Triglycerides,glutamic pyruvic transaminase and Maleic Dialdehyde in the Alcoholic fatty liver of rats and mice treated with by oral administration, it also degraded the content of glutamic oxalacetic transaminase, r-GLU,alkaline phosphatase and increased the content of Albumin and Superoxide Dismutase in the Alcoholic fatty liver of rats, and remarkably reduced depressant effect of the mice'centra nerve.

药效学实验表明,经预防灌胃给药,可以显著降低酒精性脂肪肝大鼠和小鼠,总胆固醇、甘油三酯、谷丙转氨酶、丙二醛含量,降低酒精性脂肪肝大鼠谷草转氨酶、γ-谷氨酰基转移酶、碱性磷酸酶含量,增加白蛋白和超氧化物歧化酶含量。

Respectively, glutamic acid derivatized β-CD has been synthesized with epoxy chloropropane as the intermediate, a water-insoluble yellow liquid was got after the acetylating of the by using acetic anhydride, which was used as a novel gas chromatographic CSP; A water-soluble β-CD polymer cross-linked with epoxy chloropropane has been synthesized, and the derivatives of β-CD polymer were synthesized by its alkylating and acetylating. The different β-CD derivatives were coated on silica capillary columns by dynamic method, the chromatographic properties and retention behaviors of the fused silica capillary columns were studied, the results showed that the β-CD derivatives had good stereoselectivity and separation results to some compounds, especially to various positional isomers and enantiomers.

本文还分别以环氧氯丙烷为中间体,合成了七{2,6-二-O-[3-(1,3-二羟基丙氨酸)]}-β-环糊精,再用醋酸酐将其乙酰化,得到了一种淡黄色粘稠液体,合成了一种新型的环糊精衍生物;以环氧氯丙烷作交联剂合成了一种水溶性的β-环糊精聚合物,再将其烷基化和酰基化,合成了β-环糊精聚合物的不同衍生物,用动态法将不同类型的β-环糊精衍生物涂渍在石英毛细管柱上,通过对所制备柱柱性能的测试和对一系列化合物的分离和保留行为的研究,结果表明所合成的β-环糊精衍生物对各类化合物,特别是对位置异构体和对映异构体具有较好的分离效果,显示了很强的立体选择性。

In the first part, a high performance anionexchange chromatography for simultaneous determination of four artificial sweeteners (sodium saccharin, aspartame, sodium cyclamate and acesulfame-K) and citric acid was proposed.

第一部分提出了一种采用高效阴离子交换色谱法同时测定四种人工合成甜味剂(糖精钠、天门冬酰苯丙氨酸甲酯、环己基氨基磺酸钠、乙酰磺胺酸钾)和柠檬酸的新方法。

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