丙二醇

Then Doripenem came into the market in the July ,2005. We studied the synthesis of Doripemen.Firstly, we synthesized the chemical 2 from the starting material------o-hydroxylphenylacylamine through Reformastky reaction, alkylation, Diekmann reaction, enolization, esterification and etc. Secondly, we synthesized the chemical 3 from L — hydroxylproline through the protection of carboxyl, amidogen and hydroxyl group, reduction by NaBr, SN_2 substitution and Mitsumobu reaction.

我们以水杨酰胺为起始原料，经Reformatsky反应、烷基化、Diekmann环合、烯醇化、酯化等反应合成双环母核2；再从L-羟基脯氨酸出发，经酯化保护羧基、保护氨基、保护羟基、硼氢化还原酯得醇、Sn2取代和Mitsumobu反应等合成巯基侧链3；最后由化合物3经脱保护、水解得硫醇，和化合物2在二异丙基乙基胺的作用下缩合，最后Pd／C催化脱保护，历经16步反应最终得到产物多尼培南。

The results showed that there were 8 kinds of aliphatic, 5 kinds of esters, 2 kinds of aldehydes, 2 kinds of nitrogen sulfur heterocyclic rings and one kind of hydrocarbon, alcoholics, ketone, lactones respectively in the analyzed 21 kinds of aroma components, and the content of furfural,β-methyl valeric acid, palmitic acid, nicotine, neohytadiene were higher, next were acetyl ethyl propionate, caleric acid, phenyl ethyl acetate, hydroxylic diethyl succinate.

结果表明，在分析出的21种香气成分中，分别有脂肪酸类8种，酯类5种，醛类2种，氮硫杂环类2种，烃类、醇类、酮类、内酯类各l种，其中相对含量较高的物质成分是糠醛、β-甲基戊酸、十六碳酸、烟碱、新植二烯，其次是乙酰丙酸乙酯、异戊酸、苯乙酸乙酯、羟基丁二酸二乙酯等。

The results showed in the seven food preservative s,that calcium propionate had no effect on the growth of Peronophythoral litchii,while cinnamyl glyceroyl fumarate was the best.

结果表明：在所用的7种食品防腐剂中，丙酸钙对荔枝霜疫霉菌的生长无抑制作用，反丁烯二酸桂醇甘醇酯的抑菌效果最好

With toluene two isocyanogen diethylene glycol dinitrate, the polyester or the polyether dihydroxy alcohol, two methylol propionic acid, the triethylamine, the ethylene diamine and so on are raw materials, uses the prepolymer dispersion method, has prepared a series of anion river character polyurethane emulsion.

用甲苯二异氰酸酯、聚酯或聚醚二元醇、二羟甲基丙酸、三乙胺、乙二胺等为原料，采用预聚物分散法，制备了一系列的阴离子水性聚氨酯乳液。

A series of secondary pollutants with small molecule are produced from these reagents,such as ethanol,aldehyde,acetone,acetonitrile,propionitrile,isobutanol...

药剂在降解的过程中会产生乙醇、乙醛、丙酮、乙腈、丙腈、异丁醇、戊醇等一系列小分子二次污染物。

Two kinds of new intermolecular complex antioxidants 3-(3, 5-di-butyl-4-hydroxyphenyl) propionyl pentaerythritol phosphate and octstearic pentaerythritol tetra- phosphite were synthesized by one-pot and two steps transesterification.

分别采用一锅法和两步酯交换法合成了两种新型分子内复合型抗氧剂，即3-(3，5-二叔丁基-4-羟基苯基)丙酰亚磷酸季戊四醇酯和八硬脂基季戊四醇四亚磷酸酯。

Ingredients:Rose extract, whitening factor, dimethyl siloxane, tetradecanoic acidisopropyl, cetearyl alcohol, rrimethylglycine, glycerol, xanthane, bisabolol.

成分：玫瑰提取液，美白因子，二甲基硅氧烷，肉豆蔻酸异丙酯，十六十八混合醇，三甲基甘氨酸，甘油，汉生胶，红没药醇。

Ingredients:olive extract,whitening factor,dimethyl siloxane, tetradecanoic acidisopropyl, cetearyl alcohol, rrimethylglycine, glycerol, xanthane, bisabolol.

成分：橄榄提取液，美白因子，二甲基硅氧烷，肉豆蔻酸异丙酯，十六十八混合醇，三甲基甘氨酸，甘油，汉生胶，红没药醇。

As CAAX-mimetics, 1, 3-dihydro-5-phenyl-2-H-1, 4-benzodiazepin-2-one was modified by linking carboxyl groups with various carbon through N-1 and C-3, 3-(imidazol-4-yl) propion amido group with different substituents was connected at C-7; In the synthesis of bisubstrate analogues, thiocarbamido compounds was alkylated by alkyl iodide and then hydrolyzed to give alkylthiol benzoate compounds.

1，4-苯并二氮杂草-2-酮类化合物的合成过程中分别对其1、3、4和7位进行了基团变化，在1和3位连接不同长度含羧基或酯基的侧链，在7位连接不同取代的咪唑丙酰氨基。在苯甲酸硫醇酯化合物合成过程中，建立了一种硫原子连有不同长度碳链的苯甲酸硫醇酯的合成方法。

Cellulose, mannitol, hydroxypropyl methylcellulose phthalate, citric acid, sodium starch glycolate, glyceryl triacetate, modified cellulose gum, stearic acid, colloidal silicon dioxide, titanium dioxide and yellow ochre.

纤维素，甘露醇，羟丙基甲基纤维素邻苯二甲酸酯，柠檬酸，淀粉钠乙醇，三醋酸甘油酯，改性纤维素胶，硬脂酸，胶质二氧化矽，二氧化钛和黄赭色。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。