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TGF-βbinds to a heteromeric complex of type I and type II receptors. The constitutively active type II receptor phosphorylates and activates the type I receptor which phosphorylates Smad2 and Smad3 (receptor-associated Smads). Receptor-associated Smads bind the common mediator Smad4 and are translocated to the nucleus, where they associate with DNA-binding cofactors to modulategene transcription.

TGF-β与其效应细胞表面的Ⅱ型受体TβRⅡ和Ⅰ型受体TβRⅠ形成的异源二聚体结合,相继激活TβRⅡ和TβRⅠ,活化的TβRⅠ再进一步活化Smad2和Smad3,磷酸化的Smad2/3必须与Smad4结合形成复合物,才能进入细胞核,调节靶基因的转录[6]。

In black soil and meadow soil, the aliphatic structure of humin linked to iron and humin linked to clay are stronger than humic acid and fulvic acid.

结果表明:铁结合胡敏素、粘粒结合胡敏素与胡敏酸、富里酸具有相似的光谱特征,但存在明显差异。

The results in this paper are concluded as follows:(1) Rolling contact fatigue has been used to examine the interfacial reaction products and study the mechanism of ion beam intermixing effect on the adhesion of Cr-N coating on steel by IBAD.

对多次冲击条件下薄膜的失效抗力及其与薄膜力学性能之间的关系进行了初步探讨,得到如下结果:(1)用滚动接触疲劳法检测离子轰击导致的界面反应产物和研究离子束共混对钢基体上IBAD沉积Cr-N薄膜结合强度的影响本质,结果表明,滚动接触疲劳能有效地分析界面最薄弱位置和评估界面反应产物,滚动接触疲劳引起的剥落可作为研究界面反应产物对结合强度影响的根据。

On data management, this paper uses Geodatabase and ArcSDE to manage graphic and attribute of spatial data, which can implement seamless integration and incorporable management. ArcSDE joins the distributed spatial and attribute data, so the users can maintain higher storage and data integrity.

在国土资源数据管理方面,ArcSDE与Geodatabase结合,实现了空间数据的图形和属性的无缝集成和一体化管理,把目前分别存储的空间数据和属性数据结合起来,从而保证了更高的存储效率和数据完整性。

Compressive strength curing 7 days of lime-polishing powder binder is slightly higher than those of lime-fly ash binder, but amplitude of strength curing 28 days is obvious high, average amplitude is up to 190% and maximal amplitude is up to 210% comparing to fly ash-lime binder. Lime-PP binder preceded lime-FA binder in intenerate index of 7 days and 28 days under the same ratio of PP to lime condition.

结果表明:在相同配比条件下,石灰-抛光砖粉结合料与石灰-粉煤灰结合料相比,前者的早期抗压强度略有提高,28d抗压强度增幅明显,平均增幅达190%,最大增幅高达210%;前者的7d、28d软化系数均高于后者,具有更好的水稳定性。

NodD was demonstrated to bind to nod promoters in isologous octamer and induce bending of target DNA while binding.

我们发现NodD以八聚体形式结合DNA,它与DNA结合时诱导DNA弯折。

To develop standard WNV diagnostic tools, four monoclonal antibodies against WNV envelope protein domain III were produced. The isotype, the reactivity with denatured and native antigens, the affinity and specificity of antibodies have been characterized. Two MAbs (4B3 and 2F5) were used to establish an antigen capture-ELISA detection system.

为了建立有效的WNV检测方法,本研究制备了四株抗WNV囊膜蛋白第三结构域的单克隆抗体,鉴定了抗体的亚型、抗体和变性及非变性抗原结合的强度、抗原和抗体结合的亲和力常数,进行了免疫荧光分析、测定了抗原表位竞争、抗体的中和能力等,并检测了上述单抗与日本乙型脑炎病毒的交叉反应情况。

The main quenching mechanism of fluorescence of LYSO by kaempferol was a dynamic quenching.

计算得出了25℃时,山奈酚与溶菌酶间的结合常数和结合位点数分别为6.86×10^3molL^(-1)和0.90。

Studies of the binding of metal to calmodulin and the subsequent binding of metal-calmodulin complexes to the target protein/peptide revealed that the La-content calmodulin complexes to its target exhibit similar affinity with the Ca-calmodulin complexes.However, there were substle differences in protein conformation as well as the kinetical properties between the two kinds of metal-calmodulin complexes, suggesting Ln could produce cellular effects via the Ca/calmodulin signaling systems.

稀土离子和钙调蛋白的结合以及后续和靶酶的结合,在热力学上与钙离子激活蛋白具有相同的亲合力,但在动力学性质上以及细微构象上明显不同,显示稀土离子可通过细胞钙相关信号系统产生特别的生物效应。

Eleven subcloned DNA fragments from the 5′- upstream region of lipA, lipC and lipF of Phanerochaete chrysosporium were assayed by using the gel mobility shift assay. The total proteins extracted from P.chrysosporium mycelia grown in Kirk medium and natural fir wood chip were used to identify the segments in these 11 DNA fragments which are controlled by some regulatory proteins.

用DNA-蛋白质体外结合实验和凝胶迁移率变动分析技术筛选黄孢原毛平革菌木质素过氧化物酶基因lipA、lipC、lipF的5′-端调控区内能与该菌在木质素降解条件下形成的蛋白特异结合的顺式作用元件。

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This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。

There is no differences of cell proliferation vitality between labeled and unlabeled NSCs.

双标记神经干细胞的增殖、分化活力与未标记神经干细胞相比无改变。