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"Despite confounding factors, such as concomitant medications which have been associated with skin reactions, several cases reported to described a plausible temporal relationship, positive dechallenge, and/or positive rechallenge supporting an association between infliximab and serious cutaneous skin reactions," the newsletter notes.

这篇安全新闻结论指出,一如蛋白质产品,这3种TNF-alpha拮抗剂潜在致免疫性,且会促使免疫调节严重皮肤反应,如EM、SJS和/或TEN;评估TNF-alpha拮抗剂和严重皮肤反应之间的关联,可能会因为一些共同因子而造成挑战,例如同时服用的1种或多种药物与EM、SJS和/或TEN的关联,当接受TNF-alpha拮抗剂治疗时发生任何的严重皮肤反应须有适当的诊断和治疗,以及考量替代治疗。

Because reinfestation after treatment is an indicator of poor sanitation, correction of sanitary deficiencies is likely to abate the parasite problem and other, more serious diseases.

这是因为寄生虫的蔓延与不良卫生环境有关,而改善卫生状况有助于缓解寄生虫问题,同时也有利于减少其它严重疾病的发生。

The change of landuse patterns in 1977-1998 shows indirectly the desertified land had been restored and is being restored. The relationship between landuse patterns and soil types was also analysed in this paper, from 1977 to 1998, the areas of rangeland and mobile sand dunes decreased in most soil types and the areas of woodland, shrubland and farmland increased, which means that the modification of landuse patterns due to limitation of soil types will be helpful to desertification control.

同时土地利用格局的时空变化与土壤类型间关系的分析表明,1977-1998的20余年间,在四种主要土壤类型上各种土地利用类型的变化具有一定的规律性,草牧场和流动沙地的面积基本上呈减小的趋势(分布在风沙土上的草牧场面积除外),而乔木林地,灌木林地和农地面积均为增加的趋势,这说明在土壤类型这一土地自然属性的严重制约下,人们被迫调整其土地利用格局,从而有效地遏制了荒漠化的发生和发展。

Clashes between Lazio fans and police began just arrived at Termini station of Rome while the fans were trying to get on the train.

拉齐奥的球迷在罗马中央火车站尝试挤进列车的同时,他们与警方的冲突发生了。

The nano-silica partrcles are organic-modified by E-MA-GMA elastomer through direct solvent process,the organic-modify process mechanism was studied,and the dispersing of modified nano-silica particles in tetrachloroethane solvent and PBT were investigated.FIRT,TEM,SEM results indicated that the epoxy group of E-MA-GMA could react with the hydroxyl groups of silica surface,helped to reduce the interactions of nano-silica particles particles and improve the dispersion of nano-silica on PBT and the interfacia...

surface modification ;溶液法利用功能化弹性体E-MA-GMA对纳米二氧化硅进行表面有机化修饰改性,分析了表面改性过程机理,同时考察了改性后纳米二氧化硅在四氯乙烷溶剂和PBT基体中的分散情况;FIRT、TEM、SEM测试结果表明,E-MA-GMA的环氧基团与纳米SiO_2的—OH基团发生反应,降低纳米二氧化硅粒子间的相互作用力,改善了纳米二氧化硅在PBT基体中的分散,提高复合材料的相容性。

Reactive oxygen species causing DNA oxidative damage comes from two kinds of ways:one is from cellular normal physiological metabolism;the other is from outer environment.Redox-sensitive green fluorescent protein was expressed in Saccharomyces cerevisiae.Recombinant cells were evaluated in monitoring the changes in the redox state of living cells when challenged with toxicologically relevant metal ions NaAsO_2 or Pb(NO_3)_2 by measuring emission intensity at 510 nm with a Hitachi F6500 fluorescence spectrophotometer,roGFP expressed in yeast responded not only to typical membrane-permeant oxidants H_2O_2 and reductants DTT,but also to toxicological metal ion-induced intracellular redox changes in a dose-dependent manner.Moreover,exposure of yeast cells to NaAsO_2 or Pb(NO_3)_2 at concentrations that induced redox changes reported by roGFP caused up to 2~3 fold increases in DNA mutation frequency.This mutagenic effect was largely caused by oxidative stress since blocking the production of hydryl radicals with thiourea significantly reduced the mutation rate as well as delayed the cell death.

本文将对氧化还原状态变化敏感的绿色荧光蛋白roGFP1-R12,在酵母细胞中实现了多拷贝强表达;荧光扫描经强氧化剂H_2O_2和还原剂DTT以及环境中重金属NaAsO_2或Pb(NO_3)_2处理后的酵母细胞悬液,测定510 nm处的荧光发射强度结果显示,表达的绿色荧光蛋白对氧化还原水平敏感,且在510 nm处的荧光强度与一定的重金属浓度呈正相关,即roGFP1-R12在510nm处的荧光发射值随重金属浓度的增高而增强,从而说明重金属对细胞的毒性在一定程度上很可能是通过破坏细胞内的氧化还原平衡发生作用;同时通过该绿色荧光蛋白对胞内氧化还原状态变化的响应情况可以来实时检测环境中的重金属;遗传学的点突变频率及致死率实验数据表明,重金属能导致菌体的点突变频率和致死率升高,且活性氧的清除剂巯基脲能明显降低这种点突变和致死率,说明由重金属引发的这种点突变和致死效应在很大程度上是依赖于重金属对细胞诱导产生的氧化胁迫。

After getting it, we can analyse and acquire the criteria of wind speed according to uncomfort data of questionnaires. The emphases of analyse comprise both wind velocity and probability.

在得到阵风因子的值之后,便可根据问卷中不舒适的资料分析出风速标准,而分析的重点同时包含风速大小与发生机率。

This paper was mainly working on the biochemical changes (water, carbohydrate, lipid, fatty acid, protein, amino acid) during embryonic development of Cherax quadricarinatus. At the same time, we especially worked on the yolk protein-vitellin in two aspects: 1. Isolation, purification and characterization of vitellin from the ovary of female Cherax quadricarinatus.

本文对红螯螯虾胚胎发育过程中的主要生化物质(水分、碳水化合物、脂类、脂肪酸、蛋白质、氨基酸)进行了测定,特别是对胚胎发育过程中主要的营养物质——卵黄磷蛋白的结构和含量变化做了细致的研究,同时讨论了这些物质的变化与红螯螯虾胚胎发育形态发生的相关性。

Competition and co-ordinary will take place both in country market and international market, which means that the real globalization competition era is befalling on our corporation, so that the meaning of corporation international operation has been changed.

竞争与合作将在国内和国际市场上同时展开,这意味着我国企业全球竞争时代的真正来临,因此,我国企业国际化经营的内涵也发生了重大转变。

It is endlessly building, deforming and reestablishing.

日常的事物是循环性发生和互相渗透的,它同时存在于每一件事物的开始和终结,而且它也无休止的在建立,变形与重建。

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As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸,那乌黑、忧郁的眼睛,她便会相信,他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失

But because of its youthful corporate culture—most people are hustled out of the door in their mid-40s—it had no one to send.

但是因为该公司年轻的企业文化——大多数员工在40来岁的时候都被请出公司——一时间没有好的人选。