不能破坏的

One hand mechanical obstruct led to the increase of veinous resistance and the obstacle of microcirculation, the other hand the adhesive PMN was activated in excess, the white blood cells released a lot of enzymes, in which PMN-elastase can decompose the components of cell and many albumens, inclusive of immunoglobulin、alexin and fibrication. These components induced the injury of the pancreatic capillary vessels and cell and lysosome enzy made the tissue protein hydrolyze and produced unsaturated fatty acids, which destroyed the structure and function of cellar membrane. The inflammatory cellar factors activate other immunocytes to produce the injury and necrosis of tissue, which aggravated the pathological injury and led to shock、pyaemia and MODS. So ICAM-1 and LFA-1 played an important role in SAP. Frossard found that the expression of ICAM-1 in the rat model, especially in serum、pancreas and lung. All these showed ICAM-1 is an important factor in AP and concomitant lung injury.

胰腺小叶组织局部血管EC首先被激活，ICAM-1表达升高，与被激活的PMN表面表达的LFA-1相结合，"PMN-EC"相互作用加剧，一方面机械性阻塞毛细血管导致静脉阻力增加、微循环障碍；另一方面粘附的PMN过度吞噬或激活，当白细胞吞噬的颗粒不能被封闭隔离，连同细胞内的酶被释放出来，其中的PMN-elastase能够降解细胞基质中各种成分，水解多种蛋白，加重胰腺的毛细血管内皮细胞和腺泡的损伤；释放的溶酶体酶使组织蛋白水解，产生的不饱和脂肪酸引发脂质过氧化方应，破坏细胞膜的结构和功能；释放的炎性细胞因子，激发其他的免疫细胞的功能，导致进一步的组织损伤和坏死，加重SAP的病理损伤，最终导致休克、脓毒血症及多器官功能障碍等严重后果。

An index is calculated as the ratio of the economic loss estimated by using the continuity method and the economic loss calculated by using the discrete method with different seismic performance levels.The minimum number of performance levels is considered as the rational result when the index is within a prescribed small range.

这在1994年美国北岭、1995年日本阪神和1999年台湾集集地震中，由于不能有效地控制结构破坏而带来了巨大的经济损失[4-5]，远远超出了预先的估计。

You don't want to default on your loan and ruin your credit score.

你不能在借贷上违约，会破坏你的信用积分，或许你还有其它的选择。

You don't want to default on your loan and ruin your credit score. Maybe there are other options.

你不能在借贷上违约，会破坏你的信用积分，或许你还有其它的选择。

In the framework of non-equilibrium elastoplastic mechanics, the classic finite element method is extended to the analysis for post-failure state of structure, where the plastic complementary energy norm serves as the criterion of global stability while the unbalanced force and its development indicates the pattern and path of destruction.

在非平衡态弹塑性力学框架下，将经典有限元拓展到结构失稳后的分析，塑性余能范数即可作为库群失稳判据，而不平衡力及其发展则表征了库群失稳破坏的形态和演化路径。

The plan calls for an immediate three-year moratorium on logging on 29m hectares while conservation plans to protect woodland caribou are developed; the goal is eventually to distinguish those lands that can be logged using sustainable techniques and those that cannot be logged at all.

这项协议要求在2900万公顷的森林立即实施一项为期三年的暂停商业性林木砍伐计划，同时推出对林地驯鹿的各种保护措施，最终的目标是要划分出哪些林地可以利用不破坏生态平衡的技术进行砍伐，哪些林区完全不能进行商业性伐木作业。

That means Pho85 kinaseand calcineurin were involved in salt tolerance with an identical target protein or in 中科院上海生化与细胞所博士学位论文摘要 the same pathway. Inhibition of calcineurin decrease the YPH499, pho80? mutant,and pap1 (pcl7)? mutant Mn2+ tolerance but not that of pho85? mutant and thepho85? mutant was more sensitive to Mn2+ than YPH499, pho80? mutant, and pap1(pcl7)? mutant even with the addition of cyclosporin A. Therefore, the conclusioncould be drawn that PHO85 gene played a dominant role in Mn2+ homeostasisregulation in compare with calcineurin. As for Ca2+ tolerance, cyclosporin A canincrease the tolerance to Ca2+ of all the mutant mention above, that means Pho85kinase and calcineurin function antagonistically in regulation of Ca2+ homeostasis.In Bioinformatics, BRI3 gene is a novel gene without any function clue but givehigh conservation in mammalian.

我们通过钙调磷酸酶的特异抑制剂环孢菌素A研究了YPH499、+2+pho85缺失株、pho80缺失株、pap1缺失株在钙调磷酸酶失活后对Na、Mn、2+Ca金属离子敏感性的变化，结果显示Pho85蛋白激酶和钙调磷酸酶通过直接+或间接激活同一个靶蛋白或途径来增强细胞对Na的耐受；和钙调磷酸酶相比，2+PHO85的缺失对酵母细胞Mn耐受性的破坏是相对控制性的，钙调磷酸酶的失2+活不能进一步降低pho85缺失株对Mn的耐受能力；Pho85和钙调磷酸酶在对2+Ca的耐受调节中是相互拮抗的，钙调磷酸酶的失活能增加pho85缺失株和2+pho80缺失株的Ca耐受。i中科院上海生化与细胞所博士学位论文摘要对本实验室克隆的人新基因BRI3进行系统的生物信息学分析，发现它是一个在哺乳动物中保守的，但功能未知的基因。

The nanoplex were smaller than the unmodified nHAP; thelipiodol/nanoplex emulsion, with the mean diameter at 75±11.8nm can disperse moreuniformly and be more soluble and stable, contrary to the unmodified nHAP and nanoplex Conclusion: Nanoplex/pDNA mass ratios greater than 15 had exhibited completepDNA absorption onto positive charged polyplex and pDNA protection from thedestruction of nucleinase in rabbit serum. Unmodified nHAP may can\'t induce effectivegene delivery.PartⅡThe construction of the recombint eukaryotic expressive vector ofwild-type human p53 and RbObjective: To construct the recombint eukaryotic expressive vector of wild-type humanp53 and Rb by utilizing the theory of molecular medicine.

结果nHAP颗粒本身大小小于100nm，但由于颗粒表面本身带负电，不能包括有效地结合及保护DNA；经Ca~(2+)修饰后，颗粒可带正电，可一定程度地结合和保护DNA，但聚合物本身的中性电与带负电的细胞膜结合，而且本身的颗粒则变地容易聚集而成为很大的颗粒，也不利于细胞的吞噬；经PLL修饰后，颗粒溶解性提高，直径变小，表面带正电，电泳结果显示PLL-nHAP颗粒可包括有效地结合和保护DNA免受兔血清的破坏，而且复合物表面的正电也包括有利于与细胞膜的结合与吞噬。

Therefore, non-contact temperature measurement technique becomes the development trend of high temperature measurement and will be used more and more widely in measuring the temperature field of weld arc and pool.

非接触测温主要有辐射法和干涉法，由于测温元件不与被测物接触，不会破坏被测物的温度场，通过与数字图象处理技术相结合，能实现温度场的快速、实时测量，全面、形象的反映温度场的动态变化，因此成为高温测量技术的发展趋势，在焊接熔池和电弧温度场测量中得到越来越多的应用。

But, if I may even flatter myself that they may be productive of some partial benefit, some occasional good; that they may now and then recur to moderate the fury of party spirit, to warn against the mischiefs of foreign intrigue, to guard against the impostures of pretended patriotism; this hope will be a full recompense for the solicitude for your welfare, by which they have been dictated.

如果我们在一个称职的政府领导下保持团结，在不久的将来，我们就可以不怕外来干扰造成的物质破坏；我们就可以采取一种姿态，使我们在任何时候决心保持中立时，都可得到它国严正的尊重；好战国家不能从我们这里获得好处时，也不敢轻易冒险向我们挑战；我们可以在正义的指引下依照自己的利益，在和战问题上作出抉择。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。