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On the establishment of shielding immune cells avoid HIV viral antigens identified protein adsorption and the establishment of "biological trap" induce HIV models Summary : HIV is the human immunodeficiency virus caused AIDS virus, AIDS is not currently be fully human control, AIDS vaccine is being developed, but because the virus genetic diversity potential to change the topic of the complexity of this ban from the incidence of HIV spread T4 cells in the mechanisms by, proposed changes T4 lymphocyte surface protein CD4 receptors structure as to avoid HIV adsorption, and the establishment of "biological trap" booby HIV idea to try to turn on AIDS treatment to the conversion of protein structure and function, as well as synthetic direction.

提要:HIV即人类免疫缺陷病毒是引起AIDS的病毒,目前爱滋病还不能被人类完全控制,AIDS的疫苗也正在研制中,但是由于病毒多样性的遗传潜能,使这一课题变的很复杂,本文试从HIV侵染T4细胞导致发病的机理入手,提出改变T4淋巴细胞表面CD4受体蛋白构象以避免HIV吸附,并设置"生物陷阱"诱杀HIV的构想,试图把对爱滋病的治疗引向对蛋白质结构与功能转化以及合成的方向。

Penicillin is able to not only kill the bacteria without damaging human cells due to penicillin Penicillium contained n the synthesis of cell wall of bacteria can occur obstacles, resulting in the death of the bacteria dissolved, and human and animal cells, there is no cell wall.

青霉素之所以能既杀死病菌,又不损害人体细胞,原因在于青霉素所含的青霉烷能使病菌细胞壁的合成发生障碍,导致病菌溶解死亡,而人和动物的细胞则没有细胞壁。

Wenxin capsule can promote endolethial cells releasing CO and synthesing 〓, enhance activity of HO, induce angiectasis through activating guanylic cyclase and adenglate cyclate of intracellar of vessel smooth muscle cell to enhance content of intracellar cGMP and AMP. 3. Wenxin capsule can inhibit releasing of platelet activiting factor 〓 which inhibit platelet aggregation and have antithrombosis function. 4. Wenxin capsule can promote activity of t-PA, reduce activity of PAI-1, strengthen fibrinolytic function, therefore inhibit fibrin disposition. 5. Wenxin capsule can inhibit synthesis of smooth muscle cellular DNA. Its function don't kill it directly but prevent transformation from period Go to peried S. 6. Wenxin capsule is an effective prescription of anti-coronary atherosclerosis atherosis. The results of image pattern analysis tastifies that area of lipid plaque in treating group reduce 54% and 58% in contrast with that in control group. The results of light, electro- microscopy show that structure of endolethial cell and smooth muscle cell in treating group is more integral than that in control group.

其作用机制之一是由于该药具有良好的调脂降脂作用,其不仅能明显降低血清LDL-c及升高HDL-c含量,且能有效阻止TC沉积于血管壁,从而保护内皮细胞结构完整;此外,温心胶囊尚具有明显的抗氧化作用,该药不仅能明显降低血浆LPO含量,且能提高SOD活性,同时其对血红素在细胞内代谢的调节作用也参与了抗氧化过程。2 温心胶囊能明显促进内皮细胞释放CO及合成〓,提高HO活性,通过激活血管平滑肌细胞内鸟苷酸环化酶及腺苷酸环化酶引起细胞内cGMP、AMP浓度增加而引起血管舒张。3 温心胶囊能明显抑制血小板激活因子〓的释放,从而抑制血小板聚集,抗血栓形成。4 温心胶囊能明显提高t-PA活性,降低PAI-1活性,增强纤溶功能,从而抑制纤维蛋白沉积。5 温心胶囊能明显抑制平滑肌细胞DNA合成,其抑制作用不是直接杀伤抑制,而是阻止细胞由Go期向S期转化。6 温心胶囊是抗冠状动脉粥样硬化的有效制剂,图象分析结果证实,该药治疗组脂斑面积比对照组缩小了54%和58%,光电镜结果显示内皮细胞及平滑肌细胞结构较为完整。

The Knoevenagel condensation reactions between aromatic and α,β-unsaturated aromatic aldehydes with barbituric acid can effectively be performed in ionic liquid without additional acid or base catalyst, it is a simple efficient method for the synthesis of benzylidene barbituric acids, which have been widely used in pharmaceutical chemistry as well as in organic synthesis.

芳醛、α,β-不饱和芳醛和巴比妥酸间的Knoevenagel缩合反应能在离子液体中没有酸碱催化剂的条件下顺利进行,是合成在药物化学和有机合成中有广泛用途的苯亚甲基巴比妥酸类化合物的简单有效的方法。

Reaction of 5'-O-p-methoxytrityl-thymidine with 1, 1'-carbonyl-diimidazole gave the 3'-O-carbonylimidazolide, which was condensed in high yield with 3'-O-protected thymidine to give a dithymidine carbonate. In the same way, we obtained the protected trithymidine dicarbonate. After deprotection, we obtained quantatively the trithymidine dicarbonate.By the same stratagy, we completed the synthesis of dithymidine sulfite.It was shown that allyl can be used as a good protection group for hydroxyl of ribose in the synthesis of oligonucleotides consisting in some unstable nucleotide analogues.

我们在第一部分工作的基础上,以烯丙基作为3'-OH的保护基合成了保护的三胸苷碳酸酯以及二胸苷亚硫酸酯,用我们所得的脱保护条件进行了脱保护研究,得到了三胸苷碳酸酯以及二胸苷亚硫酸酯,并研究了它们合成中的一些化学问题,结果表明:烯丙基能很好地运用于这两类寡核苷酸类似物的合成中,其脱保护条件为中性,不会影响碳酸酯键及亚硫酸酯键。

Also studied was aza Diels-Alder reaction catalyzed by polyclonal antibody. The bicyclic [2, 2, 2] heptene and the aimed immunogen were synthesized via the key intermolecular asymmetric aza Diels-Alder reaction. Then four polyclonal antibodies were obtained by immunizing rabbit.

在研究多克隆抗体催化氮杂Diels-Alder反应中,通过分子间不对称氮杂Diels—Alder反应为关键反应合成了双环[2,2,2]庚烯类半抗原和目标抗原;用目标抗原免疫动物兔后得到了4株多克隆抗体,经动力学测试表明:多抗Aza-Bsa-3#能催化氮杂Diels—Alder反应的进行。

BACKGROUND: The essence of cell differentiation is a selectively intra-cellular gene expression, which results in specific proteinic synthesis and causes changes in biochemistry, structure and function. Thus, original proteomics and a single protein analysis can not meet the requirement in study.

摘要背景:细胞分化的实质是细胞内基因的选择性表达,导致细胞新的特异性的蛋白质的合成,从而在生化、结构及功能上发生变化,原有的基因组和分析单一蛋白的模式已不能满足研究的需要。

These results reveal that the APC〓 trimers in the core cylinders of phycobilisomes favour a standard face to face manner to associate into a〓 hexamer, but probably, the APC〓 trimers cannot form a stable〓 hexamer like C-PC and R-PE hexamers due to the relatively weaker association between two trimers, but a relatively looser hexamer.

这些结果表明位于藻胆体core cylinder中的APC〓三聚体趋向于以通常的面对面的方式缔合成〓六聚体,但由于六聚体内两个三聚体之间的相对较弱的相互作用,APC三聚体很可能不能形成象C-藻兰和R-藻红一样的稳定的六聚体,而只能形成一个相对松弛的六聚体。

But potentiating effect on IFN-induced growth inhibition was fewer noticeable in 1.4 μg/ml of synthetic peptide.

体外抗病毒结果显示,干扰素在亚保护剂量时(20~70 pg/ml)时,合成肽能提高IFN-α作用细胞后的抗病毒活性,并且合成肽WLDPRH在1.4 μg/ml时, IFN-α抗病毒保护率从40%提高到86%,为最高保护率的最低剂量,但合成肽为1.4 μg/ml, IFN浓度为5~55 ng/ml时,对IFN-α诱导的抗增殖作用不明显。

As one of the most important osmoregulation actor, firstly,Proline plays a keyrole in the osmotic potential adjustment in plant cells. Secondly, Proline can preventNaCl from damaging the structure of biomacromolecule in cells. Thirdly, the highdissolubility and non-rejection capability of Proline can enlarge the solution volumnof the cell, so the concentration of salt will be diminished in cytoplasm and the saltstress will be relieved. Forthly, the accumulation of Proline could prevent thedehydrolysis from sap cavity in cytoplasm. Fifthly, the synthesis of plant chlorophyllwill be diminished under the salt stress, but the Proline can provide request ofchlorophyll synthesis.

脯氨酸作为渗透调节剂对植物体细胞渗透势的变化起重要作用:一,在盐胁迫下,脯氨酸在植物体内是一种重要的渗透调节剂,它是一些高等植物和绿藻抗盐和抗旱的主要渗透剂之一;二,脯氨酸可以保护细胞中的生物大分子的结构,使之不被NaCl破坏,并能维持其完整的水合范围;三,脯氨酸的高度溶解性以及其对植物各种酶活性不抑制性,可以扩大细胞的溶解容积,从而降低细胞质液中盐的浓度,减轻盐的胁迫作用;四,细胞质中积累的大量脯氨酸可以防止液泡对细胞质的脱水作用;五,在盐胁迫下,植物叶绿素的合成受到抑制,叶绿素的合成需要脯氨酸。

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However, as the name(read-only memory)implies, CD disks cannot be written onorchanged in any way.

然而,正如其名字所指出的那样,CD盘不能写,也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

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A single payment file can be uploaded from an ERP system to effect all pan-China RMB payments and overseas payments in all currencies.

付款指令文件可从您的 ERP 系统上传到我们的电子银行系统来只是国内及对海外各种币种付款。