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Targeted deletion of the RIM-BP3 gene in mice resulted in male infertility due to abnormal sperm heads characterized by deformed nucleus as well as detached acrosome.

为了阐明RIM-BP3的敲除引起雄性不育的机制,我们通过亲和纯化的方法寻找RIM-BP3的相互作用蛋白,发现Hook1与RIM-BP3在精子细胞内形成复合物。

Liquidized time of spermatic fluid was exten...

NG、CT、UU感染是男性不育的主要原因之一。

Methods: Real time FQ - PCR testing and germiculture methods adopted for NG,CT,UU testing on spermatic fluids of 105 cases of male infertility and regular spermatic fluid testing.

采用实时荧光定量聚合酶链反应技术对105例男性不育者的精液进行NG、CT、UU检测并做精液常规检查。

The appearance of Round spermatid injection provides a new way to treat the sterile human male .

圆形精细胞卵胞质内显微注射(Round spermatid injection,ROSI)辅助生殖技术的出现为治疗人类男性不育提供了新的途径。

Summary Apoptosis is a common phenomenon during spermatogenesis, and its dysregulation has been associated with male infertility.

凋亡是精子发生中的普遍现象,凋亡的失调控被认为与男性不育的发生有关。

The cloning and identification of these genes are of great value to elucidate the mechanism of spermatogenesis and spermiogenesis.

发现并研究精子发育不同阶段表达的基因及其调控因子,深入研究它们在精子发生中的作用,将有助于阐明精子发生的机理,为探索不育机理和寻找免疫避孕的新途径奠定理论基础。

It is associated with the manchette, a transient microtubular structure believed to be important for morphogenesis during spermiogenesis.

我们在小鼠中进行了RIM-BP3基因的敲除,结果表明它的缺失会引起精子头部发育的异常,如核畸形和顶体脱离等,最终导致雄性不育

The cloning and identification of these genes are of great value to elucidate the mechanism of spermatogenesis and spermiogenesis. Such study can also provide foundation and cues to investigate the mechanism of infertility and immunocontraception.

发现并研究精子发育不同阶段表达的基因及其调控因子,深入研究它们在精子发生中的作用,将有助于阐明精子发生的机理,为探索不育机理和寻找免疫避孕的新途径奠定理论基础。

Cloning of spermatogenesis related genes and further functional study are very important to the elucidation of molecular mechanism involving in spermatogenesis and spermiogenesis process.

克隆睾丸精子发生相关基因并研究其功能,对于揭示精子发生过程中减数分裂和变态的分子机制,对于临床男性不育的诊断和治疗以及男性分子节育等均具有重要的意义。

The identification and study of the control factors that regulate gene expression at different stages are of great value to elucidate the mechanism of spermatogenesis and spermiogenesis. Such study can also provide foundation and cues to investigating the mechanism of infertility and immunological contraception.

作为体内高度分化的雄性生殖细胞,精子发生过程中经历了从形态到生化的复杂变化,在这一过程中有一系列的特定基因按严格的时空顺序转录和翻译,因此寻找和研究不同发育阶段的差异表达的基因,将有助于最终阐明精子发生的机理,并为控制生育和不育机理的探索提供新的线索。

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