不敏感性

Investigation of the sensitivity of a cross-polarized light visualization system to detect subclinical erythema and dryness in women with vulvovaginitis.

关于正交偏振光可视化系统检测临床症状不明显的妇女外阴阴道炎红斑和干燥的敏感性的调查 _文摘译讯_医脉通，www.medlive.cn

Bull; Suitable for use with dry dermatological conditions such dry, scaly skin, winter itch, ichthyosis, xerosis, dermatitis.

本产品采用低刺激的配方，及不含羊毛脂，香芬，色素、丙二醇等成分，所以适合大多数的敏感性皮肤使用。

That means Pho85 kinaseand calcineurin were involved in salt tolerance with an identical target protein or in 中科院上海生化与细胞所博士学位论文摘要 the same pathway. Inhibition of calcineurin decrease the YPH499, pho80? mutant,and pap1 (pcl7)? mutant Mn2+ tolerance but not that of pho85? mutant and thepho85? mutant was more sensitive to Mn2+ than YPH499, pho80? mutant, and pap1(pcl7)? mutant even with the addition of cyclosporin A. Therefore, the conclusioncould be drawn that PHO85 gene played a dominant role in Mn2+ homeostasisregulation in compare with calcineurin. As for Ca2+ tolerance, cyclosporin A canincrease the tolerance to Ca2+ of all the mutant mention above, that means Pho85kinase and calcineurin function antagonistically in regulation of Ca2+ homeostasis.In Bioinformatics, BRI3 gene is a novel gene without any function clue but givehigh conservation in mammalian.

我们通过钙调磷酸酶的特异抑制剂环孢菌素A研究了YPH499、+2+pho85缺失株、pho80缺失株、pap1缺失株在钙调磷酸酶失活后对Na、Mn、2+Ca金属离子敏感性的变化，结果显示Pho85蛋白激酶和钙调磷酸酶通过直接+或间接激活同一个靶蛋白或途径来增强细胞对Na的耐受；和钙调磷酸酶相比，2+PHO85的缺失对酵母细胞Mn耐受性的破坏是相对控制性的，钙调磷酸酶的失2+活不能进一步降低pho85缺失株对Mn的耐受能力；Pho85和钙调磷酸酶在对2+Ca的耐受调节中是相互拮抗的，钙调磷酸酶的失活能增加pho85缺失株和2+pho80缺失株的Ca耐受。i中科院上海生化与细胞所博士学位论文摘要对本实验室克隆的人新基因BRI3进行系统的生物信息学分析，发现它是一个在哺乳动物中保守的，但功能未知的基因。

The presterssed anchor cable frame combined with backwall, drainage is necessary due to longtime sability and permanent utilization.Firstly,according the study of engineering of geology situation of the high slope, the mechanism of deformation failure and the major hazard of the high slope of PanMei is analysed comprehensively.And the whole slope is divided into two different geology enginnering areas:Western slope(1160 section plane -1240 section plane)and Eastern slope(1240 section plane -1320 section plane). The result of 3D numerical simulation is the same as geology judgement. Later,slope cut (1:0.75) is implemented based on the engineering comparison and criterion.Meanwhile, Limit equilibrium method , Monte Carlo Probabilistic slope stability the stability , Sensitivity analysis and Finent element method of for assessing the cutted slope stability is carried out. The result indicates that Western slope is instable, Eastern slope is relatively stable.So much attention should be paid to Western slope.Different reinforcement measures in different areas are given according to its stability and meet economical request. Gravity wall is introduced in accordance with landform in order to prevent small falling at the foot of the high slope ,which will be a threat to the high slope stability. Handling measure is also applied to Eastern slope. At last,FLAC3D numerical analysis shows the feasibility and reasonableness of the handling measure of the high slope.

论文首先研究了边坡的工程地质条件，全面分析边坡的变形破坏机制和边坡的主要地质灾害，将边坡分为西段不稳定边坡区(1160剖面～1240剖面)和东段相对稳定边坡区(1240剖面～1320剖面)，通过三维数值模拟再现了边坡在自重作用下的破坏机制和过程；在此基础上通过工程类比和规范要求，确定按照1：0.75进行放坡处理，并分析了放坡后边坡的稳定性状况，分别通过极限平衡法、蒙特卡洛法概率分析、参数敏感性分析和有限元稳定性计算等多种方法对边坡在各种工况下的进行稳定性研究，计算结果表明，西段边坡较之东段边坡稳定情况差，是边坡支护的关键之处，而东段边坡相对是稳定的；边坡的综合治理措施选用的是框架锚索并结合挡土墙和排水工程，治理设计根据不同区段的稳定性情况采用不同的支护结构，做到了经济合理的要求；在边坡的坡脚设置重力式挡土墙，防治边坡小规模的崩塌，会对上部的锚索支护护造成不利影响，进而影响边坡的稳定；东段边坡的填方区也给出了治理对策；最后通过三维显示拉各朗日有限差分程序(FLAC3D)模拟了高边坡放坡和支护效果，论证了治理措施的有效性和合理性。

After treatment of benzamide which is an inhibitor of poly polymerase,β-galactosidase activity assays and PCR analysis were performed to test the deletion of LacZ gene and c-Ha-T24ras gene. The results showed that:(1)LacZ gene was deleted from both A13.4-NIH3T3 cells and B12.7-NIH3T3 cells, but neigher from A13.4-HeLa cells nor B12.7-HeLa cells. So it is possible that there is cell line specificity in gene deletion induced by BA.(2) In A13.4-NIH3T3 cells, LacZ gene and c-Ha-T24ras gene were completely deleted at the same time.(3) The transcription activity of exgenous DNA fragment may have same effect on its sensitivity to the deletion induced by BA.

用聚ADP核糖聚合酶的NAD位点抑制剂苯甲酰胺分别处理四种转化细胞后，检测细胞中整合的外源LacZ基因与c-Ha-T24ras基因的删除情况，结果如下：BA诱导的基因删除可发生于NIH3T3转化细胞系，但不能发生于HeLa转化细胞系；位于同一外源表达载体上的LacZ基因与c-Ha-T24ras基因的删除过程是同步的；外源整合DNA片段的转录强度可能直接影响其被BA诱导删除的敏感性。

Use of bronchoscopy with bronchoalveolar lavage did not increase diagnostic sensitivity.

支气管肺泡灌洗的支气管镜检查不能增加诊断敏感性。

The CA125 is an epitope on a large mucin glycoprotein molecule of greater than 1 million Daltons,normal expressed on the coelomic epithelium,including ovarian surface.By now,CA125 assay has been used for monitoring response to primary treatment,detecting clinically occult ovarian cancer at the time of recurrence,as well detecting primary disease in early stage.The CA125 level is abnormal in over 90%of advanced stage ovarian cancer,but it is not increased in about 50%of the patients with stageⅠdisease.

卵巢癌肿瘤标记物中最常用的是CA125，它是体腔上皮正常表达的一种抗原蛋白，晚期卵巢癌中，超过90%病例CA125升高，而在Ⅰ期卵巢癌中，大约有50%病例CA125正常，因此血清CA125敏感性和特异性不能满足筛查指标的要求。

The range of MIC90 was-10 μg/ml. The susceptibility rates of the strains to other 10 agents were nearly or equal to 0%. Different plasmid profile strains had almost the same antimicrobial susceptibilities. 25 strains (including 18 strains harboring 34-80×106 plasmids) selectively examined to have no self-transmissible conjugative plasmid.

88.6%，MIC90为-10 μg/ml），对卡那霉素等其余10种药物的敏感率很低或不敏感，不同质粒谱菌株对药物的敏感性几乎相同，对包括 18株含34-80×106质粒在内的 25株菌进行接合转移试验，未检出传递性耐药性质粒。

Other examples of political sensitivity abound. In 2006 the New York Theatre Workshop cancelled a planned production of "My Name is Rachel Corrie", a play about an American student killed by an Israeli Defence Forces bulldozer.

政治敏感性的其他例子不甚枚举。2006年，纽约戏剧工作室取消原定上演的&我叫瑞秋科丽&，这是一出关于一名美国学生被以色列国防军的推土机压死的戏剧。

The growth inhibiting rate of T24 cell lines were detected by MTT methods, apoptosis of cells were detected by flow cytometry, the mechanism of apoptosis was analyzed by detecting the protein expression of Bcl-2, Bax, Caspase-9, Caspase-3 and cytoplastic protein Cytochrome C. 4 We injected live T24 cells into the subcutaneous space of nude mice and successfully built up the animal model of bladder carcinoma. The effect of CS-PAA-EPI polymer magnetic microspheres targeting chemotherapy was investigated by HE staining, TUNEL ,tumor weight and volume inhibition rate. Results: 1 TEM revealed that the CS-PAA polymer magnetic microspheres were regular spherical shape,the average diameter was 80nm in dry condition. By controlling the pH value of the medium,polymers had positive or negative zeta potential. VSM showed the CS-PAA polymer magnetic microspheres had superparamagnetic. The diameter of CS-PAA-EPI polymer magnetic microspheres were 200nm in solution by DLS examining,the embedding ratio was 20%,the EPI loading rate was 15%, which was higer than reported in other articles. 2 Raw eye observation found that the rat"s bladder of treatment group was brown color,which meaned the aggregation of iron particles, compared with the control group, iron stain found iron particles were assembled in rat"s bladder of the treatment group, the amount of iron particles in liver and spleen were less obviously.

研究结果：1合成的CS-PAA磁性聚合物微球呈球形，大小均一，TEM测定其干态下粒径为80nm左右，磁化曲线证实具有超顺磁性，具有一定的PH敏感性，固载表柔比星后，水溶液性状稳定，无沉淀物，DLS测定直径约200nm左右，测定载药率为15％，较文献报道高，包封率为20％。2肉眼观察试验组大鼠膀胱表面呈褐色，可见大量的Fe粒子聚集，普鲁士兰染色法显示，试验组大鼠膀胱壁内有大量的Fe粒子，分布至膀胱壁全层，与对照组大鼠相比，试验组大鼠的肝、脾内的Fe粒子聚集量明显降低；HPLC测定结果与Fe染色相同；高剂量磁性CS-PAA-EPI生理盐水组及单纯EPI生理盐水组均在给药后14天出现血肌酐和尿素氮的升高，其他组大鼠血生化指标没有明显变化。3MTT法发现，高、中、低剂量磁性CS-PAA-EPI生理盐水组在外加磁场的协同作用下杀伤T24细胞效应明显高于单纯的EPI生理盐水组，FCM发现试验药物组可引起明显的肿瘤细胞凋亡，试验药物治疗组细胞胞浆内出现了由线粒体释放出的细胞色素C，试验组细胞Bcl-2蛋白减少，Bax蛋白变化不明显，Caspase-3、Caspase-9蛋白受到了激活活化。4高、中、低剂量磁性CS-PAA-EPI生理盐水组的瘤重抑制率和瘤体积抑制率均明显高于单纯的EPI生理盐水组(P＜0.01)，其中高剂量组的抑制率最高。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。