不凋的

The results showed that the structure of mammary gland without leptin keep normal and there were little apoptosis cells in them. But in explants with leptin, the duct and gland alveolus collapsed and the apoptosis cells increased. It showed that leptin induced mammary gland apoptosis

结果显示，不加瘦素培养的组织形态保持较好，凋亡细胞较少；加瘦素培养组织的导管和腺泡结构已经开始发生解体，组织中有较多的凋亡细胞，证明瘦素在退化期乳腺组织中可明显诱导细胞凋亡。

The researching result of this field is conflicting in these years. Some researchers consider it as apoptosis, while some necropsy results don\'t support the hypothesis. Our study is to investigate the protein expression and biochemistry changes under oxidative stress to determine if apoptosis happens.

多巴胺能神经元的死亡是凋亡还是坏死目前的研究结果不一，有许多的研究说明在氧化应激的条件下，细胞的死亡是凋亡，而部分尸检结果不支持凋亡的学说，本实验拟从蛋白表达及生化学方面观察氧化应激后细胞有无凋亡的发生。

The expression of Bcl-2 was weak or negative; there is no difference among various groups.Research Conclusion: lCadmium can accelerate the apoptosis of GCs and is related with dose; 2Cadmium accelerate atresic of follicular; and increase the number of interstitial gland;3Cadmium enhance the expression of bax, and no affect obviously on bcl-2;4 Selenium restrained the effect of cadmium-induced apoptosis on granulosa cells, but it cant be interdicted completely.

实验结论：1 镉能促进小鼠卵巢颗粒细胞凋亡，并具有剂量效应关系。2 镉能促进卵泡闭锁，使卵巢间质腺数量增加。3 镉能增强颗粒细胞凋亡相关基因bax的表达，对bcl-2的表达则无明显影响。4 硒具有一定的抑制镉致颗粒细胞凋亡的作用，但不能完全阻断。

And there were no evidence changes in histopathologic analysis of brain tissues in other ETU-injected and in control rat embryos. 2. Results of In situ cell apoptosis detection In E20 cerebral cortex, more Tunel cells were found in encephalocoele group than control group,and the results were significant.

二、应用细胞凋亡原位检测法检测不同组E20胎鼠大脑皮质中细胞凋亡情况 E20胎鼠大脑皮质中Tunel阳性细胞数目在正常组、给药无畸形组及脊柱裂组细胞凋亡数无明显改变，而在脑膨出组胎鼠大脑皮质细胞凋亡数明显多于对照组，计算凋亡细胞百分率，然后用X~2检验进行分析，脑膨出组和对照组的细胞凋亡指数差异有统计学意义(P.05)。

Result Compared to concurrent control groups, neuromotor function are significantly improved in 1h and 6h experiment group. The indexes of neural cell apoptosis decreased significantly (P 0.01). But in 24h experiment group, the decrease of the index are not statistically significant. Conclusion Early application of rhEPO could lessen the lesion of neuromotor function. The protection is partially due to the reduction of neural cell apoptosis.

结果：与对照组相比，脊髓损伤后促红细胞生成素1小时，6小时实验组神经运动功能明显改善，脊髓神经细胞凋亡指数均明显下降(P 0.01)；而术后24小时组与对照组相比，脊髓神经细胞凋亡指数的下降无统计学意义结论：早期应用外源性EPO对脊髓不完全损伤后引起的神经运动功能损害具有保护作用，此种保护作用可能与EPO能够减少神经细胞凋亡有关。

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速，应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等，其中自杀基因被认为是最有前景的基因治疗方法，它又称病毒介导的酶／药物前体疗法，是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中，该基因表达的产物可将无毒的药物前体转化为毒性药物，从而选择性杀伤该肿瘤细胞，常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因，前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物，然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷，作为DNA合成链的终止剂和DNA合成酶的抑制剂，干扰细胞DNA的合成；后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶（5-FC）脱氨成为5-氟尿嘧啶（5-FU），然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸（5-FUTP）和5-氟-2′脱氧尿嘧啶-5′磷酸（5-FdUTP），5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成，5-FdUTP则作用于胸苷合成酶，导致TMP衰竭而阻止DNA的合成，最终诱导肿瘤细胞凋亡。

The result showed that PSexternalization. This observation suggested that apoptotic neurons losed membranephospholipid asymmetry and exposed PS on the outer leaflet of the plasmamembrane. Macrophages then phagocytose apoptotic neurons after specific recognition of theexposed PS.

流式细胞术检测磷脂酰丝氨酸，结果表明凋亡的神经细胞PS外翻，证明AVM可使凋亡的神经细胞膜丧失不对称性，细胞膜中的PS由脂膜内侧翻向外侧，可被吞噬细胞识别后导致凋亡细胞的清除。

These results indiacated that tranferring macrophages combinedwith cytokines could be a new adoptive immunotherapy protocol foradvanced cancer,and rTNF used in vivo locally could induce andactivate macrophages to kill tumor cells.Monocytes when activatedunderwent a series of phenotypic and functional changes includingthe expression of IL-2R which may provide an important immunoregu-latory pathway.The presence of lectin-like molecules on thesurface of monocytes and tumor cells may bring theeffector/target cells together,thus facilitating the inductionof apoptosis in target cells by triggering the production ofcytolytic factors and the modification of target of targer cell surface anti-gens.(such as HLA-DR).

综合以上结果可以得出以下结论：转输巨噬细胞并结合细胞因子的联合应用是肿瘤继承性免疫中的又一新的、有潜力的方法；抗肿瘤细胞因子rTNF可通过激活巨噬细胞在体内抑制对其不敏感的肿瘤细胞的生长；人单核细胞在一定条件下激活后，可表达IL-2R，进而一方面增强其自身对IL-2的敏感性，另一方面在体内也具有调节T细胞功能的作用；单核细胞和肿瘤细胞上存在的凝集素类受体可促使两种细胞之间在凝集素介导下相互接近，并诱发单核细胞产生细胞毒因子，以及通过调节靶细胞上表面抗原的表达，促进诱导靶细胞的细胞凋亡。

Recently, it is found that the neuron apoptosis caused by brain ischemia is associated with signal pathway of endoplasmic reticulum stress, which is different from the traditional apoptotic pathway. Caspase-12 has been identified as a molecule which initiates apoptosis selectively in response to ER stress and is not activated by other pathways. Caspase-12 is localized on the ER membrane, but once specifically activated by ER stress, it translocates to the cytoplasm.

最近的研究发现，这种细胞凋亡与内质网应激(endoplasmic reticulum stress ER stress)有关，其是一种不同于经典的凋亡途径的新途径，分子伴侣葡萄糖调节蛋白78(glucose regulated protein， GRP78/Bip)表达增高是反应ER stress的最敏感的指标，胱冬酶-12(caspase-12)为鼠源性的内质网膜上的蛋白，它的特点是只被内质网诱导的凋亡所激活而不被其它非内质网因素所激活。

The effect of AA on BEL-7402 was not significant; However, AA could effectively enhance AT-induced hepatocarcinoma cell apoptosis and lesion severity through activation of caspase-3 but not ERKs-Conclusion; Caspase-3 and ERKs proteins could involve in arsenic-induced hepatocarcinoma cell apoptosis and differentiation respectively as intracellular signaling molecules; The effect between AT and AA on hepatocarcinoma is synergistic, which further inhibits cell growth and induces apoptosis in human hepatocarcinoma cells through activation of caspase-3 but not ERRs.

AA对BEL-7402无明显的作用，但能有效的通过caspase-3而不是ERKs的激活促进AT对肝癌细胞的凋亡效应。结论：ERKs和caspse-3信号蛋白可能分别参与了砷剂诱导的人肝癌细胞促分化和凋亡效应，AT和AA对肝癌细胞的作用有协同性，他们通过caaspase-3而不是ERKs的激活进一步抑制了肝癌的生长，诱导其凋亡。

We have no common name for a mime of Sophron or Xenarchus and a Socratic Conversation; and we should still be without one even if the imitation in the two instances were in trimeters or elegiacs or some other kind of verse--though it is the way with people to tack on 'poet' to the name of a metre, and talk of elegiac-poets and epic-poets, thinking that they call them poets not by reason of the imitative nature of their work, but indiscriminately by reason of the metre they write in.

索夫农 、森那库斯和苏格拉底式的对话采用的模仿没有一个公共的名称；三音步诗、挽歌体或其他类型的诗的模仿也没有——人们把&诗人&这一名词和格律名称结合到一起，称之为挽歌体诗人或者史诗诗人，他们被称为诗人，似乎只是因为遵守格律写作，而非他们作品的模仿本质。

The relationship between communicative competence and grammar teaching should be that of the ends and the means.

交际能力和语法的关系应该是目标与途径的关系。