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Results:(1) Progesterone-treated models showed intact nasal mucosa, regular ciliary lining and inactive glands;(2) Untreated or normal saline treated models showed disrupted mucosa, inverted cilia and massive mucosal infiltration of neutrophils;(3) Smearing of nasal discharge revealed limited vs abundant number of neutrophils in SD models treated with progesterone vs untreated or treated with normal saline.(4) Hoechst stain: significantly fewer apoptotic cells per field were found in progesterone-treated models (1.583 ± 0.28) compared with untreated or normal saline treated models (2.85 ± 0.285 and 4.8 ± 0.715, respectively).

结果:(1)用黄体酮滴鼻液治疗的SD大鼠鼻腔黏膜上皮完整,纤毛整齐,腺体开放不多;(2)用或不用生理盐水滴鼻液治疗的SD大鼠鼻腔黏膜上皮纤毛倒伏,上皮结构散乱,上皮层大量中性粒细胞浸润;(3)鼻腔分泌物涂片示黄体酮滴鼻液治疗的SD大鼠有少许中性粒细胞,而用或不用生理盐水滴鼻液治疗的SD大鼠鼻腔分泌物含有大量中性粒细胞;(4)Hoechst染色:用黄体酮滴鼻液治疗的SD大鼠鼻腔黏膜上皮凋亡细胞数[(1.583±0.28)/视野]明显少于用或不用生理盐水滴鼻液治疗的SD大鼠[分别是(2.85±0.285)/视野和(4.8±0.715)/视野]。

The key to using aberrant energy metabolism as a way to enhance site affinity that specifically targets the cancerous tumor cells' microenvironment that produces measurable tumor selective alkalinization involves administering an alkaline composition that has little toxicity to normal healthy viable cells which preferentially targets and elevates the pH level of the tumor micro-environment, thus causing the non-viability and apoptosis of tumor cells.

可使用异常能量新城代谢来提高癌瘤位置的亲和力,使癌瘤进行具有可测性、可选性的碱化,从而专门改变癌瘤细胞的微环境。其关键在于使用一种对正常健康活性细胞无毒性的碱性制剂,能优先提高癌瘤微环境的pH水平,从而使癌瘤细胞不具有生存能力,促使其凋亡。

As the DDP group A549DDP cells were treated with IC10 of cisplatin for 48 hours. As the DDP+Rh2 group A549DDP cells were treated with IC10 of cisplatin and IC5 of gensenoside Rh2 for 48 hours. As the controlling group A549DDP cells were not treated with any kinds of drugs. Changes in cellular morphology were observed by fluorescence microscopy. Peak value apoptosis of A549DDP cells were inspected by flow cytometry. State of PTP was evaluated by ultraviolate spectrofluorometer. Changs of calcium in cells and membrane potential of mitochondrion were determined by flow cytometry. Release of cyt-c from mitochondrion with westton blot Radiative activity of〓Tc-MIBI ingested by cells was measured withγcounter. Results: IC50 of cisplatine to A549 cells was 24uM.

以无毒浓度的Rh2单独作用于A549DDP细胞作为Rh2组,以低效浓度的顺铂单独作用于A549DDP细胞作为DDP组,以无毒浓度的Rh2和低效浓度的顺铂联合作用于A549DDP细胞作为Rh2+DDP组,作用时间为48小时,以不加药物干预作为对照组,Hoechst33258染色荧光显微镜下观察细胞形态的变化,流式细胞仪检测细胞凋亡峰;紫外光分光光度计检测线粒体PTP开放情况,流式细胞仪检测细胞内钙离子浓度及线粒体跨膜电位的变化,Westton blot检测线粒体内细胞色素C释放情况及Caspase-3的活性,γ计数仪检测细胞摄取〓Tc-MIBI放射性活性。

In contrast to prior belief, tumor cell apoptosis is not necessarilysilent but can be immunogenic.

与先前的想法相反,肿瘤细胞的凋亡可以不保持沉默而具有免疫源性的。

We should work towards creating an even arc in the spine,刑 rather than muscling through and focusing on the size of the pose.

凤我们应当想象脊柱是一个有弧型伸展的运动趋势,凋而不是仅仅让肌肉努力的工作或仅关注于体式的程度。

Methods: Eleven B-CLL patients were studied. Leukemic lymphocytes with (n=8) or without (n=3) P2z receptors were exposed in vitro to ATP, benzoylbenzoic-ATP, 2-methylthio-ATP(2MeSATP), adenosine-5′-[γ-thio] triphosphate, and other nucleosides for 8h. Apoptosis was detected by electron microscopy, agarose gel electrophoresis, and quantitative TdT assay. Results:Apoptosis was detected only in leukemic lymphocytes with P2z receptors. By using the quantitative assay, ATP-inducing DNA strand breaks were found to occur specifically for BzATP, ATP and 2MeSATP, but not for ATP-γS and other nucleosides.

将表达P2z受体[P2z]与不含P2z受体[P2z]的两组CLL细胞分别同1.0mmol/L三磷酸腺苷体外培养8小时,以电镜、DNA凝胶电泳和定量DNA 3′端TdT法检测细胞凋亡;并对ATP、苯甲酰苯甲酸ATP、2-甲基硫ATP(2MeSATP)、γ-硫代ATP及其它核苷的诱导效应和氧化型ATP、1-[N,O-二(5-异喹啉碘酰基)N-甲基-L-酪氨酰]-4-苯哌嗪KN-62)的抑制效应做定量研究。

Results:(1)After the action of electrets, 10%of 3T3 cells appeared apoptosis.(2) After the action of electrets in 3T3 cells, the free Ca2+ levels in cellular plasm were increased. The increasement of Ca2+ levels was caused by the Ca2+ inflow from outside cell, rather than the release of calcium pool inside cell.

结果:(1)负极性驻极体作用3T3细胞后,3T3细胞出现10%的凋亡量;(2)驻极体作用3T3细胞以后,细胞质游离Ca2+浓度升高,Ca2+浓度的升高不是由于细胞内钙池的释放,而是由于细胞外Ca2+内流所引起。

The effect of AA on BEL-7402 was not significant; However, AA could effectively enhance AT-induced hepatocarcinoma cell apoptosis and lesion severity through activation of caspase-3 but not ERKs.

AA对BEL-7402无明显的作用,但能有效的通过caspase-3而不是ERKs的激活促进AT对肝癌细胞的凋亡效应。

Where but to think is to be full of sorrow,and leaden-eyed dispairs,where beauty cannot keep her lustrous eye.Or new love pine at them beyond to-morrow.

在这里,稍一思索就充满了忧伤和灰色的绝望,而&美&保持不住明眸的光彩,新生的爱情活不到明天就枯凋。

Permanent wilting point The point at which soil has dried to the extent that plants can no longer remove the remaining water held on the soil particles,and begin to wilt and will not recover,even if moved to a cool,dark place,unless more water is added to the soil.

永久萎蔫点:指土壤干旱的程度足以引起植物不再能从土壤中吸收水分,开始凋萎,即使是将其移到阴凉、黑暗的地方,也不能再次恢复,除非给土壤中添加更多的水。

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We have no common name for a mime of Sophron or Xenarchus and a Socratic Conversation; and we should still be without one even if the imitation in the two instances were in trimeters or elegiacs or some other kind of verse--though it is the way with people to tack on 'poet' to the name of a metre, and talk of elegiac-poets and epic-poets, thinking that they call them poets not by reason of the imitative nature of their work, but indiscriminately by reason of the metre they write in.

索夫农 、森那库斯和苏格拉底式的对话采用的模仿没有一个公共的名称;三音步诗、挽歌体或其他类型的诗的模仿也没有——人们把&诗人&这一名词和格律名称结合到一起,称之为挽歌体诗人或者史诗诗人,他们被称为诗人,似乎只是因为遵守格律写作,而非他们作品的模仿本质。

The relationship between communicative competence and grammar teaching should be that of the ends and the means.

交际能力和语法的关系应该是目标与途径的关系。

This is not paper type of business,it's people business,with such huge money involved.

这不是纸上谈兵式的交易,这是人与人的业务,而且涉及金额巨大。