下游

Hes5 gene, a key downstream mediators of Notch signaling that functions by inhibiting the expression or activity of positively acting bHLH factors, is a member of bHLH transcription factor family which acts as a positive-negative transcriptional regulators which is expressed transiently in different stages in cells growth and differentiation and orchestrate those precisely timed and progressive maturational events underlying cell fate decisions according to orders of time and spatial and coordinated the function of majority of signaling transduction on target genes to influence the proliferation and differentiation.

Hes5是Notch通路转导途径的一个关键的下游信号分子，通过抑制正调控bHLH因子的表达和活性来发挥作用，隶属于碱性螺旋-环区-螺旋转录因子家族。该家族形成一个正负转录调节器，按时空顺序短暂表达于细胞发育分化的不同阶段，介导和协调多种信号系统对大量靶基因的作用，影响细胞增殖、分化。

As shown in the past decades, the market fluctuated dramatically in the demand and price. Furthermore, downstream industry of p-xylene required continuously improved purities, 99.2% in 1970's to 99.8% in 1990's.

再过去几十年中，市场需求与价格呈现剧烈变化，同时，基於石化工业下游厂家的需求，对二甲苯纯度亦由1970年代的99.2%，提高到1990年代的99.8%。

High efficiency and low cost protein refolding methods are a highlighted research focus in downstream process of biotechnology.

高效且廉价的蛋白质复性方法的研究一直是生物工程下游技术中的一个热点。

Further downstream, the players in the synthetic PCMO market – Castrol, Pannzoil-Quaker State, and Valvoline – have each released reformulations and new blends in the past several months.

此外下游，在合成轿车发动机油的市场参与者-嘉实多，Pannzoil一奎克国家和胜牌-先后推出了重新表述在过去的几个月，新的混合。

With this, Oerlikon Schlafhorst once again revolutionises the processes of winding technology. Individual package design, maximum flexibility and productivity are performance features of the system that are going to influence the dynamics of the textile market in the future. A pattern-free ackage build, composition of the package properties at the touch of a button on the Informator, flexible format configuration: package engineering as you and your customers want it. You can match the package quality individually and without compromise to the process requirements.

其独一无二的筒子成形，极高的灵活性，至高的产能以及卓越的性能都将引领纺织技术的未来； Preci FX 高度智能，操作简易，用户只需轻触开关，即可轻松调节筒子参数，以满足您的下游客户对筒子规格的不同要求，而且，筒子质量不受络筒方式影响，筒子完全无重叠，且具有优异的特性，从而，实现了筒子质量和产量的双重突破。

Especially the drainage area of upper reaches of Yellow River in northeast Qinghai-Tibet Plateau, the drainage area of upper reaches of Yangtse river, lower reaches of Brahmaputra in southern Tibet and the upper reaches of Nujiang river, Lancangjiang river and Jinshajiang river in southeastern Tibet, are centralized areas that geological hazards occur, in which the earthquakes, rockfalls, landslides and mudflows are most typical, severe, and mostly hazards in human modern engineering activity and living environment.

尤其是青藏高原周缘西北部的黄河上游流域、东南部的长江上游流域、西藏南部的雅鲁藏布江下游区及其东南部的&三江地区&，成为地质灾害事件集中发生的区域，其中的地震、崩滑流、断裂活动等地质灾害效应最为强烈，成为影响现代人类工程活动和生存环境的主要灾害。

If dam breaks, a flash flood could threaten downstream villages.

如果大坝休息，一洪水可能威胁下游村庄。

The RhoA oncogene , have been revealed in recent years, are closely related to various malignant tumours. RhoA, belonging to Rho family, is one member of the ras superfamily, whose encoding production, namely RhoA protein, pertaining to micromolecular mass GTP conjugated protein family, in GTP conjunctive active form and GDP conjunctive unreactive form. It exist in the latter form in normal cells and the switch of the two forms enables them to educe functions, paralleling"molecular switch", the diminutive G protein in activated state being able to activate the wink dromo-iter to work functions, which is in the resemblance of process during which the Ras genic mutation induces its continous activations.

RhoA是近年来新发现的与多种恶性肿瘤密切相关的癌基因，RhoA属于Rho亚家族，是ras基因超家族的一员，其编码产物RhoA蛋白属于小分子量GTP结合蛋白族，分为GTP结合的活性型和GDP结合的非活性型两类，在正常细胞内以GDP结合的非活性型存在，两种活性形式之间的转换使他们能够发挥一种类似&分子开关&的作用，活性态的小G蛋白能激活下游的信号传导通路，行使其功能。

About 900 miles (1,500km) downriver to the east, in Amazonas state, stands Manaus.

沿亚马逊河下游向东900英里（也就是1500公里），在亚马逊洲，马瑙斯市赫然挺立。

It was registered and released in 2002-2004 in Hubei province, Anhwei province, Hunan province, china, and Henan province.

在2000～2002年国家长江下游区试中，两年平均亩产145.05kg，比对照中油821增产15.52％，居参试双低品种首位。2002年通过湖北省和安徽省品种审定，2003年通过湖南省和全国品种审定，2004年通过河南省品种审定和四川省品种认定。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。