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Methods (1)We observed the serial sheet sections of the optic apex region obtained using collodion microtomy in 4 adult cadaver heads;(2)High resolution CT scanning and three dimensional images of the optic apex region were observed and measured in 10 adult volunteers;(3)High resolution magnetic resonance images of the optic apex region were obse.

①采用火棉胶切片技术对4例(8侧)成人眶尖区标本进行连续薄层断层解剖学观察;②使用高分辨力CT及三维重建技术观测10例(20侧)志愿者眶尖区;③观测5例(10侧)志愿者眶尖区高分辨力MRI断层扫描图像;④对30例(60侧)成人干颅骨标本和15例(30侧)成人湿性头颅标本的眶尖区结构进行显微解剖;⑤在手术显微镜和内窥镜下对3例成人头颅湿性标本模拟眶内经颅入路。

After the biomechanical finite element analysis for the three-dimensional reconstruction model, we find the structure of the deformed nose showes the following characteristics: 1, Nasal septum, nasal columella, lateral feet of nasal alar, lateral nasal dorsum are stress concentrated regions, that is the key mechanical positions of deformed nose; 2, Under the static state, nasal deformation has a very small value of stress distribution, under displacement load status, the deformed nasal has a large value of the stress distribution; 3, Ipsilateral nasal columella are the the key mechanical parts of deformed nasal rectify. And lateral nasal alar is also the most stress concentrated areas.

对于重建后的单侧唇裂鼻畸形鼻部模型进行有限元生物力学研究,发现畸形鼻的力学结构呈现以下特点:1、鼻中隔、鼻小柱、鼻翼外侧脚、鼻背外侧是单侧唇裂鼻畸形应力分布的集中部位,也就是畸形鼻部的力学关键部位;2、在静态状态下,畸形鼻部拥有的应力分布值很小,在位移载荷状态下,形变后的畸形鼻部拥有的较大的应力分布值;3、单侧唇裂鼻畸形整复中,鼻小柱患侧部是畸形整复的力学关键部位,其次就是患侧鼻翼部。

It shows that the FE method of tireanalysis under driving state and the method dealing with large slip frictionalcontact problems are correct and reliable. The properties of tires under steady cornering state are studied with FEmethod and experiment. Based on the presented contact solution algorithm, a FEmethod is carried out to analyze the properties of tire under steady corneringstate via imposing slip-rolling-constraints on tire bead nodes which contact therim, and the modules are programmed. The mechanical properties anddeformation of tire under pure steady cornering state and steadycornering-driving state are analyzed, and the results show good agreement withthe experimental data.

对匀速侧滑条件下轮胎侧偏特性进行了试验研究和有限元分析研究,基于本文提出的大滑动摩擦接触问题求解方法,通过在胎圈和轮辋接触节点上施加侧偏滚动约束,得到了匀速侧滑条件下轮胎侧偏特性有限元分析方法,编制了有限元分析模块;利用本文给出的有限元分析方法,分析了轮胎在匀速纯侧滑和侧滑-纵滑联合工况下受力变形特性,分析了侧偏角和载荷对轮胎侧偏特性的影响。

ABSTRACT:OBJECTIVETo study the correlation between anatomic structure of the inferior alveolar nerve canal and dental implantation by measuring mandible innervation esemplarsMETHODSThe intramandibular course of mandibular canal and its dimendion were measured in 15 mandibles with teeth; the relationship between blood vessel and nerve was observed in 5 fresh samples in which the artery was filled; and then the data were analyzed by statisticsRESULTSThe mandibular canal was close to the lingual side and the inferior margin of the mandible, the mandibular canal and the 10mm underside of mandible were parallel in the region of the first and the second molars, it runned outboard to genal aperture when it was hereabout genal aperture, and the blood vessel lay above nerve in the mandibular canalCONCLUSIONIn implant operation performed according to normal anatomy, injury to inferior alveolar nerve may be avoided.

[目的]探讨下颌管的解剖结构与牙种植的关系[方法]选取15具牙列完整的成人离体下颌骨标本和5具经过动脉血管内灌注的新鲜标本,测量下颌骨在每个牙位截面上有关牙槽嵴及下颌管的相关数据,进行统计学分析[结果]牙槽嵴顶以及下方10mm宽度由前向后逐渐增宽;牙槽嵴由上向下逐渐增宽;下颌管位于下颌骨体内下方走行中偏舌侧,并近下颌骨下缘,在下颌第1,2磨牙区下颌管走行与下颌下缘成平行状,在近颏孔处转向外和向颊侧出颏孔;下颌管内血管位于下牙槽神经之上[结论]牙种植术中按正常解剖部位并且侧重颊侧骨板操作,可避免损伤下牙槽神经;如果术中下颌管内突然涌出大量新鲜血液,则提示若继续手术可能损伤下牙槽神经。

ABSTRACT:OBJECTIVETo study the correlation between anatomic structure of the inferior alveolar nerve canal and dental implantation by measuring mandible innervation esemplarsMETHODS The intramandibular course of mandibular canal and its dimendion were measured in 15 mandibles with teeth; the relationship between blood vessel and nerve was observed in 5 fresh samples in which the artery was filled; and then the data were analyzed by statisticsRESULTSThe mandibular canal was close to the lingual side and the inferior margin of the mandible, the mandibular canal and the 10mm underside of mandible were parallel in the region of the first and the second molars, it runned outboard to genal aperture when it was hereabout genal aperture, and the blood vessel lay above nerve in the mandibular canalCONCLUSIONIn implant operation performed according to normal anatomy, injury to inferior alveolar nerve may be avoided.

[目的]探讨下颌管的解剖结构与牙种植的关系[方法]选取15具牙列完整的成人离体下颌骨标本和5具经过动脉血管内灌注的新鲜标本,测量下颌骨在每个牙位截面上有关牙槽嵴及下颌管的相关数据,进行统计学分析[结果]牙槽嵴顶以及下方10mm宽度由前向后逐渐增宽;牙槽嵴由上向下逐渐增宽;下颌管位于下颌骨体内下方走行中偏舌侧,并近下颌骨下缘,在下颌第1,2磨牙区下颌管走行与下颌下缘成平行状,在近颏孔处转向外和向颊侧出颏孔;下颌管内血管位于下牙槽神经之上[结论]牙种植术中按正常解剖部位并且侧重颊侧骨板操作,可避免损伤下牙槽神经;如果术中下颌管内突然涌出大量新鲜血液,则提示若继续手术可能损伤下牙槽神经。

One-sample t test was used in profoundly congenital hearing loss infants and control group,the activated brain areas were:bilateral transverse temporal gyri, superior temporal gyrus,middle temporal gyrus,bilateral insular lobe,bilateral precentral gyrus,postcentral gyrus,bilateral cingulate gyrus,bilateral inferior parietal lobule,bilateral superior parietal lobule,bilateral superior frontal gyrus.

在对极重度感音神经性耳聋患儿和对照组进行组间比较发现,病人组数据减去对照组数据时可见激活的脑区主要有:双侧颞横回、双侧颞上回、双侧颞中回、双侧岛叶、双侧中央前、后回、双侧扣带回、双侧顶下小叶、双侧顶上小叶、双侧额上回等,提示极重度感音神经性耳聋患儿在接受刺激后动用了更多的脑区而且激活强度明显增加。

Lateral crus presented diamond-shaped or long strip,(16.21 ± 2.71) mm in length,(8.45 ± 1.72) mm in width,(1.09 ± 0.18) mm in thickness. Cephalic rim intersected lower edge of lateral nasal cartilage, and slightly covered the lower edge of the lateral nasal cartilage, so that the two were overlapped, but also only the intersection without overlapping. Lateral crus constituted the base of nasal wings. Narrow medial crus formed nasal tip and the frame of front nasal columella, showing posteroinferior curve or S shape,(13.06 ± 2.16) mm in length,(3.79 ± 0.58) mm in width,(1.02 ± 0.18) mm in thickness. The left and right medial crus in the middle were connected by connective tissue, and in the same way connected to the anterior margin of the lateral nasal cartilage.

外侧脚呈菱形或长条形,长(16.21±2.71) mm,宽(8.45±1.72 ) mm,厚(1.09±0.18) mm,头缘与侧鼻软骨下缘相交,并略覆盖侧鼻软骨下缘使二者部分重叠,也可仅相交而无重叠;外侧脚构成鼻翼大部的基础;内侧脚狭细,构成鼻尖和鼻小柱前部的支架,呈向后下的弧形弯曲或S形弯曲,长(13.06±2.16) mm,宽(3.79±0.58) mm,厚(1.02±0.18) mm;左、右内侧脚在正中线借结缔组织相连,并以相同方式连于侧鼻软骨的前下缘。

There were no significant differences for the firing rates in the site of contralateral TNC neurons among during pre-CSD,CSD,and post-CSD (P>0.05).For flunarizine group,the firing rates in the site of ipsilateral TNC neurons during pre-CSD were higher as compared with during CSD(P<0.05).2.1 There were statistical differences on palasma levels of CGRP and SP among the three groups(P<0.05).The levels of CGRP and SP in CSD group were higher than control group(P<0.05).No significant differences on the levels of CGRP and SP in ipsilateral trigeminal ganglia were found among the three groups(P>0.05).2 The number of neurons with positive CGRP and SP immunoreactivity was statistically different in right-sided trigeminal ganglia among the three groups (P<0.05).The number in fight-sided trigeminal ganglia in CSD group was higher as compared with control group(P<0.05).The number in right-sided trigeminal ganglia was statistically higher than that in left-sided trigeminal ganglion in CSD group(P<0.05).3.1 Altered ReHo in ipsilateral pons and other brain regions response to pain such as basal nuclei,thalamus,cingulated gyms and prefrontal cortex was detected during the acute spontaneous attack as compared with during headache remission(P<0.05,corrected by Monte Carlo simulation). 2 Positive functional connectivity was detected between ipsilateral pons and other brain regions related to pain within pain state and within non-pain state (P<0.05,corrected by false discovery rate,FDR).Increased functional correlation between ipsilateral pons and other pain-related brain regions such as ipsilateral prefrontal cortex and contralateral subcallosal gyrus was detected during the acute spontaneous attack as compared with during headache remission(P<0.05,corrected by Monte Carlo simulation).

结果1。对照组未发现CSD;同侧TNC放电频率,CSD中>CSD后>CSD前P<0.05对侧TNC放电频率,CSD前、中、后无统计学差异(P>0.05氟桂利嗪组同侧TNC放电频率,CSD前>CSD中(P<0.05),CSD前与CSD后及CSD中与CSD后之间无统计学差异(P>0.05)。2.1关于放免测定,各组血浆CGRP、SP水平有统计学差异(P<0.05),CSD组高于对照组(P<0.05),CSD组与氟桂利嗪组、对照组与氟桂利嗪组之间均无统计学差异P>0.05各组之间同侧三叉神经节中CGRP、SP水平未见变化(P>0.05.2关于免疫组化研究,右侧三叉神经节CGRP、SP免疫阳性细胞数三组之间有统计学差异(P<0.05),多重两两比较结果CSD组大于对照组(P<0.05),CSD组与氟桂利嗪组之间、对照组与氟桂利嗪组之间无统计学差异P>0.05左侧三叉神经节CGRP、SP免疫阳性细胞数三组之间无统计学差异(P>0.05CSD组中右侧三叉神经节CGRP、SP免疫反应阳性细胞数大于左侧(P<0.05)。3.1局部一致性分析发现两组患者头痛疼痛状态较非疼痛状态脑活动发生变化的脑区有同侧脑桥以及其他疼痛相关脑区如基底节区、丘脑、扣带回、前额叶皮层等(P<0.05,蒙特卡罗模拟校正)。2功能连接分析发现疼痛状态与非疼痛状态下主要疼痛相关脑区均与同侧脑桥有功能联系P<0.05,false discovery rate,FDR校正疼痛状态与非疼痛状态比较,同侧前额叶皮层、对侧胼胝下回等疼痛相关脑区与同侧脑桥之间功能联系增强(P<0.05,蒙特卡罗模拟校正。

Fig 1 At the experimental side, two weeks after operation (HE ×100) Many pieces of cartilage cells and spindle-shaped mesenchymal cells were found, by light microscope Fig 2 At the experimental side, twelve weeks after operation (HE ×100) Medullary cavity had formed, which contained hemoblasts and adipocytes, but the trabculae was not typical, by light microscope Fig 3 At the experimental side, twenty-four weeks after operation (HE ×100) The typical cancellous bone had formed, by light microscope Fig 4 At the control side, twenty-four weeks after operation (HE ×100) A large part of CXB was degraded, resorbed and replaced by fibrous tissue, but there was'not any new formed bone, by light mocroscope

图1 实验侧术后2周(HE ×100)镜下可见很多软骨细胞条索和团块生成及大量梭形间充质细胞图2 实验侧术后12周(HE ×100)镜下可见有髓腔形成,内含有造血和脂肪细胞,骨小梁尚不典型图3 实验侧术后24周(HE ×100)镜下可见形成典型的松质骨结构图4 对照侧术后24周(HE ×100)镜下可见大部分CXB被降解吸收,为纤维组织替代,无新骨形成

Basing on the setup of animal model of root avulsion of the brachial plexus, we divided the experimental animal into four groups by the operative method: Group A: one end of the maternal nerve graft was connected with the upper trunk of the healthy side by end-to-side neurorrhaphy, and the other end was sutured to the distal stump of musculocutaneous nerve infraclevicularly by end-to-end neurorrhaphy. Goup B: on the healthy side, the operation was the same, the other end was sutured to the distal end of C〓 by end-to-end neurorrhaphy on the affected side. Group C: the maternal nerve graft bridged the phrenic nerve and infraclevicular musculocutaneous nerve of the affected side by end-to-end neurorrhaphy. Group D: the phrenic nerve was sutured to the distal end of C〓 supraclevicularly by end-to-end neurorrhaphy.

在构建了模拟小儿臂丛神经根性撕脱伤的动物模型基础上,将实验动物按手术方式分组如下,A组:母鼠提供的的神经移植体一端与子鼠健侧臂丛上干行端侧吻合,另一端与患侧已切断的锁骨下肌皮神经远端行端端吻合。B组:母鼠提供的的神经移植体一端与子鼠健侧臂丛上干行端侧吻合,另一端与患侧已切断的锁骨上颈〓远端行端端吻合。C组:母鼠提供的的神经移植体桥接于子鼠患侧膈神经与锁骨下肌皮神经之间。D组:子鼠患侧膈神经直接与锁骨上颈〓远端行端端吻合。

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