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To evaluate the effect of cold stress on hypothalamic-pituitary-adrenal HPA axis in chic-kens,15-day-old male Isa chickens were subjected to acute(for 15min,1h,3h,6h,12h and 24h,respectively) and chronic(for 5d,10d and 20d,respectively) cold stress at 12℃±1℃.The level of expression of corticotropin releasing hormone mRNA in hypothalami and the contents of adrenocorticotrophic hormone,aldosterone and cortisol in serum of the chickens were detected.

为探明冷应激对雏鸡下丘脑-垂体-肾上腺皮质轴的影响,对15日龄公雏鸡进行了急性(15min、1h、3h、6h、12h和24h)与慢性(5d、10d和20d)冷应激处理(12℃±1℃),检测了雏鸡下丘脑促肾上腺皮质激素释放激素mRNA的表达水平及血清促肾上腺皮质激素、醛固酮及皮质醇的含量。

Results:Regulating the body temperature in dual-direction,Fr.A could antagonize the decrease of HSP contents of hypothalamus in hypothermal rats induced by aminopyrine, and abate the HSP content in febrile rats induced by yeast.

结果:Fr.A在双向调节体温的同时,可明显拮抗安痛定性低体温大鼠下丘脑HSP70含量的降低,对酵母性高体温大鼠下丘脑HSP70含量具有一定的降低作用。

The msg i perceived is relayed from the sensory cortes of the brain to hypothalamus which sent a msg to my adrenal glands.

这个消息从我的感应器官传到下丘脑(不是很清楚是不是这样叫的),然后下丘脑把信息传给肾上腺。

Methods: the animal model was produced by means of putting special moulds on the male rats being bred in cages separately. Using CHAIHUSHUGAN POWDER as trial drug to smooth the circulation of liver-Qi, the targets such as oltaction-licking latency % intromission latency, intromission frequency, ejaculation latency,ejaculation frequency, post-ejaculation interval had been observed. Fluorospectrophotometry had been used to measure the content of 5-HT in respective specimen which had been produced by separating plasm, fluid of broken platelets from rats venous blood and homogenating the hypothalami.

通过带模具单笼饲养法造模,以柴胡疏肝散作为疏肝理气试验用药,观察大鼠的嗅舔潜伏期、插入潜伏期、插入次数、射精潜伏期、射精次数、射精后不应期;取大鼠静脉血和下丘脑,制备血浆、血小板破碎液和下丘脑匀浆,运用荧光分光光度法检测各标本5-HT的含量。

In order to investigate the effect of IFN-γon the expression of TNF-αin the hypothala- mus-pituitary-ovary axisof RU486-induced aborted SD rats, RU486 was used to establish the abortion model, then the aborted rats were administrated with different doses of IFN-γintraperitoneal injection, the method of immunohistochemical ultrasensitive SP was us- ed to study the variation of positive TNF-αcells in hypothalamus, pituitary, ovary and uterus in normal pregnant group A, aborted model group B and three different doses of IFN-γgroup C,D,E. The main goal of this research was to study whether the low dose of IFN-γcould have a protective function to pregnancy and the mechanism of its function so as to provide morph- ologic basis for the scientific using of IFN-γin the process of animal abortion control.

为探讨IFN-γ对流产大鼠下丘脑-垂体-卵巢轴(hypothalamus-pituitary- ovary-axis,HPOA )TNF-α表达的影响,本试验用米非司酮(RU486)建立SD大鼠流产模型,通过腹腔注射不同剂量IFN-γ,采用超敏感免疫组织化学SP法(链霉素抗生物素—过氧化物酶法),观察了孕13天(d13)SD大鼠正常妊娠A组、流产模型B组、不同剂量IFN-γC、D、E组下丘脑、垂体、卵巢、子宫TNF-α的表达变化,探讨低剂量IFN-γ对妊娠是否有保护作用及其作用机制,期望能为在妊娠过程中如何科学应用IFN-γ防止动物流产提供形态学依据。

After injection of FG into the NTS, FG retrogradely labeled neurons were present bilaterally with a strong ipsilateral predominance in the hypothalamic regions, such as medial and lateral parvicellular portion of the paraventricular nucleus, posterior

将FG注入孤束核后,在下丘脑室旁核小细胞部、穹窿周区、下丘脑后区及弓状核等核团内都观察到数量较多的FG逆行标记神经元;EM1和EM2阳性神经元的胞体主要位于下丘脑背内侧核、腹内侧核

The down-regulation of hypothalamus CaMmRNA level is one of therapeutical mechanism that kidney tonify herbs Yougui Yin adjust symptom of kidney yang deficiency.

下丘脑中CaMmRNA水平升高与肾阳虚证有关,下丘脑CaMmRNA水平的降低是补肾中药右归饮改善肾阳虚症状的作用机理之一。

Hypocretin neuronpeptide in hypothalamic nuclei and its receptor are involved in the regulation of the Hb on sleep-wakeness process.The Hb is innerved by the lateral hypothalamic area,the lateral preoptic area and the arcuate nucleus.

下丘脑Hypocretin神经肽及其受体参与Hb对睡眠-觉醒调节的作用,且Hb接受下丘脑内睡眠相关结构LHA、LPO、ARC的纤维投射。

Results: Compared with the C group, the contents of CORT in blood and ACTH in pituitary gland are increased at the different time points. Compared with the C group ,the contents of CR11 in Hypothalamus are enhanced in S and SAI groups on list but those are reduced in S and SM groups on 16st and 21st. Compared with the S group ,the contents of CORT in blood and ACH in pituitary gland are increased in SM group on 11 at. Compared with the SM groups, the contents of CORT in blood are reduced in TKXLD groups on 11st, l6st and 21st. Compared with the SAT group respectively, the contents of CRH in Hypothalamus are decreased in TKXLD group on list and those in TKXLD group are increased on 16st and 21st.

结果:实验第11、16和21天悬吊组和悬吊加辐射组大鼠血清CORT和垂体ACTH含量高于正常组;悬吊组和悬吊加辐射组大鼠下丘脑CRH含量在实验第11天高于正常组,在实验第16天和21天低于正常组;实验第11天悬吊加辐射组大鼠血清中CORT的含量高于悬吊组;实验第11、16和21天,中药组大鼠血清CORT含量低于悬吊加辐射组,垂体ACTH含量低于悬吊加辐射组;中药组大鼠下丘脑CRH含量在实验第11天低于悬吊加辐射组,在实验第16天和21天高于悬吊加辐射组。

In order to explore effects of the traditional Chinese medicine for tonifying the kidney on hypothalamic-pituitary-gonadalaxis in trainee,two experimental investigations of training with taking the Chinese tonic medicine was performed,which were the endocrine function test in ordinary men and the exercise capability test in dashers.

补肾药对训练者下丘脑-垂体-性腺轴功能及运动能力的影响国家体委运动医学研究所谢敏豪,方子龙,万劲,邓静,高峡,杨天乐,杨则宜北京体育大学冯炜权提要对男性普通人和短跑运动员进行训练结合使用补肾中药&仙灵口服液&的观察表明,补肾阳法可防止运动性下丘脑

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