下丘脑的

The results showed that LRK could significantly inhibit the mammary hyperplasia caused by estrin, reduce the content of serum 〓, raise P level, promote the production of DA in hypothalamus and mammary tissue, decrease the release of 5-HT, inhibit the secretion of serum PRL, reduce the sensitivity of mammary tissue to estrin and progestogen, prevent the expression of mammary tissue on PCNA, the effect was equal to triphenylamine oxide, obviously superior to the control group of Ru Zeng Ning.

通过实验研究，建立了具有肾虚肝郁证侯群的乳腺增生病理模型，利用免疫组化技术、图像分析系统、荧光分光光度法、放射免疫法等现代医学研究方法，从病理形态学、医用体视学、神经内分泌学、阴道细胞学等方面，观察了利乳康口服液对模型动物整体状态、乳腺组织病理形态、血清激素、神经递质以及卵巢功能的影响，结果表明利乳康口服液能明显抑制雌激素引起的乳腺组织增生，降低血清E〓含量，升高P水平，促进下丘脑及乳腺组织中DA的产生，减少5-HT释放，抑制血清PRL分泌，降低乳腺组织对雌、孕激素的敏感性，阻止乳腺组织PCNA的表达，其效应与三苯氧胺相当，明显优于乳增宁对照组；另外，利乳康口服液还能缓解模型动物肾虚肝郁证侯群，增加其体重，调节其整体状况，改善模型动物不规则动情周期，减轻其子宫及卵巢的病变，抑制子宫内膜的过度增长，调节卵巢功能，揭示了中药利乳康口服液对神经内分泌和卵巢功能的整体调控作用，以及对本病发生、发展的预防作用

RESULTS:After pinealectomized mice was irradiated WBI with 75 mGy X-rays,we found levels of plasma corticosterone increased obviously,and the effects of the proliferative reaction of splenocytes to ConA and spontaneous proliferation of thymocytes was found to be decrease. But injecting melatonin into pinealectomized mice or putting melatonin in the cultured cell,its immune functions might renew the enhancement.CONCLUSION:Melatonin of pineal gland might regulate the immunoenhancement induced by low dose radiation.MeSH Pineal body; Melatonin; Radiation; Corticosterone; Immunity,cellular

低剂量辐射(low dose radiation，LDR)全身照射(whole body irradiation，WBI)可引起免疫系统的兴奋效应，主要表现在以T淋巴细胞功能激活为主的细胞免疫和体液免疫功能的增强并可提高机体的抗瘤作用［4，5］，在LDR诱发免疫功能增强的同时伴有下丘脑-垂体-肾上腺皮质系统功能下调等神经内分泌功能的改变，神经内分泌对免疫系统的调节可能是LDR免疫兴奋效应发生的必要条件，松果腺MLT与辐射免疫兴奋效应的关系值得研究。

The results showed: 1 All GH deficient children presenting with polyuria and polydipsia had severe ADH deficiency; 2 In 11 GH deficient children without polyuria and polydipsia, 7 were found endogenous ADH insufficient; 3 The children with sho...

结果表明：(1)GH缺乏、伴多饮多尿症状的生长落后儿童均为ADH严重缺乏；(2)GH缺乏、无多次多尿症状的生长落后儿童11例中7例为潜在性ADH缺乏；(3)GH正常、伴多饮多尿症状的生长落后儿童都为ADH部分缺乏；(4)GH正常、无多饮多尿症状的生长落后儿童的下丘脑-垂体后叶功能基本正常。

The classify and function of nerve fibers; Sensory specific projection system and nonspecific projection system; Cortical motor area and cortical sensory area; Thalamus nucleus; Muscle tonus and attitude regulation by brain stem; Functions of cerebellum; Visceral motor regulation by hypothalamus; Wakefulness and sleep; Conditioned reflex, Mechanism of learning and memory.

神经纤维的分类及功能；感觉的特异与非特异投射系统；大脑皮层运动代表区和感觉代表区；丘脑核团；脑干对肌紧张和姿势的调节；小脑的功能；下丘脑对内脏活动的调节；觉醒与睡眠；条件反射，学习和记忆的机制。

Moreover, we established the model of apoptosis induced by corticosterone and explored the effect of gangliosides, which is a active component in pilous antler, on this apoptotic cell model. The effects of gangliosides on neurotransmitter release, neuronal filopodia formation, calcium signal cascade and 5-HTl A receptor-ligand competitive binding were also studied. 2. Theory study: The viewpoint on brain and kidney in traditional Chinese medicine and that in Western medicine were comparatively studied. The essence of the relationship between kidney and brain in traditional Chinese medicine Subsequently, in combination with the analysis on the results in the empirical study, we discussed the essence of the relationship between kidney and brain in traditional Chinese medicine from the viewpoint about the feedback mechanism of hippocampus-hypothalamic-pituitary-adrenal.

体外实验采用糖皮质激素建立神经细胞凋亡模型，研究鹿茸有效成分的干预作用，并从神经递质释放、神经细胞丝状伪足生成、神经细胞钙信号途径、5-HT_(1A)受体配体竞争结合等方面进行机制探讨。2、理论研究：比较中西医学对肾和脑的传统认识以及现代研究，分析中医学中肾和脑的现代科学内涵，结合实验研究结果，从现代生物学海马—下丘脑—垂体—肾上腺轴负反馈机制的角度对中医肾脑相关理论的实质进行探讨。

On the base of research, a new academic opinion was put forward firstly in-out country: as for series changes caused by psychiatry, the liver in TCM is the regulating core,"Live bears the dipersive effect" not only can unitarily regulate the HPAA, but also hold the material central neuro mechanism, which show the organic unification of part (central material brain machanism) and uitary.

在国内外首次提出新的学术观点：&对于情志因素引起的各种变化，肝是机体调节心理应激反应的核心；中医肝主疏泄调畅情志的功能在实现对下丘脑-垂体-肾上腺皮质系统的整体性调节上，还存在着一定的具体的中枢神经机制；在作用机理上体现出局部与整体的有机统一&。

Gangliosides antagonized the apoptosis induced by corticosteron, and the underlying mechanism is related to activiation of neuronal calcium signal cascade, promoting neurotransmitter release. Gangliosides also have an ability to promote the neuronal filopodia formation and may have a antidepressive-like neuroprotecive effect. 2. Theory study: We explained the clinical symptoms showed in the syndromes of deficiency of kidney-Yang and deficiency of kidney-Yin with modern scientific technical terms. Moreover, we supposed the location of kidney of traditional Chinese medicine may be in the hippocampus but not in the hypothalamus, which is also the centre of learning and memory.

鹿茸有效成分能够拮抗皮质酮诱导的神经细胞凋亡，其机制与影响钙信号途径、促进神经递质释放有关，鹿茸有效成分还能促进神经细胞丝状伪足生长，并且可能具有抗抑郁药样的神经保护作用。2、理论研究：用现代科学语言对肾阳虚证和肾阴虚证临床症状的病理生理机制进行合理的解释，提出中医肾脑相关理论实质假说，推测补肾中药的调控点应当在下丘脑—垂体—肾上腺轴的高级中枢海马，而非下丘脑。

Methods: The study was designed to observe SS and influence of serum CD_4~+、CD_8~+、IL-2、IL-6、TNF-α, splenic lymphocyte transformation rate, the expression of SS、SSTR-2 in spinal cord、PAG、NRM and hypothalamus the coexistence of SS and enkephalinergic neuron in back corner of spinal cord, the coexistence of SS and 5-HT neuron in NRM by using methods of behavioral nociceptive threshold test, measure of foot's cubage, flowcytometry, MTT, radioimmunity, HPLC-ECD, immunohistochemistry, laser confocal microscope on FAC-induced hyperalgesia.

以弗氏完全佐剂诱发的炎症痛模型大鼠为研究对象，应用行为学痛阈观察、足跖容积测定、流式细胞检测法、MTT法、放射免疫法、高效液相电化学法、免疫组织化学技术法、激光共聚焦技术等方法，观察SS和电针对痛阈、大鼠CD_4~+、CD_8~+、IL-2、IL-6、TNF-α水平和脾淋巴细胞转化率等指标的影响，以及SS、SSTR-2在脊髓和PAG、NRM及下丘脑部位的表达、在脊髓SS与脑啡肽能神经元的共存现象及在NRM中与5-HT能神经元的共存情况。

Adult patients with structural hypothalamic damage show impaired satiety, but the changes observed in circulating ghrelin and PYY concentrations in response to a test meal do not indicate a central role for these gut hormones in the control of appetite and the pathogenesis of obesity in these patients.

下丘脑结构性受损的成年患者过饱感觉功能障碍，但是餐后血液中的Ghrelin和PYY的水平的变化没有提示这些肠道激素在食欲的控制和肥胖的发病机制中发挥作用。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐