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It is believed that the dysfunctions of monoamine nerve in central nervous system and HPA axis are responsible for depression.

目前认为,中枢单胺神经和下丘脑-垂体-肾上腺轴功能异常可能是抑郁症发病的主要生物学原因,以此理论支持的抗抑郁药物虽有较好的疗效,但仍然对近30%的抑郁症患者无效。

Puzzlingly, such effect is transient and depression is usually reinstated after the first episode of recovery sleep, or even after short naps .

睡眠剥夺可能通过改变5-羟色胺(serotonin 5-HT)系统起作用,5-HT_(1A)受体作为突触前的自身受体在调节中缝核5-HT神经元的活性中发挥着关键作用,并且作为突触后受体介导5-HT对边缘系统、皮层、下丘脑及其它一些脑区部位的作用,使得5-HT_(1A)受体的调节对于精神疾病非常重要。

Autoimmunity hypothesis of schizophrenia figures schizophrene has a certain degree of immunological functional disturbance,Hypothalmu- pituitary- adrenal axis can produceimmunosuppression. Hydrocortisone,the production of HPA axis,serve as important medium of immunosuppression, so we presume that hydrocortisone possibly induce immunological dysfunction of schizophrene.

精神分裂症的自身免疫假说认为精神分裂症患者存在一定程度的免疫功能低下,而下丘脑-垂体-肾上腺轴功能紊乱被认为是引起免疫抑制作用的主要机制之一,其中皮质醇是免疫抑制作用的重要介质,因此我们推测精神分裂症患者可能存在有皮质醇含量增高有关。

The inhibitory efFect of deep somatic nerve stimulation on the HVEs does not depend upon the buffer nerves, but is related to the function of medial medulla oblongata.

上述结果表明:化学感受性反射能易化刺激下丘脑诱发的室性期前收缩,而压力感受性反射可以抑制这种室性期前收缩,但躯体传入冲动对这种心律失常的抑制作用并不依赖于缓冲神经的存在,而有赖于延做中线核群的完整性。

Purpose: To investigate the effect of acupuncture combined with processing herb for the reproductive endocrine of postmenopausal osteoporosis and bone metabolism levels, and research the functional mechanism of the effect from the angle of hypothalamic- pituitary- ovarian axis、suprarenal axis and thyroid axis.

目的:观察针刺结合小剂量淫羊藿,治疗绝经后骨质疏松症的临床疗效,及其对绝经后生殖内分泌、骨代谢水平的影响,从下丘脑-垂体-卵巢轴、肾上腺轴、甲状腺轴的角度探讨针药结合对绝经后骨质疏松症的作用环节。

Results After 4 weeks medication, the gain weight、LH in serum、growth of uterus and ovary be slower significantly. Kangzao-Ⅱ Decoction can reduce asteroidal colloid cell in hypothalamus and acidophil cell in pituitary which secrete FSH and LH.

结果 抗早2号方对青春期雌性SD大鼠的体重增长有抑制作用,能明显抑制血清LH水平,使大鼠的子宫腺体发育延迟,卵巢内卵泡发育滞后,能使青春期雌性SD大鼠的下丘脑星形胶质细胞数量减少,体积缩小,使脑垂体分泌促卵泡生成素和LH的嗜酸细胞减少。

In this study, real-time PCR technology was used to dectect the expression of PRL mRNA and its receptor in the reproductive tissues,which is hypothalamus-pituitary-ovary-oviduct four important tissues. The aim was to compare the difference of PRL mRNA expression in the different state of ovulatory, broody and after broody, and to analyse the relation between expression and reproduction.

本试验利用real-time PCR技术检测雪山草鸡下丘脑、垂体、卵巢、输卵管四个繁殖轴组织中PRL基因及其受体的表达量,以确定处在生产、抱窝、醒抱三个不同状态母鸡PRL基因表达的差异,并分析基因表达量的差异与生产性能的相关性。

The PRL-like cells were also presented in the ventral ependyma of the lateral ventricle and the glial lamina in the basal surface of the brain. The processes of PRL-LIR cells in PPN, SCN, PVN and PAN mainly projected to the third ventricle, those in AN and ELV mainly projected to the lateral ventricle, and those in SON to the glial lamina in the basal surface of the brain. The results showed that PRL could be released into ventricularis system and participate in the regulation of the cerebrum-cerebrospinal fluid circuit.

视前室旁核、视交叉上核、下丘脑室旁核、弓状核等核团内的PRL阳性神经元有突起向第三脑室投射,伏隔核内及侧脑室室管膜上的PRL阳性神经元有突起伸至侧脑室,视上核的PRL阳性神经元也有突起投射至脑基底神经胶质板,表明鸡脑内的PRL可以释放入脑室系统,参与调节脑-脑脊液神经体液回路。

Glucocorticoid is a kind of steroid compound synthesized and secreted by adrenal cortex fascicular zone, which is a key factor of the hypothalamus-hypophysis-adrenal gland-immune axis.

糖皮质激素(glucocorticoid,GC)是下丘脑-垂体-肾上腺轴的关键分子,除具有重要的生理作用外,还具有很强的免疫抑制作用,临床上被广泛用于自身免疫性疾病的治疗。

It may means that Iridoids composition of Valeriana jatamansi Jones doesn\'t regulate the TPH1 transcription expression.3.4 Effection of Iridoids composition of Valeriana jatamansi Jones on SP and VIP of IBS rats induced by chronic stressMethods:Animals were randomly divided into7 groups:normal group,model group, OSD group,FXT group and Iridoids composition of Valeriana jatamansi Jones groups in quantiy of 24.92mg/kg,12.46mg/kg,6.23mg/kg.

造模后,中枢5-HT呈现降低趋势,这可能是导致动物出现活动能力下降和兴趣缺失的原因之一,蜘蛛香环烯醚萜可以增加下丘脑、海马和杏仁核中5-HT含量,推断蜘蛛香环烯醚萜可通过干预中枢的5-HT通路来改善IBS精神症状。3.2蜘蛛香环烯醚萜对胃肠激素的影响目的:探讨蜘蛛香环烯醚萜对慢性应激所致IBS大鼠SP和VIP的影响方法:动物随机分为对照组、模型组、昂丹司琼组、氟西汀组、蜘蛛香环烯醚萜24.92mg/kg、12.46mg/kg、6.23mg/kg组。

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