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The mechanisms of apoptosis of skin squamous cell carcinoma induced by IFN-γand ATRA Introduction and objective Skin squamous cell carcinoma is a malignant neoplasm derived from epidermal keratinocyte and squamous cells of skin appendant organ .It is one of the most common skin carcinoma, and the incidence rate of SCC is 20% in malignant non-melanoma. It is a common disease that seriously harms health of people in our country, so we should pay more attention to it.

维甲酸、γ-干扰素诱导皮肤鳞状细胞癌SCL-1细胞凋亡的机制研究前言与目的皮肤鳞状细胞癌(squamous cell carcinoma,SCC,简称鳞癌)是起源于表皮角质形成细胞或附属器鳞状上皮细胞的一种恶性肿瘤,是常见的皮肤恶性肿瘤之一,其发病率约占全部非黑素细胞癌的20%。

The mechanisms of apoptosis of skin squamous cell carcinoma induced by IFN-γand ATRA Introduction and objective Skin squamous cell carcinoma is a malignant neoplasm derived from epidermal keratinocyte and squamous cells of skin appendant organ .

维甲酸、γ-干扰素诱导皮肤鳞状细胞癌 SCL-1细胞凋亡的机制研究前言与目的皮肤鳞状细胞癌(squamous cell carcinoma,SCC,简称鳞癌)是起源于表皮角质形成细胞或附属器鳞状上皮细胞的一种恶性肿瘤,是常见的皮肤恶性肿瘤之一,其发病率约占全部非黑素细胞癌的20%。

We also have observed some organs pathological changes of juvenile Jian Carp, such as pancreas acinous gland and zymogen granules of acinous gland cell disappearing, intercellular substance hyperplasia and inflammatory cells soakage, hepatatrophia, liver cell granular or vacuolar degeneration and necrosis, karyolysis or pyknosis, glycogen granules decreasing, metanephros atrophy, metanephric canaliculus epithelium granular or vacuolar degeneration and necrosis, mitochondrion swelling and mitochondrion cristae disappearing, karyolysis, distal convolutal tubule microvilli desquamating, spleen marrow cell degeneration and necrosis, intercellular substance of spleen hyperplasia, spleen atresia, blood corpuscle disappearing.

后肾土黄色、淡褐色或苍白色,肾小管上皮细胞肿胀、颗粒或水泡变性、坏死,细胞内有大量血细胞流出,线粒体肿胀,嵴结构消失,细胞核溶解,肾间质甲状腺滤泡和拟淋巴细胞增生,远曲小管微绒毛脱落、管道细胞界限不清。心脏肌纤维肿胀、颗粒或空泡变性,严重的肌纤维溶解、变细或断裂,肌纤维间水肿、炎性细胞浸润,部分心肌细胞核浓缩。脾脏暗褐色,脾髓质细胞变性、坏死,拟淋巴细胞明显减少,淋巴细胞岛少见、岛中细胞成份减少,黑素巨噬细胞中心减少、体积缩小,脾脏网状基质水肿,脾窦闭锁,血细胞减少。

Results: the positive cells mostly included ependymal cells of myelocoele, glial cells, anterior horn motor neurons, and epithelial cells of spinal pia mater and their expressions were mainly located on cell membrane. interestingly, aqp4 distribution in glial cells and ependymal cells showed certain directivity, but the former was mainly in the membrane side contacting with capillary endothelial cells and the latter mostly in the basolateral membrane of ependymal cells.

结果: 免疫组织化学染色和原位杂交结果显示胶质细胞、前角运动神经元、中央管室管膜细胞、软脊膜上皮细胞均表达阳性,aqp4主要分布于细胞膜,其中,胶质细胞和中央管室管膜细胞表达存在极性,前者主要分布在与毛细血管内皮细胞接触的一侧,后者主要分布在中央管室管膜细胞的基底侧膜。

Cells of which DNA contents were more than 4C were 58.4%,which indicated the existence of proliferative vigorousness.

TM上皮细胞核面积及核周长介于正常上皮细胞与癌细胞之间,与后两者相比均有显著性差异(P<0.01),反映TM上皮细胞核有一定的异型性。

This paper reviews the pathways of ES cells in vitro being committed and differentiated to hematopoietic cells, cardiomyocytes, neural cells, adipocytes, pancreatic islets, endothelial cells, epithelia, osteoblasts, chondroblast and melanocytes.

文章综述了体外定向诱导ES细胞分化为造血细胞、心肌细胞、神经细胞、脂肪细胞、胰岛细胞、内皮细胞、上皮细胞、成骨细胞、软骨细胞和黑素细胞等的途径和方法。

Consistence to the PT-PCR result, TLR4 protein was strongly expressed at syncytotrophoblast of placenta, cytotrophoblast of chorion and epithelial cell of amnion of pregnancy complicated with syphilis by Immunohistochemistry.

TLR4在妊娠合并梅毒感染的胎盘合体滋养细胞、羊膜上皮细胞和胎膜中的平滑绒毛膜细胞滋养细胞上表达增强,与RT-PCR结果一致。

However, in 2 cases with intestinal tuberculosis, another chronic inflammatory disease of the large bowel, reticulum cells and countless neutrophilic leucocytes were seen in both cases , and plasma cells , atypical epithelial cells, and multinucleated giant cells in one case, In 7cases with amebic colitis countless neutrophilic leucocytes were seen in 2 cases (28.6%), plasma cells, reticulum cells, atypical epithelial cells, and multinucleated giant cells in one case (14.3%) respectively.

然而,在肠结核(另一种大肠慢性感染疾病)2例中,网状细胞和无数嗜中性白细胞在2例中均可见,浆细胞、网状细胞何多核巨噬细胞仅在1例中可见。在7例变形虫结肠炎中,2例无数嗜中性白细胞可见,浆细胞、网状细胞、不规则上皮细胞和多核巨噬细胞分别在1例中可见。

Under the regulation of different growth factors, they can differentiate into many kinds of cells, such as hepatocyte-like cells, cardiomyocyte-like cells, neuroglial cells, nerve cells, pancreatic islet-like cells and so on.

尽管如此,仍还不能将人羊膜上皮细胞称之为严格定义上的干细胞,因其不具有长期的自我更新和产生单个细胞克隆的能力,此外人羊膜细胞在体内分化成有功能的各种细胞类型需要进一步研究证实。

Since an excessive cell growth is considered as the main pathological event, cell proliferation model occupy most of the animal models, and these cells include retinal pigment epithelial cell, fibroblast cell, cartilage cell and vascular endothelial cell.

由于PVR的主要病理变化是细胞的过度增生,因而动物模型多以细胞增生模型为主,细胞种类有视网膜色素上皮细胞、成纤维细胞、软骨细胞、血管内皮细胞等。

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