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Cancer of the larynx and hypopharynx is one of the most common head and neck malignancy. Squamous cell carcinoma remains the most common pathologic type, accounting for more than 90% cases. Although therapeutic modality has improved gradually, there is no sign that the 5-year survival rate has improved during the past 20 years. The metastasis of tumor cells represents the primary source of clinical morbidity and mortality in the large majority of laryngeal and hypopharyngeal tumors.

中文摘要喉癌及下咽癌是常见的头颈部癌症之一,它的组织病理学诊断百分之九十以上为鳞状上皮细胞癌,虽然医学逐渐进步,但此疾病患者的存活率在最近20年内并没有增加的现象,对咽喉癌病患的治疗而言,是否出现淋巴结及远隔转移对预后具有决定性的影响。

SSTR2 may participate in the regulating cell apoptosis and may perform function in malignance.

卵巢癌组织细胞中SSTR2的表达可能参与细胞凋亡的调节机制,在卵巢上皮性肿瘤恶变的过程中发挥作用,并与恶性程度关系密切,有可能成为卵巢癌预后评估的参考指标。

In our study, we found menadione has anticancer potential on human breast adenocarcinoma MDA MB 231 by weather cell cycle arrest, anti proliferation, or apoptosis. Low concentration of menadione (5.8μM) significant inhibited growth curve on breast cancer cells (MDA MB 231) but not breast cells (MCF 10A) by performing MTT and trypan blue cell counting. RT-PCR and western blotting showed menadione increase p21 gene and protein expressions but decrease cyclin E and CDK2 protein expression resulting in cell cycle G0/G1 arrest by flow cytometry.

MTT及生长曲线的实验,发现menadione在低浓度且长时间作用情况下,对在於人类乳腺上皮细胞癌(MDA-MB 231)是有明显的抑制作用,而在正常乳腺细胞(MCF-10A)则没有影响,在分子转录上及蛋白质表现方面也发现低浓度menadione处理24时能使MDA-MB 231诱发p21基因及蛋白表现量增加及cyclin E、CDK2抑制,再经由流式细胞仪分析也发现低浓度 menadione 处理24小时能使MDA-MB 231细胞周期GO/G1比例上升,造成细胞周期停滞,进而抑制细胞生长。

It was found that the extract of Ficus carica leaves showed remarkable inhibitory and killing effects on the Newcastle disease virus.

采用组织细胞培养技术,充分利用无花果叶提取物中的有效成分,在人上皮样癌(Hep-2)细胞株、地鼠肾(BHK21)细胞株和鸡胚成纤维细胞上研究其抗新城疫病毒的作用。

This study is to investigate if the expression levels of mesothelin would correlate with chemotherapeutic response of patients with EOC.

这个研究的目的,在於评估上皮性卵巢癌组织中mesothelin表现的多寡,是否会和临床上病人对化学治疗的反应有所相关。

Most patients' death arise from the metastatic spread of primary tumors There is an urgent need for the finding of novel anti-tumor and anti–metastatic drugs to improve the quality of life and survival rate of patents Justicia procumbens is an herb and used to reduce fever inflammation and canker in Taiwan We've detected that 0 3 μM JA could effectively inhibit the proliferation of oral cancer cells OC-2 and HSC3 but not normal oral keratinocytes in MTS assay JA-treated OC2 underwent apoptosis as suggested by increased sub-G1 DNA contents condensed nuclear morphologh and DNA fragmentiation The migration activity of OC-2 was also significantly reduced by treatment with low concentration of JA The expression of ?

大部分的口腔癌病患死於原位癌的转移和扩散,寻找有效抗癌和抗转移的药物疗法来增进病患的生活品质和存活率,对治疗口腔癌而言非常重要。爵床草是台湾民间常用草药,常被用来消炎止热和治疗口疮、乳瘤。我们利用MTS分析,发现处以0 3 μM的JA 48小时,即可有效抑制口腔癌细胞OC-2和HSC3的增生,但不影响正常口腔上皮细胞生长。OC-2经JA处理后,其sub-G1的DNA含量增加,并可观察到DNA固缩和梯度断裂的现象,说明JA可使OC-2走向细胞凋亡。除此之外,0 3 μM的JA亦可有效降低OC-2的迁移能力。

Previous studies have shown that searching for a precancerous cervical lesion called cervical intraepithelial neoplasma using an HPV test is more sensitive but has more false-positives than conventional Pap smears, where doctors look for abnormal cells on a slide.

既往研究显示使用HPB检测癌前宫颈病变-上皮内新生物-方面更加敏感,但是假阳性比传统的Pap斑点法要高,医生使用该方法在切片上寻找异常细胞。

When characteristic findings as polypoid, intraluminal, and nonobstructive masses are present on image studies, some diagnosis such as spindle cell carcinoma, leiomyosarcoma and lymphoma should be considered first.

当在图象学上有特别的发现像是类瘜肉状,腔室内的,非阻塞性的肿块时,一些诊断像是梭状上皮细胞癌,横纹肌肉瘤,淋巴瘤都需作第一考虑。

Objective To test the expression of CD44 gene in colorectal polyps, cancers in contrast to that of normal mucosae, and investigate its importance in the progression and metastasis of colorectal tumors.

目的 检测大肠息肉、癌及相应正常大肠粘膜组织CD44基因mRNA表达,探讨该基因表达在大肠肿瘤进展转移中的意义以及癌组织上皮源性亚型与造血源性亚型比值的临床意义。

The researchers calculate that if moderate- or heavy-drinking ALDH2-deficient Japanese men reduced their consumption to under 16 drinks a week 53 percent of esophageal squamous cell cancers in that group could be prevented.

研究人员计算了一下适度或者大量饮酒且缺乏ALDH2的日本男人每周少喝16瓶酒的情况,发现这一组人中患上食道鳞状上皮细胞癌的风险减少了53%。

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