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Methods] A total RNA from 10 cases withovarian papillary serous cystadenocarcinoma and normal ovarian tissues were extracted by a single step method of gene chip. The cDNA retro?鄄transcribed from equal quantity mRNA derived from 10 cases with ovarian papillary serous cystadenocarcinoma and normal ovarian tissues. The cDNA strand was labeled with fluorescent Cy5 and Cy3(normal ovarian epithelial cells) as probes.

方法] 采用基因芯片技术,按一步法分别抽提10例卵巢浆液性乳头状囊腺癌患者的癌组织和正常卵巢组织的总RNA并纯化mRNA;逆转录合成以Cy5荧光标记卵巢癌细胞和Cy3荧光标记正常卵巢上皮细胞的cDNA作为探针,在含有8 464点人类体细胞基因模板的表达谱cDNA芯片上进行杂交。

Results:Verrucous carcinoma was classified into three groups for clinical characteristics, ectogenesis group,kystis group and infiltrating group. The carcinoma epithelium cell grew exsertum like dilatate nail. Nest of squamous cell carcinoma could be found at the former of the cancer infiltration.

结果:口腔疣状癌按临床特征可分为外生型、囊肿型、浸润型,组织学上有膨大的上皮钉突呈"推进式"生长,部分病例浸润前缘有小团鳞状细胞癌灶。

It was the first time that using 〓 cell line and normal immunity inbreed line BalB/c mice as objects to construct the subcutaneous transplanting ovarian cancer model. Histopathological experiment proved that the transplanting tumor was undifferentiated cancer. The ovarian tumor marker 〓 and the epithelial tumor marker 〓 were positive in the transplanting tumors. According to these proofs we thought we had already succeeded in constructing animal tumor model.

本实验首次采用卵巢癌〓细胞系,以正常免疫力的雌性近交系BalB/c小鼠为对象,建立了卵巢癌皮下移植瘤模型,经病理组织学检查证实移植瘤为低分化癌,经免疫组化检测证实移植瘤组织中卵巢肿瘤标志物〓和上皮性肿瘤标志物〓表达阳性,据此我们认为动物肿瘤模型建立成功。

Chronic cervicitis with cervical erosion: This is a common gynecological diseases, is the basis of chronic cervicitis, the Ministry of cervicovaginal was from cervical squamous intraepithelial endometrial tube to replace the single-layer columnar epithelium can be transformed into the cervix squamous cell carcinoma.

慢性子宫颈炎伴宫颈糜烂:这是妇科常见疾患,是在慢性宫颈炎基础上,宫颈阴道部的鳞状上皮被来自子宫颈管内膜的单层柱状上皮取代,可以转变为宫颈鳞状细胞癌。

The CA125 is an epitope on a large mucin glycoprotein molecule of greater than 1 million Daltons,normal expressed on the coelomic epithelium,including ovarian surface.By now,CA125 assay has been used for monitoring response to primary treatment,detecting clinically occult ovarian cancer at the time of recurrence,as well detecting primary disease in early stage.The CA125 level is abnormal in over 90%of advanced stage ovarian cancer,but it is not increased in about 50%of the patients with stageⅠdisease.

卵巢癌肿瘤标记物中最常用的是CA125,它是体腔上皮正常表达的一种抗原蛋白,晚期卵巢癌中,超过90%病例CA125升高,而在Ⅰ期卵巢癌中,大约有50%病例CA125正常,因此血清CA125敏感性和特异性不能满足筛查指标的要求。

The feature was different between dysplastic small hepatocytes with crowd and proliferative nodules of hepatocytes.

小肝细胞和胆管上皮细胞的不典型增生是肝细胞癌和胆管癌的癌前病变。

Methods:ATP- ase postive Langerhans cells in normal membrance epiderm, atypical hyperplasia, carcinoma in site, invasive carcinoma was investigated by electronic computer image analyzer.

采用电子计算机图像分析方法对30例人类舌癌标本中正常上皮、不典型增生、原位癌及浸润癌ATP酶阳性的Langerhans细胞进行了数量及形态定量研究。

Objective: To study the expression of CD44v6 protein in the dysplasia, carcinoma in situ, invasive squamocellular carcinoma and adenocarcinoma of cervix uteri, and the relationship between the expression and the prognosis.

目的:了解CD44v6在宫颈上皮不典型增生、宫颈原位癌、宫颈浸润鳞癌及腺癌中的表达及其与预后因素的关系。

August 21, 2008 — Specific skin-odor profiles can be used to identify basal-cell carcinoma, researchers reported at the American Chemical Society 236th National Meeting and Exposition. These findings may eventually translate into novel and effective methods of diagnosing not only basal-cell carcinoma, but also squamous-cell cancer and melanoma.

August 21, 2008 —研究者在美国化学会第236届年会与展览中指出,特定的皮肤味道档案可以作为辨识基底细胞癌的工具,这些发现最终可以变为基底细胞癌和鳞状上皮细胞癌、黑色素瘤之新的有效诊断方式。

Results: Bax immunoreactivity was detected in 44 out of 72 cases of cholangiocarcinoma and 8 out of 25 cases of normal control, in which bile ducts among lobules in normal parts aside of hepatocellular carcinoma tissues were observed.

结果:在72例CHC中,Bax阳性44例(61.1%);用于对照的25例肝细胞肝癌的癌旁肝组织汇管区胆管上皮Bax阳性8例(32%)。bax在CHC中的表达强于正常对照组(P<0.01),在其中53例高、中分化的CHC的表达强于在19例低分化CHC的表达(P<0.01),在肝内胆管癌与肝外胆管癌的表达无显著差异(P<0.05)。

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