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Skin suqamous cell carcinoma, a kind of skin tumor origined fromkeratinocyte or skin appendant organ suqmaous cell, is one of the most commonnon-melanoma skin cancers (about 20%).

咪喹莫特对人皮肤鳞状细胞癌SCL-1细胞株作用机制的研究前言皮肤鳞状细胞癌是起源于角质形成细胞或附属器鳞状上皮细胞的恶性肿瘤,是最常见的皮肤恶性肿瘤之一,其发病率约占全部非黑素性皮肤细胞癌的20%。

The mechanisms of apoptosis of skin squamous cell carcinoma induced by IFN-γand ATRA Introduction and objective Skin squamous cell carcinoma is a malignant neoplasm derived from epidermal keratinocyte and squamous cells of skin appendant organ .It is one of the most common skin carcinoma, and the incidence rate of SCC is 20% in malignant non-melanoma. It is a common disease that seriously harms health of people in our country, so we should pay more attention to it.

维甲酸、γ-干扰素诱导皮肤鳞状细胞癌SCL-1细胞凋亡的机制研究前言与目的皮肤鳞状细胞癌(squamous cell carcinoma,SCC,简称鳞癌)是起源于表皮角质形成细胞或附属器鳞状上皮细胞的一种恶性肿瘤,是常见的皮肤恶性肿瘤之一,其发病率约占全部非黑素细胞癌的20%。

The mechanisms of apoptosis of skin squamous cell carcinoma induced by IFN-γand ATRA Introduction and objective Skin squamous cell carcinoma is a malignant neoplasm derived from epidermal keratinocyte and squamous cells of skin appendant organ .

维甲酸、γ-干扰素诱导皮肤鳞状细胞癌 SCL-1细胞凋亡的机制研究前言与目的皮肤鳞状细胞癌(squamous cell carcinoma,SCC,简称鳞癌)是起源于表皮角质形成细胞或附属器鳞状上皮细胞的一种恶性肿瘤,是常见的皮肤恶性肿瘤之一,其发病率约占全部非黑素细胞癌的20%。

Results of the 621 patients, 388 were identified to have ASCUS, 147 had low-grade squamous intraepithelial lesions, 75 had high-grade squamous intraepithelial lesions and 11 had squamous cell carcinomas.

结果 将细胞学结果与组织学结果作对比分析,细胞学异常的621例样本中ASCUS 388例,低度鳞状上皮内瘤变147例,高度鳞状上皮内瘤变75例,鳞状上皮细胞癌11。

Microspectrophotometer was used to measure the DNA content of 3 mucosa specimens of normal blad- der, 5 papillomas and 15 bladder transitional cell carcinomas. The transitional cell carcinoma was divided into 3 gradesand each grade group comprised 5 cases.

应用显微分光光度计检测膀耽正常粘膜、膀胱乳头状瘤及膀胱移行细胞癌共23倒(正常粘膜3例、乳头状瘤5例及移行细胞癌15例,移行细胞癌分三级,Ⅰ级、Ⅱ级、Ⅲ各5例),其结果显示,正常粘膜上皮细胞和乳头状瘤细胞核及移行细胞癌细胞核Ⅰ、Ⅱ、Ⅲ各组之间胞核DNA含量均值有显著的差别(P.05~0.01)。

Clinical manifestations are soreness on epigastric region, decreased appetite, distention after meal and eructation. It belongs to "epigastric pain" and "Stomach Pi syndrome" in TCM with characteristics of repetition and pertinacity. In 1978, WHO listed chronic atrophic gastritis as precancerous lesions of gastric cancer because its complications of intestinal metaplasia and dysplasia are closely related to gastric cancer. This has been a research focus in clinical practice and pathology for years.

临床主要表现为上腹隐痛、食欲减退、食后饱胀、嗳气等,属中医学"胃脘痛"、"胃痞"等范畴,具有反覆发作、迁延难愈的特性。1978年WHO将慢性萎缩性胃炎列为胃癌的癌前状态,而在其基础上伴发的肠上皮化生(Intestinal metaplasia,IM)和域异型增生(DYSplasia, DYS),则与胃癌的发生关系密切,被视为癌前病变(Precacerous lesions Of gastric cancer, PLGC)多年来始终是临床及病理学研究的重点。

The expressions of E-cadherin and α-catenin in specimens of 54 breast carcinomas and 21 normal breast tissues around tumor were measured by immunohistochemical method. Results In normal breast tissues, E-cadherin and α-catenin were expressed on cell membrance of ductal and acinic cells. No abnormal expressions were found in normal breast tissues. The abnormal expression rates of E-cadherin and α-catenin in breast cancer were 51.9% and 63.0% respectively.

结果 21例癌旁正常组织中,上皮钙黏蛋白和α-连接素均主要定位于腺泡或导管上皮细胞膜上,显示了细胞-细胞间交界和细胞轮廓,二者均表达正常;54例乳腺癌组织中上皮钙黏蛋白和α-连接素的异常表达率分别为51.9%和63.0%。

To reveal chemokines mediating the celiac metastasis of epithelial ovarian carcinoma by way of investigating the chemokine receptor expressions in serous epithelial ovarian carcinoma cell lines and tissues, and the corresponding ligand expressions in membrana abdominis.

本研究通过分析浆液性上皮性卵巢癌细胞系和组织趋化因子受体的表达,及腹膜间皮细胞相应配体的表达,以揭示趋化因子介导上皮性卵巢癌腹腔内转移机制。

For comparison, 30 cases of epithelial ovarian tumors(10 cases of endometrioid adenocarcinoma, 12 cases of serous cacinoma, 5 cases of clear cell carcinoma, 3 cases of mucinous carcinoma) and 10 cases of renal clear cell carcinoma were also studied.

同时选择30例卵巢上皮性肿瘤(10例内膜样腺癌;12例浆液性腺癌;5例透明细胞癌及3例粘液性腺癌)和10例肾脏透明细胞癌作为对比研究。

Histologically, there were 2 cases of MC, 7 of MLMP (7 cases; 3 of them with intraepithelial carcinoma and 1 with microinvasion), and 9 of MCas (9 cases, 5 of them associated with MLMP and 1 associated with MC). Three of the MCas had areas of anaplastic or sarcomatoid carcinoma whereas 1 had an associated sarcoma.

组织学上,2例为MC、7例MLMP(其中伴上皮内癌3例,伴微浸润1例)、9例MCas(其中5例合并MLMP,1例合并MC)。9例MCas中有3例伴未分化癌或肉瘤样癌区域,而其中1例伴肉瘤。

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