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The purpose of this study is to compare the keratin profile in DMBA-induced squamous cell carcinoma with that in normal hamster cheek pouch epithelium.

摘要本篇是诱癌剂DMBA所引发仓鼠颊囊袋之鳞状上皮样癌与正常囊代表皮中之角质蛋白之比较研究。

METHODS: COX 2 and VEGF protein expressions were detected by immunohistochemical staining in 15 seborrheic keratosis, 15 Bowen s disease, 20 basal cell epithelioma, 20 squamous cell carcinoma and 5 normal skin tissues.

免疫组织化学法检测脂溢性角化病15例,皮肤原位癌15例,基底细胞上皮瘤20例,鳞癌20例及正常组织5例COX 2和VEGF的表达。

Methods : From July 2003 to November 2007, 21 cases of sarcoma and SC Cancerous ulcer patients were treated, among which 11 cases male and 10 cases female, the age 14~83 (average 50 years old) and upper limb 6 cases and lower limb 15 cases; The pathologic diagnosis is: SC 6 cases, synovial sarcoma 4 cases, malignant fibrohistiocytoma 3 cases, adipose sarcoma 2 cases, osteogenic sarcoma 2 cases, malignant melanoma 2 cases, sarcoma epithelioides 1 case, derma-eminence fibrosarcoma 1 case.

自2003年7月~2007年11月治疗21例肉瘤及鳞癌性溃疡患者,男性11例,女性10例,年龄14~83(平均50岁)。上肢6例,下肢15例;病理为:鳞癌6例,滑膜肉瘤4例,恶性纤维组织细胞瘤3例,脂肪肉瘤2例,骨肉瘤2例,恶性黑色素瘤2例,上皮样肉瘤1例,皮肤隆突性纤维肉瘤1例。

Cancer of the larynx and hypopharynx is one of the most common head and neck malignancy. Squamous cell carcinoma remains the most common pathologic type, accounting for more than 90% cases. Although therapeutic modality has improved gradually, there is no sign that the 5-year survival rate has improved during the past 20 years. The metastasis of tumor cells represents the primary source of clinical morbidity and mortality in the large majority of laryngeal and hypopharyngeal tumors.

中文摘要喉癌及下咽癌是常见的头颈部癌症之一,它的组织病理学诊断百分之九十以上为鳞状上皮细胞癌,虽然医学逐渐进步,但此疾病患者的存活率在最近20年内并没有增加的现象,对咽喉癌病患的治疗而言,是否出现淋巴结及远隔转移对预后具有决定性的影响。

Objective To evaluate Chemical Luminal Immunoassay in detecting serum CA125 of patients with ovarian epithelial cancer.

卵巢癌是危及妇女生命的主要疾病之一,其中上皮性癌约占 5 0 %,对它的早期发现仍很困难。

SSTR2 may participate in the regulating cell apoptosis and may perform function in malignance.

卵巢癌组织细胞中SSTR2的表达可能参与细胞凋亡的调节机制,在卵巢上皮性肿瘤恶变的过程中发挥作用,并与恶性程度关系密切,有可能成为卵巢癌预后评估的参考指标。

The carcinogenic mechanism of nitrosamine is that it may cause the changes of tumor related gene and suppressor gene in esophageal epithelisl cells.

其致癌机制研究显示,亚硝胺可引起食管上皮细胞相关癌基因抑癌基因发生改变,大大促进癌变。

Objective: To investigate amplification of the human telomerase RNA component gene in the cervical exfoliated cells and to explore its value in diagnosis and treatment of cervical intraepithelial neoplasia and malignancy.

目的:研究宫颈脱落细胞中人端粒酶RNA组分基因的表达,探讨其在宫颈上皮内瘤变及鳞状上皮细胞癌诊断中的价值。

In gastric ulcerocancer, the main radiological changes of the interface are small teniform non-plicae area, the slim irregular plicae near the ulcer connecting with distal clubbed plicae. The juxta-ulcer presentation are instinct mucosal plicae, especially blurred teniform plicae and reticular plicae accompanying with "target sign" in most cases and the pathologic changes of peri-ulcer are chronic atrophic gastritis, intestinal epithelial metaplsia and epithelial heterotypic hyperplasia of gastric mucosal etc.

溃疡型胃癌溃疡病灶与周围交界面主要X线表现为小带状无皱襞区,近溃疡侧的纤细不规则皱襞与远侧的杵状皱襞相接;溃疡旁X线表现是粘膜皱襞影像多较模糊,尤以模糊条纹状皱襞及模糊网格状伴有&靶征&居多,病理镜下改变是以慢性萎缩性胃炎、肠上皮化生及胃粘膜上皮异型增生等癌前病变为主。

Methods The Fas, FasL and DR4, DR5, TRAIL were assessed in 45 normal cervices, 52 cervical intraepithelial neoplasia gradeⅢ and 51 cervical cancers by immunohistochemical method. The number of apoptotic cells was determined by morphological criteria and the number of proliferating cells by counting Ki-67-positive cells. Results Proliferation and apoptosis percentage was markedly increased with increasing severity of neoplasia.

应用免疫组织化学法检测45例正常宫颈组织、52例宫颈上皮内瘤变Ⅲ级(cervical interaepithelial neoplasia Ⅲ, CINⅢ)和51例宫颈鳞状上皮细胞癌组织中Fas、FasL、DR4、DR5、TRAIL的表达,并以显微镜定位表达位置,以Ki-67阳性细胞记数增生细胞数。

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