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Most patients' death arise from the metastatic spread of primary tumors There is an urgent need for the finding of novel anti-tumor and anti–metastatic drugs to improve the quality of life and survival rate of patents Justicia procumbens is an herb and used to reduce fever inflammation and canker in Taiwan We've detected that 0 3 μM JA could effectively inhibit the proliferation of oral cancer cells OC-2 and HSC3 but not normal oral keratinocytes in MTS assay JA-treated OC2 underwent apoptosis as suggested by increased sub-G1 DNA contents condensed nuclear morphologh and DNA fragmentiation The migration activity of OC-2 was also significantly reduced by treatment with low concentration of JA The expression of ?

大部分的口腔癌病患死於原位癌的转移和扩散,寻找有效抗癌和抗转移的药物疗法来增进病患的生活品质和存活率,对治疗口腔癌而言非常重要。爵床草是台湾民间常用草药,常被用来消炎止热和治疗口疮、乳瘤。我们利用MTS分析,发现处以0 3 μM的JA 48小时,即可有效抑制口腔癌细胞OC-2和HSC3的增生,但不影响正常口腔上皮细胞生长。OC-2经JA处理后,其sub-G1的DNA含量增加,并可观察到DNA固缩和梯度断裂的现象,说明JA可使OC-2走向细胞凋亡。除此之外,0 3 μM的JA亦可有效降低OC-2的迁移能力。

But our study suggested that the innervation of knee joint had two layer groups : the superficial layer group and the profunda layer group.

浅层为皮神经,部分干较粗,容易形成皮神经瘤;深层可以分为伸膝肌支膝关节支组成的髌上区组,隐神经分支组成的内侧及髌下区组,腓总神经关节支组成的后外侧区组,月国丛神经组成的月国区组4组。4组神经在关节囊外分布有重叠交叉,但区域明确。

Morphologically similar lesions from 26 patients (mean age, 62 y; range, 46 to 88 y; male/female ratio, 10/16) were retrieved from surgical pathology and consult files. Clinical and endoscopic data were obtained, and immunohistochemistry for S-100 protein, glial fibrillary acidic protein, neurofilament protein, epithelial membrane antigen, claudin-1, CD34, smooth muscle actin, and KIT was performed. The findings were compared with those in mucosal biopsies of 5 submucosal neurofibromas from NF1 patients.

我们从外科病理和档案库里调取了26例病变形态相似的病例(患者平均年龄62岁,范围:46至88岁,男女比例:10/16),得到了他们的临床及内窥镜资料,并给它们都做了S-100蛋白、胶质纤维酸性蛋白、神经丝蛋白、上皮膜抗原、闭合蛋白-1(claudin-1)、CD34、平滑肌肌动蛋白和KIT的免疫组化,所得的结果都与5例NF1患者粘膜下神经纤维瘤的粘膜活检的结果相比较。

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