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Results AQP1 is expressed at the apical and basolateral membrane of the microvascular endothelium; AQP3 was detected at basal cells of both the bronchiole epithelium and submucosal gland acinus; AQP4 is present in the basolateral membrane of columnar cells in bronchiole; while AQP5 is expressed in the apical membrane of type Ⅰ pneumocytes, and also at the apical of columnar cells of superficial epithelium and submucosal gland acinar cells.

结果本研究发现AQPs基因在羊肺中的表达分布与人相似,AQP1在肺内的毛细血管内皮细胞表达;AQP3在小支气管黏膜上皮的基底细胞的基侧膜表达,AQP4存在于小支气管黏膜上皮的柱状纤毛细胞的基侧膜;AQP5存在于Ⅰ型肺泡上皮细胞的顶质膜,存在于小支气管黏膜上皮柱状纤毛细胞,以及在气道黏膜下腺的腺细胞的顶质膜表达。

Skin suqamous cell carcinoma, a kind of skin tumor origined fromkeratinocyte or skin appendant organ suqmaous cell, is one of the most commonnon-melanoma skin cancers (about 20%).

咪喹莫特对人皮肤鳞状细胞癌SCL-1细胞株作用机制的研究前言皮肤鳞状细胞癌是起源于角质形成细胞或附属器鳞状上皮细胞的恶性肿瘤,是最常见的皮肤恶性肿瘤之一,其发病率约占全部非黑素性皮肤细胞癌的20%。

The mechanisms of apoptosis of skin squamous cell carcinoma induced by IFN-γand ATRA Introduction and objective Skin squamous cell carcinoma is a malignant neoplasm derived from epidermal keratinocyte and squamous cells of skin appendant organ .It is one of the most common skin carcinoma, and the incidence rate of SCC is 20% in malignant non-melanoma. It is a common disease that seriously harms health of people in our country, so we should pay more attention to it.

维甲酸、γ-干扰素诱导皮肤鳞状细胞癌SCL-1细胞凋亡的机制研究前言与目的皮肤鳞状细胞癌(squamous cell carcinoma,SCC,简称鳞癌)是起源于表皮角质形成细胞或附属器鳞状上皮细胞的一种恶性肿瘤,是常见的皮肤恶性肿瘤之一,其发病率约占全部非黑素细胞癌的20%。

The mechanisms of apoptosis of skin squamous cell carcinoma induced by IFN-γand ATRA Introduction and objective Skin squamous cell carcinoma is a malignant neoplasm derived from epidermal keratinocyte and squamous cells of skin appendant organ .

维甲酸、γ-干扰素诱导皮肤鳞状细胞癌 SCL-1细胞凋亡的机制研究前言与目的皮肤鳞状细胞癌(squamous cell carcinoma,SCC,简称鳞癌)是起源于表皮角质形成细胞或附属器鳞状上皮细胞的一种恶性肿瘤,是常见的皮肤恶性肿瘤之一,其发病率约占全部非黑素细胞癌的20%。

RESULTSThe average grade of squamous metaplasia and the average score of FL were significantly higher and the mean goblet cell density was significantly lower in diabetic patients than in control subjects.

结果]与正常对照组比较,糖尿病组患者角膜上皮损伤严重,杯状细胞密度显著降低,结膜上皮细胞的鳞状化级别显著增加,相比较均有显著性差异。

By in situ hybridization, 53BP2 mRNA expression is revealed in tumor cell nests of NPC paraffin sections. The strong positive particles localize in the nuclei of tumor cells; but slight positive signals are also found in tissue cells of chronic nasopharyngitis and connective tissue, such as lymphocytes and smooth muscle cells; There are also positive signals in the nuclei of hyperplastic squamous epithelial cells. However, 53BP1 mRNA expression is not found in nuclei of tumor cells, tissues of chronic nasopharyngitis and connective tissue.

原位杂交结果显示,石蜡切片的鼻咽癌癌巢内,可见53BP2的强阳性表达信号,信号呈紫色颗粒状分布于胞核,核仁清晰可见;而在相同条件下,在慢性鼻咽炎组织和癌旁上皮的结缔组织,也可见弱表达信号,如淋巴细胞和平滑肌细胞;在增生的鳞状上皮细胞的核内,可找到强阳性信号。53BP1在鼻咽癌、慢性鼻咽炎组织和癌旁上皮的结缔组织切片上,均无表达信号。

A portion of ductal cells and individual serous acinic cells of the minor salivary gland also expressed Fas not only in membranous but also in cytoplasmic pattern.

结果发现,在正常鼻咽粘膜表面及隐窝的假复层纤毛柱状上皮细胞胞膜、部分小涎腺的导管上皮和个别浆液性腺泡上皮细胞的胞膜和胞浆Fas阳性表达;鳞状化生上皮的表层细胞胞膜有Fas表达,但基底细胞未见Fas表达;浸润的淋巴细胞也不表达Fas.45.9%(17/37)的鼻咽非角化性癌Fas阳性,但只有不足10%的癌细胞胞膜微弱表达Fas。

Atypical polypoid adenomyoma is an uncommon polypoid lesion of the uterus that exhibits glandular and squamous epithelial cell proliferation with varying degrees of atypia, in association with a moderately cellular smooth-muscle stroma.

非典型性息肉状腺肌瘤是一种不常见的子宫的息肉状损害,表现为腺上皮和鳞状上皮细胞的增生,同时伴有不同程度的异型性,并与适度的细胞的平滑肌基质相关。

In small intestine, AKP activity was mainly distributed over four areas of epithelial cells: cytomembrane, cytoplasm, microvillus and the carbohydrate-riched cell coat. In liver, it was mainly located in canaliculi. In kidney, it mainly existed in such zones as brush border and memebrane of epithelial cells of proximal tubule, and cracks between kinds of tubules.

AKP活性在小肠主要分布在小肠绒毛上皮细胞的细胞膜、细胞浆、微绒毛和微绒毛表面的糖衣上,在肝主要分布在胆小管,在肾主要分布在皮质肾小管,尤以近曲小管的刷状缘、近曲小管上皮细胞膜和各种管状结构之间的腔隙内分布较多。

Three-dimensional Matrigel constructs contained aleolar forming units comprised of cells displaying AE2 cellular ultrastructure while expressing the SpC gene and gene product. The addition of tissue-specific growth factors induced formation of branching, sacculated epithelial structures reminiscent of the distal lung architecture.

通过对细胞亚微结构的观察和对SpC基因及其表达产物的分析,研究者发现培养体系中肺组织形成单位中具有能向肺泡II型上皮细胞分化的细胞;而通过添加组织特异性的生长因子,他们还发现这一做法会促进培养组织形成具有分支和囊状上皮结构的类似终末肺泡组织的形态结构。

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