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The fatter mice in Gewirtz's study had been bred to lack a protein known as toll-like receptor 5 (TLR5), which most intestinal cells sprout on their surface. Its job is to recognize and bind to the whiplike flagella that bacteria use to move around. TLR5 acts as a traffic cop for controlling the mass of pathogens living in the intestine; without it, the normally harmless gut bacteria tend to overflourish and expand in number. See and listen to an audio slideshow about obesity rehab.

Gewirtz 实验中的胖小鼠普遍缺乏一种被称之为 toll 样受体5 (TLR5)的蛋白,这种蛋白是肠上皮细胞表面分泌的, TLR5的作用是识别并结合在肠道细菌的运动器官鞭毛上,在对大多数肠道病原体的控制中, TLR5扮演着交通警察的角色,没有它,一般无害的肠道菌就会异常活跃并且大量繁殖。

Multiple familial trichoepithelioma is a benign skin tumor related to the pilosebaceous apparatus and inherited in autosomal dominant manner. Attentions have been focused on the mapping and mutation of the disease gene. But the clinical features of MFT are not clearly analyzed in Chinese.

多发性家族性毛发上皮瘤是一种皮肤附属器的良性肿瘤,是常染色体显性遗传性疾病,目前的研究集中在其致病基因的定位及突变上,但对该病的临床分析不够透彻。

Purpose: To report a case of Thygeson's superficial punctate keratitis with recurrence of punctate and pseudodendritic keratitis.

目的:报告Thygeson氏点状上皮角膜炎的病人临床上以复发性伪树突状角膜炎之表现以及治疗的经过。

Methods After removing epithelium,heart Dacron graft was covered to the anterior surface and was sutured to sclera at each quadrants,the superior and inferior recti muscle sutured to the center of Dacron.

去除角膜上皮,将心脏涤纶补片置于眼球前面,在 4个象限分别固定于巩膜表面,上、下直肌对端缝合固定于涤纶补片中央,再行全结膜瓣遮盖。

Histologically, there were 2 cases of MC, 7 of MLMP (7 cases; 3 of them with intraepithelial carcinoma and 1 with microinvasion), and 9 of MCas (9 cases, 5 of them associated with MLMP and 1 associated with MC). Three of the MCas had areas of anaplastic or sarcomatoid carcinoma whereas 1 had an associated sarcoma.

组织学上,2例为MC、7例MLMP(其中伴上皮内癌3例,伴微浸润1例)、9例MCas(其中5例合并MLMP,1例合并MC)。9例MCas中有3例伴未分化癌或肉瘤样癌区域,而其中1例伴肉瘤。

The secrection of the pyramidal secretory cells is ejected into the spermathecal cavity through secretory canals. The preliminary histochemical stainings shows that the secretion is a kind of glycoprotein and probably plays an important role in storing sperms.

上皮层由两种上皮细胞构成,其中锥形分泌细胞的分泌物经分泌管排入受精囊腔,组化染色初步表明其分泌物是一种糖蛋白,可能对精子的保存有重要作用。

Results The mortality rate of mice in 80 mg/kg, day cyclophosphamide group was 16.7%, and T level [ at 30th day :( 1.38 ± 0.31 );45th day:( 1.15 ± 0.26 ) ] and T/LH ratio [ at 30th day:(0.163 ± 0.014); 45th day:(0.127 ± 0.023 ) ] were significantly decreased (all P<0.05) at 30th day after induction;The concentration of MDA [at 15th day:(2.70 ± 0.41);30th day:(2.710.36);45th day:(2.67 ±0.43) ] was maintained at a high level (all P<0.05) during the 45 days ; Number of Leydig's cells [ at 15th day:(9.65 ± 0.75 ); 30th day:( 14.05 ± 0.67 ); 45th day:(8.49 ± 072)] and layers of spermatogenetic epithelia [ at 15th day:(4.75 ± 0.82);30th day:(3.60 ± 0.49);45th day:(3.74 ± 0.43 ) ] were significantly decreased ( all P < 0.01 ) and stabilized in a low level. The induced model was stable and the mortality rate was acceptable. In the 60 mg/kg, day cyelophosphamide group, the T level and T/LH ratio had no significant change (P > 0.05 ), and the concentration of MDA ,number of Leydig' s cell and layers of spermatogenetic epithelia recovered at 30th day after induction. The induced model was unstable.

结果 剂量每日为80 mg/kg体重小鼠成模后死亡率为16.7%,血清T[30 d:(1.38±0.31);45 d:(1.15±0.26)]及T/LH比值[30 d:(0.163±0.014);45 d:(0.127±0.023)]于诱导后第30天出现显著下降(P均<0.05),而诱导后睾丸组织内MDA含量[15 d:(2.70±0.41);30 d(2.71±0.36);45 d:(2.67±0.43)]维持高水平(P均<0.05),生精上皮层次[15 d:(4.75±0.82);30 d:(3.60±0.49);45 d:(3.74±0.43)]和间质细胞[15 d:(9.65±0.75);30 d:(14.05±0.67);45 d:(8.49±0.72)]均显著减少(P均<0.01)并稳定于低水平,模型稳定,死亡率适当;每日60mg/kg体重组小鼠血清T及T/LH比值于不同时段并未出现明显变化(P>0.05),且睾丸组织内MDA含量、生精上皮层次和间质细胞计数在30 d后有所恢复,模型不稳定;每日100 rag/ks体重组死亡率为30.0%,死亡率过高。

Results The pineal capsule was composed of a layer flattened epithelial cells and a subepithelial connective tissue.

结果 松果体囊由一层扁平上皮细胞和上皮下结缔组织构成。

RRV induced a significant increase in labeled cells in the portal tracts and in epithelial and subepithelial compartments of extrahepatic bile ducts, with onset within 3 days and peaks at 5-10 days.

RRV导致肝外胆管的肝门束、上皮上皮下间隔被标记细胞的显著增加,在3天内开始出现,5-10天达到高峰。

Taking all together, we proposed a energy metabolism model in gill epithelial cells during SW acclimation: The tricarboxylic acid cycle in MR cells is stimulated to produce enormous amount of energy for maintaining homeostasis and ion regulation at the 1st h after transfer to SW.

藉由上述结果,我们认为在鱼类适应不同盐度过程中,其鳃上皮细胞能量代谢的机制如下:当鱼类转移到海水后1st h时,其鳃上的MR cells会进入柠檬酸循环以产生大量的能量给MR cells。

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This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。

There is no differences of cell proliferation vitality between labeled and unlabeled NSCs.

双标记神经干细胞的增殖、分化活力与未标记神经干细胞相比无改变。